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Understanding the Six Sugar Substitutes Approved by the FDA and Their Brand Names

4 min read

As of early 2025, the U.S. Food and Drug Administration (FDA) has officially approved six high-intensity sweeteners as food additives for general use. This approval is based on extensive scientific reviews to ensure safety for the general population under specific conditions.

Quick Summary

A guide detailing the six FDA-approved sugar substitutes, their popular brand names, and key characteristics. It offers information on sweetness levels, common uses, and safety considerations.

Key Points

  • Saccharin: The oldest FDA-approved sweetener, known by brand names like Sweet'N Low, and is heat-stable but can leave an aftertaste.

  • Aspartame: Marketed as Equal and NutraSweet, it contains calories but is used in minute amounts. It is not heat-stable and should be avoided by individuals with PKU.

  • Acesulfame Potassium (Ace-K): Sold as Sweet One and Sunett, this non-caloric, heat-stable sweetener is often blended with others to enhance flavor.

  • Sucralose: The active ingredient in Splenda, it is 600 times sweeter than sugar and is heat-stable and versatile for cooking and baking.

  • Neotame: An extremely potent, heat-stable derivative of aspartame, known by the brand Newtame, that does not pose a risk for people with PKU.

  • Advantame: The most potent FDA-approved sweetener, this heat-stable flavor enhancer is used in tiny quantities and does not require a PKU warning label.

In This Article

Navigating the World of High-Intensity Sweeteners

In the ever-expanding world of food and nutrition, sugar substitutes offer an alternative for those looking to reduce their sugar and calorie intake. The six sweeteners approved as food additives by the FDA are a result of rigorous scientific review, confirming their safety for consumption within the established guidelines. These high-intensity sweeteners are many times sweeter than table sugar, meaning only a very small amount is needed to achieve the desired sweetness level without adding significant calories.

1. Saccharin

Saccharin is one of the oldest and most widely used non-nutritive sweeteners, with its use regulated by the FDA since 1977.

  • Brand Names: Sweet'N Low®, Sweet Twin®, Necta Sweet®.
  • Sweetness Intensity: 200 to 700 times sweeter than sucrose.
  • Characteristics: It is heat-stable and has no calories. It may have a slightly bitter or metallic aftertaste, especially at higher concentrations.
  • Uses: Used in a wide variety of products, including beverages, candies, cookies, and tabletop sweeteners.

2. Aspartame

Composed of two amino acids, aspartic acid and phenylalanine, aspartame is digested by the body like other protein-based foods. People with the rare genetic disorder phenylketonuria (PKU) must monitor their intake.

  • Brand Names: NutraSweet®, Equal®, Sugar Twin®.
  • Sweetness Intensity: Approximately 200 times sweeter than sugar.
  • Characteristics: Contains four calories per gram but is used in such small amounts that it is virtually calorie-free. It is not heat-stable and loses sweetness when cooked.
  • Uses: Common in diet sodas, sugar-free chewing gum, instant desserts, and tabletop sweeteners.

3. Acesulfame Potassium (Ace-K)

Discovered in Germany, Ace-K is a non-caloric sweetener often used in combination with other sweeteners to create a more sugar-like taste profile.

  • Brand Names: Sweet One®, Sunett®.
  • Sweetness Intensity: Approximately 200 times sweeter than sucrose.
  • Characteristics: Exceptionally heat-stable, making it suitable for baking. It is not metabolized by the body and is excreted unchanged.
  • Uses: Found in baked goods, chewing gum, dairy desserts, beverages, and tabletop sweeteners.

4. Sucralose

Made from a process that starts with regular table sugar, sucralose is modified to be non-caloric and significantly sweeter.

  • Brand Name: Splenda®.
  • Sweetness Intensity: About 600 times sweeter than sugar.
  • Characteristics: Highly stable under heat and across a wide range of pH levels, making it versatile for cooking and baking.
  • Uses: A general-purpose sweetener in a vast number of products, from baked goods and beverages to dairy items and chewing gum.

5. Neotame

Neotame is a derivative of aspartame but with key structural differences that make it far sweeter and more stable. The amount of phenylalanine released is negligible, so products containing neotame do not require a PKU warning label.

  • Brand Name: Newtame®.
  • Sweetness Intensity: 7,000 to 13,000 times sweeter than sucrose.
  • Characteristics: Extremely potent and heat-stable, allowing for use in baked goods and other applications requiring high heat.
  • Uses: General-purpose sweetener and flavor enhancer in a wide range of foods and beverages, excluding meat and poultry.

6. Advantame

The most recently approved of the six, advantame is an exceptionally potent sweetener and flavor enhancer. Like neotame, it is heat-stable and does not require a PKU warning label.

  • Brand Name: Advantame®.
  • Sweetness Intensity: Up to 20,000 times sweeter than table sugar.
  • Characteristics: Highly potent and stable, it is suitable for use in high-temperature processes like baking.
  • Uses: General-purpose sweetener and flavor enhancer in food, excluding meat and poultry.

Comparison of FDA-Approved High-Intensity Sweeteners

Feature Saccharin Aspartame Acesulfame Potassium (Ace-K) Sucralose Neotame Advantame
Sweetness 200-700x ~200x ~200x ~600x 7,000-13,000x ~20,000x
Brand Names Sweet'N Low, Necta Sweet Equal, NutraSweet Sunett, Sweet One Splenda Newtame Advantame
Caloric Content Zero 4 cal/g* Zero Zero Zero Zero
Heat Stability Stable Not Stable Stable Stable Stable Stable
Use Case Tabletop, baking, beverages Tabletop, cereals, gum, beverages (not baked goods) Baking, beverages, dairy, tabletop Baking, beverages, sauces, dairy, general purpose Baking, beverages, frozen desserts, general purpose Baking, beverages, general purpose
Special Considerations May have aftertaste PKU warning required, not for baking Often blended with other sweeteners Very versatile, sugar-like taste Does not require PKU warning Most potent, does not require PKU warning

*Aspartame contains calories, but is used in amounts so small that it is considered non-caloric in practice.

Making an Informed Decision

Choosing the right sugar substitute often depends on a person's specific dietary needs and preferences. For those with PKU, options like sucralose or neotame are safer than aspartame. If you need a heat-stable option for baking, saccharin, Ace-K, sucralose, neotame, or advantame are all suitable choices. For a clean, sugar-like flavor without significant aftertaste, sucralose is a popular option. Advantame offers the highest sweetness intensity for cost-effective reformulation of low-calorie products. Consumers should always check product labels for ingredients to make the best choice for their health. A great resource for additional information on sweeteners can be found on the FDA website.

In conclusion, the FDA's approval of these six sugar substitutes offers consumers a range of options for controlling their sugar and calorie intake while maintaining sweet flavors. Each has a unique profile in terms of sweetness, stability, and usage, providing flexibility for different food and beverage applications. By understanding these options, you can make more informed choices that align with your health goals.

Frequently Asked Questions

The six sweeteners approved by the FDA as food additives are saccharin, aspartame, acesulfame potassium (Ace-K), sucralose, neotame, and advantame.

Saccharin, acesulfame potassium (Ace-K), sucralose, neotame, and advantame are all heat-stable, making them suitable for use in baking and cooking.

Individuals with phenylketonuria (PKU) should avoid or limit their consumption of aspartame, as it contains the amino acid phenylalanine, which they have difficulty metabolizing.

The most widely known brand name for sucralose is Splenda®.

Yes, neotame is considered safe for people with PKU because its molecular structure prevents the release of significant amounts of phenylalanine during digestion, unlike aspartame.

Acesulfame potassium (Ace-K) is commonly sold under the brand names Sweet One® and Sunett®.

The intensity varies greatly among the six, ranging from saccharin and aspartame at about 200 times sweeter than sugar, to advantame, which is up to 20,000 times sweeter.

Only aspartame contains a measurable amount of calories (4 per gram), but because it is so intensely sweet, it is used in such small quantities that its caloric contribution is negligible.

Purified extracts of steviol glycosides (stevia) and monk fruit are generally recognized as safe (GRAS) by the FDA, a separate classification from the six approved food additives. Unpurified or crude versions are not permitted.

Advantame is the most potent of the six FDA-approved sweeteners, at up to 20,000 times sweeter than sugar.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.