Skip to content

Magnesium Citrate or Magnesium Bisglycinate: Which is Better?

4 min read

With up to two-thirds of Westerners not meeting their magnesium needs through diet alone, supplements have become a popular way to fill the gap. However, choosing between popular forms like magnesium citrate and magnesium bisglycinate can be confusing, as each offers distinct benefits and effects on the body.

Quick Summary

This guide compares magnesium citrate and magnesium bisglycinate based on their bioavailability, absorption, specific benefits, and digestive impact. It clarifies their primary uses, whether for occasional constipation relief or for promoting relaxation, improved sleep, and overall health.

Key Points

  • Purpose is Key: Choose magnesium bisglycinate for relaxation, anxiety, and sleep, while reserving magnesium citrate for occasional constipation relief.

  • Bisglycinate is Gentler: Magnesium bisglycinate is less likely to cause digestive side effects like diarrhea, making it a better option for sensitive stomachs and long-term use.

  • Glycine's Calming Effect: The amino acid glycine attached to bisglycinate enhances its ability to calm the nervous system and promote restorative sleep.

  • Citrate Works Quickly: Magnesium citrate acts as a fast-acting osmotic laxative by drawing water into the intestines to soften stool.

  • Absorption Varies: Both are highly bioavailable, but bisglycinate's chelated structure ensures more consistent absorption for systemic benefits.

  • Combination Approach: Some individuals effectively use both forms: bisglycinate daily for relaxation and citrate for occasional digestive needs.

  • Seek Quality: Look for third-party tested supplements to ensure product purity and potency.

In This Article

Understanding Magnesium: A Vital Mineral

Magnesium is an essential mineral involved in over 300 enzymatic reactions in the body. It plays a crucial role in vital functions, including protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation. A deficiency can manifest in various symptoms, such as muscle cramps, fatigue, and sleep disturbances, leading many to seek supplementation. However, not all magnesium supplements are created equal, and the form of magnesium—the compound it's bound to—significantly impacts its bioavailability, absorption, and effects within the body.

The Difference Between Citrate and Bisglycinate

The core difference between magnesium citrate and magnesium bisglycinate lies in what magnesium is bonded to. Magnesium citrate is a compound where magnesium is combined with citric acid. Magnesium bisglycinate, also known as magnesium glycinate, is a chelated form where magnesium is bound to the amino acid glycine. This difference in chemical structure accounts for their distinct primary uses and effects on the digestive system.

Magnesium Citrate: The Digestive Aid

  • How it works: Magnesium citrate is known for its powerful osmotic effect. This means it draws water into the intestines, which softens the stool and stimulates bowel movements. This mechanism makes it particularly effective for addressing occasional constipation.
  • Absorption: This form is considered highly bioavailable, allowing the body to absorb it efficiently. However, this is largely overshadowed by its laxative properties, which can limit its use for long-term magnesium replenishment.
  • Considerations: While effective for digestive health, the laxative effect can cause discomfort, including cramping and gas, especially at higher doses. For consistent daily supplementation without bowel effects, it is often not the ideal choice.

Magnesium Bisglycinate: The Gentle, Calming Form

  • How it works: By chelating magnesium with glycine, the bisglycinate form offers superior cellular uptake without relying on the osmotic action in the gut. The amino acid glycine itself has calming properties that enhance the supplement's overall effect, making it ideal for relaxation and sleep support.
  • Absorption: The chelation process protects the mineral from being degraded by stomach acid, leading to a more consistent and highly bioavailable form of magnesium. This means a greater portion of the mineral is absorbed and utilized by the body, making it a better option for addressing chronic deficiency.
  • Considerations: Due to its gentle nature, it's a great choice for individuals with sensitive stomachs or those who experience digestive issues with other forms of magnesium. It is not a laxative and is better suited for long-term daily use for its systemic benefits.

Comparison Table

Feature Magnesium Bisglycinate Magnesium Citrate
Primary Use Promoting relaxation, sleep, and muscle recovery Occasional constipation relief
Bioavailability Excellent due to amino acid chelation Good, but often utilized for laxative effect
Digestive Impact Very gentle, minimal to no laxative effect Has a mild to strong laxative effect
Absorption Rate Highly efficient, superior cellular uptake Efficient, but may be hindered by laxative effect
Calming Effects Enhanced by the calming amino acid glycine Mildly calming, but not the primary benefit
Cost Typically more expensive per dose Generally less expensive per dose
Best For Individuals with sensitive stomachs, anxiety, and sleep issues People needing occasional digestive support

Making the Right Choice for Your Health Goals

The selection between magnesium citrate and magnesium bisglycinate ultimately depends on your specific health objectives. For those struggling with anxiety, stress, or sleep disturbances, bisglycinate is the superior choice due to its calming effects and high absorption without causing digestive distress. The added glycine provides synergistic benefits for relaxation and nervous system support. If your main concern is occasional constipation, magnesium citrate is highly effective as a short-term solution. However, its use for general supplementation is limited by its laxative properties, which can be inconvenient for daily intake.

For general health and long-term magnesium replenishment, bisglycinate's excellent bioavailability and gentle impact on the stomach make it a more reliable option. You might even consider taking both strategically: bisglycinate in the evening for relaxation and sleep, and a dose of citrate on an as-needed basis for digestive regularity.

Quality and Safety Considerations

Regardless of your choice, it is crucial to select high-quality supplements from reputable brands that use third-party testing for purity and potency. This ensures you are getting an effective product free from unnecessary fillers or contaminants. Always follow the dosage instructions on the label, or consult with a healthcare provider to determine the best form and amount for your individual needs, especially if you have pre-existing health conditions like kidney disease or are taking other medications.

Conclusion

While both are popular and bioavailable forms, magnesium citrate and magnesium bisglycinate serve fundamentally different purposes. The choice boils down to your primary health goal. Magnesium bisglycinate stands out for anyone seeking consistent, long-term support for relaxation, better sleep, and reduced muscle tension due to its superior absorption and gentle effects. Magnesium citrate, conversely, is the go-to for effective, short-term constipation relief. By understanding these key distinctions, you can confidently choose the magnesium supplement that is better suited to help you meet your wellness goals.

Visit the Office of Dietary Supplements at the National Institutes of Health for more information on the health benefits of magnesium.

Additional Considerations for Magnesium Supplementation

  • Dosage: Recommended daily intake varies by age and gender, but a common supplemental dose is around 200-400 mg. Always start with a lower dose to see how your body responds.
  • Dietary Sources: Increasing magnesium intake through foods like leafy greens, nuts, seeds, and legumes is always the best first step toward meeting your needs.
  • Consult a Professional: People with kidney disease, heart conditions, or those taking medication should always consult a healthcare provider before starting a magnesium supplement.

Frequently Asked Questions

Magnesium bisglycinate is bound to the amino acid glycine and is known for its calming effects and gentle impact on digestion. Magnesium citrate is bound to citric acid and is primarily known for its laxative effect, making it useful for constipation.

Magnesium bisglycinate is the better choice for improving sleep quality and reducing anxiety. The added glycine has calming properties that aid in relaxation, while the high bioavailability ensures your body can use it effectively without digestive upset.

Yes, many people take both strategically. For example, taking bisglycinate in the evening for relaxation and sleep, and using citrate on an as-needed basis for digestive support. However, always monitor your total daily magnesium intake.

Yes, magnesium citrate can cause loose stools or diarrhea, especially at higher doses, due to its osmotic laxative properties. This is why it is often recommended for short-term use to relieve constipation rather than daily supplementation.

Both forms are highly bioavailable, meaning they are well-absorbed by the body. However, bisglycinate's chelated structure provides superior cellular uptake and more consistent absorption without the laxative side effects that can affect citrate.

Both forms can help with muscle cramps. However, some prefer magnesium bisglycinate for nightly cramps due to its calming effects and gentle nature. Citrate's quick absorption can also offer faster relief for sudden discomfort.

While some people notice improved sleep and relaxation within a few days, full benefits for anxiety and muscle tension may take 4-6 weeks of consistent daily supplementation to become fully apparent.

References

  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.