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Which one is better, glycinate or citrate? A Guide to Choosing Your Magnesium

4 min read

According to some studies, over half of the population may have a marginal magnesium deficiency, a gap that supplements can help bridge. When navigating the vast world of supplements, magnesium glycinate and magnesium citrate are two popular forms, but their differing benefits and effects mean that 'better' is a relative term depending on your specific needs.

Quick Summary

Magnesium glycinate is a gentle, highly-absorbable form best suited for promoting relaxation, sleep, and muscle health, while magnesium citrate is a fast-acting osmotic laxative used primarily for relieving occasional constipation.

Key Points

  • Purpose is key: Glycinate is for relaxation and sleep, while citrate is for constipation relief.

  • Digestive tolerance differs: Glycinate is gentle on the stomach, whereas citrate has a stronger laxative effect.

  • Glycine provides added calm: The amino acid glycine in magnesium glycinate offers additional calming benefits for anxiety and sleep.

  • Citrate is for occasional use: Due to its laxative properties, citrate is best for short-term relief, not daily, long-term supplementation.

  • You can combine them: Some people use citrate for digestive support and glycinate for nightly relaxation.

In This Article

Understanding Magnesium: The Body's Essential Mineral

Magnesium is a vital mineral involved in over 300 enzymatic reactions in the human body, playing a crucial role in everything from muscle and nerve function to blood sugar control and protein synthesis. A deficiency can lead to a host of issues, including muscle cramps, fatigue, and difficulty sleeping. With many people not getting enough magnesium from their diets, supplementation has become a popular way to ensure adequate intake. However, not all magnesium supplements are created equal, with different forms offering unique benefits.

The Case for Magnesium Glycinate

Magnesium glycinate is a chelated form of magnesium, meaning it is bound to the amino acid glycine. This binding is what gives it distinct properties that make it a favorite for those seeking calming benefits.

Glycinate: A Gentle and Relaxing Option

The combination of magnesium and glycine provides a powerful synergistic effect. Glycine is a calming neurotransmitter that helps promote relaxation and improve sleep quality. This makes magnesium glycinate particularly well-suited for individuals dealing with:

  • Stress and Anxiety: It helps calm the nervous system and regulate stress hormones like cortisol.
  • Sleep Issues: The calming effect of glycine can help reduce the time it takes to fall asleep and improve overall sleep quality.
  • Muscle Tension: Its relaxing properties can help ease muscle cramps and stiffness.

Superior Absorption Without the Discomfort

Another significant advantage of magnesium glycinate is its high bioavailability and gentle nature on the digestive system. It is less likely to cause the loose stools and digestive upset that some other forms of magnesium are known for, making it an excellent choice for long-term daily supplementation. This means more magnesium is absorbed for systemic use and less is lost due to digestive side effects.

The Power of Magnesium Citrate

Magnesium citrate is a compound formed by combining magnesium with citric acid, a natural acid found in citrus fruits. While it also has high bioavailability, its primary and most well-known function is quite different from that of glycinate.

An Effective Laxative for Occasional Constipation

The key feature of magnesium citrate is its osmotic effect. As a saline laxative, it works by drawing water into the intestines, which softens the stool and promotes a bowel movement. This makes it a go-to option for:

  • Occasional Constipation Relief: It can provide fast-acting relief, often within 30 minutes to 6 hours.
  • Bowel Preparation: Higher doses are used under medical supervision to clear the bowels before a colonoscopy or other procedures.

Potential for Digestive Discomfort

For those not seeking a laxative effect, magnesium citrate can be problematic. At higher doses, or for those with a sensitive digestive system, it can cause loose stools, diarrhea, and stomach cramping. For this reason, it is generally not recommended for daily, long-term use unless specifically treating chronic constipation under a doctor's guidance.

Glycinate vs. Citrate: A Head-to-Head Comparison

To help clarify the differences, here is a direct comparison of magnesium glycinate and magnesium citrate:

Feature Magnesium Glycinate Magnesium Citrate
Primary Use Relaxation, anxiety, sleep, muscle tension, general supplementation Occasional constipation relief, bowel cleanse
Key Characteristic Bound to glycine, a calming amino acid Bound to citric acid, a natural laxative
Digestive Impact Very gentle on the stomach, minimal risk of diarrhea Can cause loose stools and digestive discomfort, especially at higher doses
Bioavailability High, well-absorbed for systemic benefits High, but also draws water into the bowels
Ideal Timing Evening, 30-60 minutes before bed, for relaxation Often taken as needed for digestive regularity; some take it in the morning
Side Effects Rare, some may experience drowsiness Diarrhea, stomach cramps, nausea, especially at high doses

Choosing the Right Form for Your Health Goals

Your choice between glycinate and citrate should align with your primary health objectives.

  • If your goal is better sleep, reduced anxiety, or general relaxation, magnesium glycinate is the superior choice. Its gentle nature and the added calming effect from glycine make it ideal for consistent, long-term use without causing digestive upset. It effectively addresses stress-related symptoms and supports a calm nervous system.

  • If you are looking for an effective, short-term solution for occasional constipation, magnesium citrate is your best bet. Its potent laxative effect can provide quick relief when needed. For this purpose, it should not be used as a daily, ongoing supplement.

Can You Take Glycinate and Citrate Together?

For some individuals, a combination of both can be beneficial. For example, a person might use magnesium citrate for occasional constipation and rely on magnesium glycinate for daily calming support. Many people find success by taking citrate in the morning if needed for regularity and glycinate in the evening to wind down for bed. Always consult with a healthcare provider before combining supplements, especially if you have pre-existing health conditions or are on other medications.

How to Take Your Supplement for Maximum Benefit

To maximize the effectiveness and minimize potential side effects of either supplement, consider these guidelines:

  • Start with a lower dose to assess your body's tolerance, especially with magnesium citrate.
  • Take with food to further reduce the risk of digestive discomfort.
  • Stay hydrated by drinking plenty of water, which is especially important when using citrate.
  • Be patient with glycinate, as its effects on sleep and anxiety may take several weeks of consistent use to become noticeable.

Conclusion: Making Your Choice

Ultimately, there is no single 'better' magnesium supplement between glycinate and citrate. The right choice is entirely dependent on your individual health needs and desired outcome. Glycinate excels as a calming, gentle, and highly-absorbable daily supplement for stress, anxiety, and sleep. Citrate, with its potent osmotic effect, is the clear winner for providing fast and effective relief from occasional constipation. By understanding these key differences, you can confidently choose the magnesium supplement that will best support your journey toward better health. For further research on supplement bioavailability, refer to studies like this one on the comparative bioavailability of different magnesium compounds.

Frequently Asked Questions

Magnesium glycinate is the superior choice for sleep due to its binding with the amino acid glycine, which has natural calming properties that help improve sleep quality and duration.

Magnesium citrate is more effective for relieving constipation because it acts as an osmotic laxative, drawing water into the intestines to soften stools and stimulate bowel movements.

Both glycinate and citrate are considered highly bioavailable, meaning they are well-absorbed by the body, especially when compared to less soluble forms like magnesium oxide. However, their effects in the body differ.

Yes, some people combine both, as they serve different purposes. For instance, you could take citrate in the morning for digestive support and glycinate at night for relaxation and sleep.

Magnesium glycinate is better for anxiety and stress due to its calming effects on the nervous system, enhanced by the amino acid glycine. It helps regulate neurotransmitters and stress hormones.

Magnesium citrate can cause stomach upset, cramping, and diarrhea, particularly at higher doses, because of its strong laxative effect. Magnesium glycinate is a much gentler alternative for those with sensitive stomachs.

Magnesium citrate typically works quite quickly, often producing a bowel movement within 30 minutes to 6 hours after ingestion. It's recommended to be near a restroom during this time.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.