Understanding Nattokinase
Nattokinase is a serine protease enzyme extracted from natto, a traditional Japanese food made from fermented soybeans. It gained recognition in 1987 when Japanese researcher Hiroyuki Sumi discovered its potent fibrinolytic properties. It can degrade fibrin, a protein involved in blood clotting, which may contribute to better circulatory health. However, not all nattokinase supplements are created equal. The market contains a wide range of products with significant variations in quality, potency, and safety.
Key Considerations When Buying Nattokinase
To ensure you purchase a high-quality, effective product, pay close attention to the following criteria:
1. Potency (FU - Fibrinolytic Units) The activity of nattokinase is measured in Fibrinolytic Units (FU), which indicates its ability to break down fibrin. A higher FU count per serving suggests a stronger enzymatic effect. The appropriate amount can vary based on individual needs and the specific product. Many studies utilize amounts around 2,000 FU per day when investigating effects on blood pressure and clotting factors. Some products offer higher potencies, which can be a consideration depending on the intended use. Supplements that only list the milligram amount without the FU value are less reliable as they do not confirm the enzyme's active strength.
2. Source and Purity (Vitamin K2 Removal) Authentic, high-quality nattokinase is derived from the fermentation of non-GMO soybeans using Bacillus subtilis natto. Many leading manufacturers use the patented NSK-SD® brand, which is known for being free of vitamin K2. This is a critical factor because vitamin K2 promotes blood clotting, which could counteract the intended effects of nattokinase. NSK-SD® also has an extensive history of clinical studies supporting its safety and efficacy. Ensuring your supplement explicitly states it is vitamin K2-free is a vital step in your selection process, especially if you are taking blood-thinning medication. Always check the product label for the source of the nattokinase and whether it contains vitamin K2.
3. Third-Party Testing and Certification Independent third-party testing is essential for ensuring supplement quality, as it verifies that the product's contents match its label and are free from contaminants. Look for certification seals from reputable organizations, such as NSF International, USP (United States Pharmacopeia), or the Japan Nattokinase Association (JNKA). A JNKA seal guarantees that the product is authentic nattokinase and meets specific quality standards, helping to avoid counterfeit products.
4. Form of Supplement Nattokinase is most commonly available in capsule form. High-quality capsules, especially those with an enteric coating or delayed-release formulation, protect the enzyme from being destroyed by stomach acid before it can be absorbed in the small intestine. This ensures that the optimal amount of active nattokinase reaches your bloodstream. Powdered forms are also available but may be less protected from stomach acid unless specifically formulated otherwise.
5. Added Ingredients and Fillers Examine the "Other Ingredients" section of the supplement label. Some formulations combine nattokinase with complementary ingredients like serrapeptase, bromelain, or CoQ10 to enhance cardiovascular support. These combinations can offer broader health benefits. Conversely, beware of supplements that contain unnecessary fillers, binders, or artificial additives that offer no therapeutic value and may indicate a lower-quality product.
Comparison Table: Factors for Choosing Nattokinase
| Feature | High-Quality Nattokinase | Lower-Quality Nattokinase |
|---|---|---|
| Potency (FU) | Clearly lists FU count; often features amounts around 2,000 FU per serving. | May list only milligrams, or have a vague, low FU count. |
| Source/Purity | Derived from non-GMO soy and labeled Vitamin K2-free (e.g., NSK-SD®). | Source is unclear, may contain Vitamin K2, or come from non-traditional fermentation. |
| Testing | Certified by third parties like JNKA, USP, or NSF. | Lacks independent verification or relies solely on manufacturer claims. |
| Formulation | Enteric-coated or delayed-release veggie capsules for optimal absorption. | Standard capsules or tablets that may be damaged by stomach acid. |
| Ingredients | Minimal fillers, may include synergistic ingredients (e.g., bromelain). | Contains unnecessary fillers, binders, or artificial additives. |
Potential Drug Interactions and Safety
While nattokinase is generally well-tolerated, it is crucial to consult a healthcare provider before use, especially if you have pre-existing health conditions or take other medications. Nattokinase may interact with blood-thinning medications like warfarin, leading to an increased risk of bruising or bleeding. It should also be discontinued at least two weeks before any scheduled surgery. Pregnant and breastfeeding women should avoid nattokinase due to a lack of safety data.
Conclusion
Choosing the right nattokinase supplement requires careful research beyond just the price tag. By prioritizing potency (FU), purity (especially vitamin K2 removal and NSK-SD® brand), and independent third-party testing, you can ensure you are investing in a product that is both safe and effective. Always read the label thoroughly, consider the supplement form, and discuss any potential interactions with your healthcare provider to make the most informed decision for your cardiovascular health. Taking these steps will help you confidently select a high-quality nattokinase supplement that aligns with your health goals.
