Skip to content

Is calcium bisglycinate better than calcium citrate? A complete comparison

5 min read

Multiple studies indicate that calcium bisglycinate has significantly higher bioavailability than other forms, with one source suggesting it is 1.8 times better absorbed than calcium citrate. This critical difference is at the heart of the question: is calcium bisglycinate better than calcium citrate?

Quick Summary

A comprehensive comparison of calcium bisglycinate and calcium citrate covering absorption, gastric dependency, side effects, and cost to guide your supplement choice effectively.

Key Points

  • Absorption: Calcium bisglycinate generally offers higher bioavailability and is better absorbed than calcium citrate.

  • Stomach Acid: Neither bisglycinate nor citrate requires high levels of stomach acid for absorption, making them suitable for many individuals.

  • Side Effects: Bisglycinate is a gentler, chelated form, less likely to cause common GI issues like constipation than other forms.

  • Cost: Bisglycinate is typically more expensive, while citrate offers good absorption at a more accessible price point.

  • Dosage: For optimal absorption of any calcium supplement, doses should be split and kept under 500mg at a time.

  • Individual Needs: The best choice depends on personal factors like digestive tolerance, budget, and overall health status.

In This Article

Understanding Calcium Supplements

Calcium is a vital mineral essential for building and maintaining strong bones, nerve function, and proper muscle and heart health. When dietary intake falls short, supplements are a common way to bridge the gap. However, not all calcium supplements are created equal. The form of calcium dictates its absorption and how your body can utilize it. The two popular options often compared are calcium bisglycinate and calcium citrate.

Calcium Bisglycinate: The Chelate Advantage

Calcium bisglycinate is a chelated form of calcium, meaning the mineral is bound to two (bis) molecules of the amino acid glycine. This chelation process offers several distinct advantages, primarily related to its superior absorption and gentle effect on the digestive system.

Key benefits of bisglycinate:

  • High Bioavailability: Studies have shown that chelated forms like bisglycinate are highly bioavailable and easily absorbed by the body. The stable bond with glycine prevents the calcium from dissociating in the stomach, which means less interference from dietary inhibitors like phytic acid.
  • pH Stability: Unlike some other calcium forms, bisglycinate is pH stable, maintaining its integrity even in the acidic environment of the stomach.
  • Does Not Require Stomach Acid: Because it does not rely on stomach acid for absorption, it is an ideal choice for individuals with reduced stomach acid levels, which is common in older adults or those taking acid-blocking medications.
  • Reduced Side Effects: This form is often associated with fewer gastrointestinal side effects, such as constipation and bloating, which are common issues with less bioavailable calcium sources like calcium carbonate.

Calcium Citrate: The Acid-Independent Option

Calcium citrate is another widely used supplement, combining calcium with citric acid. It has a proven track record and offers specific benefits, particularly for those with digestive sensitivities or certain medical conditions.

Key benefits of citrate:

  • Equal Absorption With or Without Food: One of its main advantages is that it is absorbed equally well whether taken with or without food.
  • Suitable for Low Stomach Acid: Like bisglycinate, calcium citrate also does not require significant stomach acid for absorption, making it a viable option for those with low gastric acidity.
  • Less Likely to Cause GI Side Effects: It is known to cause fewer gastrointestinal side effects compared to calcium carbonate.
  • Widely Available: Calcium citrate is a well-researched and commonly available form of calcium supplement.

Head-to-Head Comparison: Bisglycinate vs. Citrate

To help clarify which option may be better for your individual needs, let's examine the differences side-by-side.

Feature Calcium Bisglycinate Calcium Citrate
Absorption Very high bioavailability, potentially 1.8x better absorbed than citrate. Good bioavailability, though generally considered lower than bisglycinate.
Stomach Acid Dependent? No, absorbed effectively regardless of stomach acid levels. No, absorbed well even with low stomach acid.
Elemental Calcium Content Varies by formulation; typically lower elemental calcium per dose. Lower elemental calcium (approx. 21%) compared to carbonate, meaning more tablets may be needed.
Digestive Tolerance Gentle on the stomach; less likely to cause constipation or bloating. Less likely to cause GI side effects than calcium carbonate.
Chelated Form Yes, bound to the amino acid glycine, which can aid absorption. No, a salt of citric acid.
Cost Generally more expensive due to the chelation process. Often more affordable than chelated forms like bisglycinate.

Factors to Consider When Choosing

When deciding between calcium bisglycinate and calcium citrate, several factors should influence your decision beyond just the absorption rate. It's about finding the right balance for your body and your budget.

  • Digestive Sensitivity: If you have a sensitive stomach or have experienced side effects like bloating or constipation with other calcium supplements (like calcium carbonate), both bisglycinate and citrate are good options. However, some report that the gentle chelated nature of bisglycinate can be even easier on the digestive system.
  • Stomach Acid Levels: For individuals with naturally low stomach acid, or those using acid blockers, both supplements are suitable, as neither requires high levels of gastric acid for absorption. The chelation process in bisglycinate may offer a slight edge in absorption stability.
  • Cost vs. Bioavailability: Calcium bisglycinate is typically more expensive, but its potentially higher absorption means you may need a smaller dose to achieve the same effect. Calculate the cost per milligram of elemental calcium absorbed to see the true value. For many, the higher absorption and gentler side-effect profile of bisglycinate justify the higher price.
  • Dosage and Schedule: Regardless of which form you choose, all calcium supplements are better absorbed when taken in smaller doses (500 mg or less) at different times of the day. Splitting your dose will maximize absorption and effectiveness.
  • Elemental Calcium Percentage: Remember that the elemental calcium percentage varies by form. While bisglycinate's chelated nature improves absorption, you may need to take more tablets of citrate to get a comparable amount of elemental calcium.

Conclusion: Making the Right Choice

The question of whether calcium bisglycinate is better than calcium citrate doesn't have a universal answer. For those seeking the highest possible absorption and superior digestive comfort, and who are not constrained by budget, calcium bisglycinate is likely the better choice due to its chelated structure and gentle nature. However, calcium citrate remains an excellent, well-absorbed alternative, particularly for those with low stomach acid who prioritize a more economical option. The optimal choice depends on your specific health needs, budget, and tolerance.

Ultimately, the best calcium supplement is one that your body absorbs well and that you can take consistently. For further reading, consult the reliable information available from medical authorities like the Mayo Clinic on selecting the right supplement for you.

Understanding the Chelation Process

Chelation is the process of binding a mineral to an organic compound, in this case, the amino acid glycine. This creates a highly stable molecule that can pass through the digestive system more effectively. Instead of relying on the body's digestive acids to separate the calcium, the chelated molecule is absorbed whole. This bypasses potential absorption inhibitors in food and can result in higher assimilation into the cells.

The Role of Stomach Acid

While calcium carbonate requires significant stomach acid for absorption, both bisglycinate and citrate are more forgiving. This is particularly relevant for older adults, as stomach acid production often decreases with age. For these individuals, choosing a supplement like bisglycinate or citrate is crucial for ensuring adequate calcium is absorbed, rather than just passing through the body.

The Importance of Dietary Calcium

While supplements are helpful, they are not a replacement for a calcium-rich diet. Sources include dairy products, fortified foods, and leafy green vegetables. Supplements should be used to complement a healthy diet, not to compensate for a poor one. Always prioritize obtaining nutrients from whole foods first.

Final Recommendations

Consulting with a healthcare professional is always recommended before starting a new supplement regimen. They can help determine your specific calcium needs and recommend the most appropriate form and dosage based on your health status, including any pre-existing conditions like inflammatory bowel disease or osteoporosis. They can also advise on potential interactions with other medications you may be taking.

Ultimately, the best choice is a personal one, weighing the benefits of superior absorption against factors like cost and availability. By understanding the differences, you are better equipped to make an informed decision for your bone health.

Frequently Asked Questions

Both calcium bisglycinate and calcium citrate are good choices for individuals with low stomach acid, as their absorption is not dependent on high levels of gastric acid. Calcium bisglycinate's chelated form may provide slightly more stable absorption.

The main difference lies in their chemical structure and absorption. Bisglycinate is a chelated form (bound to glycine) with superior bioavailability, while citrate is a calcium salt with good but potentially lower absorption rates.

Yes, many users report that calcium bisglycinate is gentler on the digestive system and less likely to cause constipation or bloating compared to calcium carbonate and sometimes even citrate, due to its high bioavailability and easy assimilation.

Generally, yes. The manufacturing process for chelated bisglycinate is more complex and expensive, which is reflected in the product price. Citrate is often a more budget-friendly option.

It depends on the form. Calcium bisglycinate and calcium citrate are absorbed well with or without food. However, taking any calcium supplement in doses of 500mg or less improves overall absorption.

Both calcium bisglycinate and citrate are beneficial for bone health and can support conditions like osteoporosis when combined with vitamin D. The 'best' choice depends on individual absorption, tolerance, and budget. Always consult a healthcare provider for personalized advice.

Elemental calcium refers to the actual amount of calcium in a supplement that your body can absorb. Calcium citrate has about 21% elemental calcium, while bisglycinate's percentage varies but is often lower by weight, though its absorption is higher.

References

  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.