What Are The Ingredients In Folate Forte?

December 28, 2025 •

4 min read

While the term “folate forte” is not standardized across the industry, a prominent version by Jarrow Formulas includes the active forms of folate, B12, and B6. The specific ingredients in folate Forte depend heavily on the manufacturer, with variations in the type and potency of B vitamins used.

Quick Summary

Folate Forte formulas typically feature high-potency, active B vitamins like methylfolate, methylcobalamin (B12), and pyridoxal-5-phosphate (B6). Ingredients vary by brand, with some including a broader range of B vitamins or synthetic folic acid, alongside excipients.

Key Points

Methylfolate: Folate Forte formulations, especially from Jarrow Formulas, typically use active methylfolate (L-Methylfolate) instead of synthetic folic acid.
Active B Vitamins: Besides folate, many Folate Forte supplements include other active B vitamins, such as methylcobalamin (B12) and pyridoxal-5-phosphate (B6).
Manufacturer Variation: The exact ingredients differ significantly between brands; for example, iNova's "Folic Acid Forte" contains a wide range of synthetic B vitamins.
MTHFR Gene Considerations: Active methylfolate is often recommended for individuals with MTHFR gene mutations, who may have difficulty converting synthetic folic acid.
Purpose-Specific Blends: Some products, like "Mom Folic Forte," are formulated with specific ingredients like inositol for targeted health goals, such as reproductive support.

The Core Active Ingredients in Jarrow Formulas' Folate Forte

One of the most recognized products using this name is Jarrow Formulas' Folate Forte, which stands out for its use of methylated or coenzyme forms of B vitamins. This is particularly beneficial for individuals with genetic variations in the MTHFR enzyme, which can impair the body's ability to convert synthetic folic acid into its usable form.

Methyl Folate (L-Methylfolate)

Instead of synthetic folic acid, Jarrow Formulas' product utilizes methyl folate, specifically as Quatrefolic® ((6S)-5-methyltetrahydrofolate glucosamine salt). This is the active form of folate that the body can use directly without the need for conversion. Its primary functions include supporting DNA synthesis, promoting healthy cell growth, and aiding in the metabolism of homocysteine.

Methyl B12 (Methylcobalamin)

Methylcobalamin is the active, coenzyme form of vitamin B12 found in this formula. It works synergistically with methyl folate to support crucial biological processes. These include red blood cell formation, neurological function, and the methylation cycle. The combination of active folate and B12 is key for those concerned with genetic variations that affect methylation.

Vitamin B6 (Pyridoxal-5-Phosphate or P-5-P)

P-5-P is the coenzyme form of vitamin B6, which is directly usable by the body. B6 is vital for amino acid metabolism, red blood cell production, and the creation of neurotransmitters. Its inclusion in the Folate Forte formula provides comprehensive support for metabolic and neurological health.

List of Inactive Ingredients in Jarrow Formulas Folate Forte

Calcium phosphate: A binding and filling agent.
Cellulose: A plant-based fiber used as a binder.
Guar gum: A natural gum used as a thickening agent.
Silicon dioxide: An anti-caking agent to prevent ingredients from clumping.
Magnesium stearate (vegetable source): An ingredient that prevents the tablet from sticking to manufacturing equipment.
Food-grade coating: A protective and easy-to-swallow coating.

Variations in Folate Forte Formulations by Different Brands

The term “Forte” simply means strong or potent, so other manufacturers have their own proprietary blends under similar names. It is essential to read the supplement facts label for each specific product.

iNova Pharmaceuticals' Folic Acid Forte

This product, in contrast to the Jarrow formula, includes a broader spectrum of B vitamins and uses synthetic folic acid. Its ingredient list is comprehensive and includes:

Folic Acid (Synthetic)
Vitamin B1 (Thiamine mononitrate)
Vitamin B2 (Riboflavin)
Vitamin B3 (Nicotinamide)
Vitamin B5 (Calcium d-pantothenate)
Vitamin B6 (Pyridoxine hydrochloride)
Vitamin B12 (Cyanocobalamin)
Vitamin C (Ascorbic acid)

Atco Pharma's Mom Folic Forte Sachet

This is a reproductive support supplement aimed at women. Its ingredients are tailored to this purpose and differ significantly from other formulas:

L-Methylfolate (100mcg)
D-Chiro-Inositol (50mg)
Myo-Inositol USP (1000mg)

Folate Forte vs. Standard Folic Acid

Knowing the difference between various folate-containing supplements is crucial for making an informed choice, especially for those with specific health needs. The term "forte" does not guarantee the use of active, methylated folate.


Feature	Folate Forte (Jarrow Formulas Example)	Standard Folic Acid Supplement
Primary Folate Form	Active L-Methylfolate (Quatrefolic®)	Synthetic Folic Acid
Vitamin B12 Form	Active Methylcobalamin	Synthetic Cyanocobalamin
Vitamin B6 Form	Active Pyridoxal-5-Phosphate (P-5-P)	Synthetic Pyridoxine Hydrochloride
Body Conversion	No conversion needed; directly usable	Requires conversion via MTHFR enzyme
Bioavailability	High bioavailability	Highly bioavailable but depends on enzyme function
Considerations	Ideal for those with MTHFR mutations	May not be fully utilized by those with MTHFR mutations

How to Choose the Right Supplement

When selecting a folate supplement, consider the following:

Health Needs: For general health, a standard folic acid or B-complex might suffice. For pregnancy planning or certain health conditions, a discussion with a healthcare provider about active forms like methylfolate is essential.
MTHFR Gene Status: If you have a variation in the MTHFR gene, a supplement with methylfolate is often recommended to bypass the conversion step.
Read the Label: Always examine the supplement facts label to confirm the specific forms of B vitamins included, as the term "forte" is not a guarantee of active ingredients.

For more information on folate and folic acid labeling, you can consult resources from the U.S. Food and Drug Administration (FDA).

Conclusion

While the term "folate Forte" suggests a potent formula, its specific ingredients vary by manufacturer. A highly regarded version, such as Jarrow Formulas', is distinguished by its use of the active, methylated forms of folate, B12, and B6. Other products, like iNova's, may contain a wider range of B vitamins but use synthetic folic acid. It is crucial to review the product label and consult with a healthcare professional to choose the most suitable formulation for your specific health needs, especially considering genetic factors like the MTHFR variation.

Frequently Asked Questions

Folate Forte often refers to a high-potency formula containing active, methylated B vitamins like L-Methylfolate, Methylcobalamin, and P-5-P. Standard folate can refer to naturally occurring folate from food or synthetic folic acid, which must be converted by the body before it can be utilized.

No, they are different. Folic acid is the synthetic, man-made form of vitamin B9, while folate Forte formulations often contain active methylfolate, the form the body uses directly. The term Forte indicates a powerful or complex formula, not necessarily synthetic folic acid.

Yes, many folate Forte products that contain methylfolate are designed for people with MTHFR mutations. The active methylfolate bypasses the need for the MTHFR enzyme, allowing for better absorption and utilization of the vitamin.

No, the ingredients are not standardized and can vary greatly by brand. You should always read the product label to see the specific forms and quantities of vitamins and other components included.

Inactive ingredients, or excipients, vary by product. For Jarrow Formulas' version, these include calcium phosphate, cellulose, and magnesium stearate. These are used as fillers, binders, and to aid in manufacturing.

The main benefit is improved bioavailability, especially for individuals who have trouble converting synthetic forms into their active states due to genetic factors. The body can use active forms like methylfolate and methyl B12 immediately.

Yes, many foods naturally contain folate, such as leafy green vegetables, beans, and fruits. However, fortified foods contain synthetic folic acid, which is more stable. A supplement like folate Forte may be necessary to meet specific nutritional needs.