Vitamin K is not a single compound but a collection of fat-soluble vitamins that play critical roles in the human body. While most people are familiar with the general term, understanding its different names and forms is essential for comprehending its nutritional impact. This guide explores the different names for vitamin K, its major forms, and how they contribute to your overall health.
The Two Main Forms of Vitamin K
There are two naturally occurring forms of vitamin K, each with its own specific names and roles.
Vitamin K1: Phylloquinone
Found predominantly in green leafy vegetables, phylloquinone, or vitamin K1, is the primary source of dietary vitamin K for most people.
- Phylloquinone: This is the botanical name for vitamin K1, derived from its presence in plants, particularly within the chloroplasts involved in photosynthesis.
 - Phytonadione: This is a synthetic form of vitamin K1 often used in dietary supplements and medical treatments, such as for newborns to prevent bleeding.
 
Vitamin K2: Menaquinones
Menaquinones, or vitamin K2, are a family of compounds primarily produced by bacteria and found in fermented foods and some animal products. They are transported to extrahepatic tissues like bones and arteries, giving them a distinct function from vitamin K1.
- MK-4 to MK-13: Menaquinones have several subtypes, designated by the number of their isoprenoid side-chain units (e.g., MK-4, MK-7).
 - Menaquinone: This is the general name for vitamin K2 compounds. MK-4 is produced by the body from K1, while others like MK-7 are primarily from bacterial synthesis.
 
Menadione (Vitamin K3): The Synthetic and Toxic Form
In addition to the natural forms, menadione, sometimes called vitamin K3, is a synthetic precursor. However, due to its toxicity, it is no longer used in supplements or fortified foods for humans. It has been shown to cause liver toxicity and hemolytic anemia.
The Vital Functions of Vitamin K
Vitamin K's roles extend beyond its different names, proving crucial for several physiological processes.
Blood Coagulation
Vitamin K's most well-known function is its role in blood clotting.
- Acts as a cofactor for an enzyme that activates several clotting factors (II, VII, IX, and X) in the liver.
 - The name itself is derived from the German word for coagulation, Koagulationsvitamin.
 - Medications like warfarin work by inhibiting this process, requiring patients to carefully monitor their vitamin K intake.
 
Bone and Cardiovascular Health
Beyond clotting, vitamin K is essential for bone mineralization and cardiovascular health.
- Activates Proteins: It activates proteins like osteocalcin, which binds calcium to the bone matrix, and Matrix Gla Protein (MGP), which inhibits soft tissue calcification, including in the arteries.
 - Health Benefits: Some studies suggest that K2, in particular, may offer greater benefits for bone mineral density and arterial health, although more research is ongoing.
 
Comparison of Vitamin K1 vs. Vitamin K2
While both forms contribute to vitamin K activity, their origins, function, and bioavailability differ significantly.
| Feature | Vitamin K1 (Phylloquinone) | Vitamin K2 (Menaquinone) | 
|---|---|---|
| Primary Sources | Green leafy vegetables (kale, spinach), vegetable oils | Fermented foods (natto, some cheeses), animal products (egg yolk, meat) | 
| Produced By | Plants during photosynthesis | Gut bacteria and some animal sources | 
| Main Function | Primarily used by the liver for blood clotting factors | Transported to extrahepatic tissues, supporting bone and cardiovascular health | 
| Absorption/Retention | Poorly absorbed from plant sources; quickly cleared from the blood | May be better absorbed and stays in the body longer | 
| Subtypes | One main form (Phylloquinone) | Multiple subtypes (MK-4 to MK-13) | 
Food Sources for a Vitamin K-Rich Diet
Incorporating a variety of foods is the best way to ensure adequate intake of both vitamin K1 and K2.
Vitamin K1-rich foods:
- Spinach
 - Kale
 - Broccoli
 - Brussels sprouts
 - Cabbage
 - Soybean and canola oil
 
Vitamin K2-rich foods:
- Natto (fermented soybeans)
 - Hard and soft cheeses
 - Egg yolks
 - Chicken and beef liver
 
Conclusion
In conclusion, while there is no single another name for vitamin K, its true identity lies in its diverse forms: phylloquinone (K1) and menaquinones (K2). Understanding these different names is crucial for appreciating their distinct roles in blood clotting, bone health, and cardiovascular function. By consuming a balanced diet rich in green leafy vegetables, fermented foods, and certain animal products, you can ensure a consistent intake of both essential vitamin K forms. As always, consulting with a healthcare provider is recommended, especially for individuals on anticoagulant medications like warfarin, where dietary intake must be carefully managed to maintain the drug's effectiveness. For further reading on the science behind Vitamin K, explore reputable resources like the NIH Office of Dietary Supplements.