A Tale of Two Complements: Nattokinase and K2
Nattokinase and Vitamin K2 are both derived from the fermented soybean dish known as natto, a staple in Japanese cuisine. However, the relationship between these two compounds is often misunderstood because of their distinct physiological roles. On one hand, nattokinase is primarily known for its fibrinolytic properties, meaning it helps to break down fibrin, a protein involved in blood clot formation. On the other hand, vitamin K2 is essential for activating proteins that aid in proper blood clotting and directing calcium to the bones while keeping it out of the arteries. Instead of canceling each other out, these two work in complementary ways to support overall cardiovascular health.
The Distinct Roles of Nattokinase and K2
To understand why these compounds work well together, it is important to first distinguish their individual functions.
Nattokinase: This enzyme acts as a natural "clot buster" by dissolving fibrin. This process is critical for maintaining healthy blood flow and circulation. By breaking down excess fibrin, nattokinase helps to prevent unnecessary blood clots, which can improve overall blood viscosity and reduce the risk of cardiovascular events like heart attacks and strokes. Studies have also indicated that nattokinase may help lower blood pressure in individuals with hypertension.
Vitamin K2: In contrast, Vitamin K2 (specifically the MK-7 form) plays a vital role in regulating calcium. It activates matrix Gla protein (MGP), which prevents calcium from accumulating in the arteries, thereby reducing arterial stiffness and calcification. It also activates osteocalcin, a protein that integrates calcium into bone, promoting strong bones and a healthy vascular system. While Vitamin K2 does support the coagulation process, it works in a different pathway than nattokinase’s clot-dissolving action.
Synergistic Benefits for Cardiovascular Health
The co-existence of nattokinase and vitamin K2 in natto points to a natural synergy, where each compound addresses a different aspect of cardiovascular health, leading to a more comprehensive benefit than either could offer alone.
- Improved Blood Flow and Vascular Elasticity: Nattokinase helps clear the path by breaking down blood clots, while K2 keeps the arterial walls clear of calcium buildup, ensuring smooth and flexible vessels for better circulation.
- Balanced Approach to Blood Clotting: The body needs to be able to form clots when necessary, such as for wound healing. K2 ensures this normal process, while nattokinase prevents the formation of excessive or unnecessary clots, maintaining a healthy balance.
- Bone Health and Arterial Health: The calcium-directing function of K2 benefits both skeletal health and vascular health, complementing nattokinase's action on blood viscosity.
Comparison of Nattokinase and Vitamin K2 Functions
| Feature | Nattokinase | Vitamin K2 (MK-7) |
|---|---|---|
| Source | Fermented soybeans (natto) | Fermented soybeans (natto), cheese, animal products |
| Primary Function | Fibrinolytic enzyme (dissolves clots) | Activates calcium-regulating proteins |
| Effect on Blood Clotting | Inhibits excessive clotting | Supports proper coagulation factors |
| Target System | Bloodstream, circulation | Arteries, bones |
| Key Benefit | Improved blood flow, reduced blood pressure | Arterial health, bone density |
| Timing for Efficacy | Affects clotting factors within hours | Effects on bone and arteries take longer, weeks to months |
Proper Administration and Safe Co-administration
When considering supplementation, particularly a combination product, proper administration and timing are key. Nattokinase is typically measured in Fibrinolytic Units (FU). Vitamin K2 (MK-7) is typically measured in micrograms. Many manufacturers offer supplements that combine both for convenience. Some experts suggest taking nattokinase on an empty stomach for optimal absorption, while fat-soluble Vitamin K2 is better absorbed with food. For combination products, following the manufacturer's directions is best, but individuals should still consider their dietary intake and other supplements.
Critical Safety Considerations and Precautions
While the combination is generally safe for healthy individuals, it is not suitable for everyone. It is absolutely crucial to consult a healthcare provider before starting a combined regimen, particularly for those with underlying health conditions or taking certain medications. This is especially important for individuals on blood-thinning medications like warfarin, as both nattokinase and K2 can impact how these drugs work.
- Who Should Avoid the Combination?
- Anyone on blood-thinning medication (anticoagulants or antiplatelet drugs).
- Individuals with a history of bleeding disorders.
- Anyone with very low blood pressure.
- Pregnant or breastfeeding women, due to limited research.
- Individuals undergoing surgery; nattokinase should be discontinued at least one week prior.
Conclusion: A Beneficial Partnership for Many
In summary, the question of "can you take nattokinase and k2 together?" has a positive answer for many. The two compounds, with their distinct yet complementary mechanisms, offer a synergistic approach to supporting cardiovascular and bone health. While nattokinase promotes healthy blood viscosity and flow by dissolving fibrin, vitamin K2 ensures proper calcium regulation, preventing arterial calcification. This makes them a compelling duo for those seeking to enhance their heart health naturally. However, the vital importance of consulting a healthcare professional cannot be overstated, especially for those on medications or with pre-existing conditions, to ensure safe and appropriate use. Learn more about nattokinase here.
The Role of Natto as a Whole Food Source
It's worth noting that the original source, natto, contains both compounds naturally. This fermented food not only provides nattokinase and K2 but also probiotics and other nutrients. For those able to tolerate the unique taste and texture, consuming natto itself is an integrated way to get both nutrients as nature intended. Many supplements have been created to isolate the benefits for those who find natto unpalatable, but checking the label for vitamin K-free options is important if you are on specific medications.
