Skip to content

Why Do I Feel Ill After Taking Zinc? Causes and Solutions

4 min read

According to research, high zinc intake can cause gastrointestinal distress, including nausea and vomiting. Feeling ill after taking zinc is a common issue that many people experience, and it is most often related to the dosage, timing, and form of the supplement. Understanding why this happens can help you mitigate these unpleasant symptoms and ensure you get the benefits of this essential mineral without the discomfort.

Quick Summary

Zinc supplements can cause nausea, stomach pain, and other digestive issues. This discomfort is often caused by taking high doses or consuming the supplement on an empty stomach. Strategies like proper timing with meals and choosing the right form can prevent side effects.

Key Points

  • Dosage is critical: Excessive zinc intake above 40 mg daily is a primary cause of nausea, stomach cramps, and other digestive distress.

  • Always take with food: Taking zinc on an empty stomach can directly irritate the gastric lining; eating with meals helps buffer this effect.

  • Form matters: Zinc sulfate is more likely to cause stomach upset than gentler forms like picolinate or citrate.

  • Monitor for copper deficiency: Long-term, high-dose zinc supplementation can inhibit copper absorption, leading to a dangerous mineral imbalance.

  • Avoid interactions: Do not take zinc at the same time as iron or calcium supplements, as they compete for absorption.

  • Stay hydrated: Drinking plenty of water with your supplement aids absorption and reduces the concentration of zinc in one spot in the stomach.

In This Article

Common Reasons You Feel Ill After Taking Zinc

Feeling sick after taking a zinc supplement is a surprisingly common occurrence. While zinc is an essential mineral vital for immune function, DNA synthesis, and wound healing, overconsumption or improper intake can lead to adverse reactions. Here are the primary culprits behind that ill feeling:

1. Taking Zinc on an Empty Stomach

This is perhaps the most frequent cause of nausea and stomach upset from zinc supplements. When a concentrated amount of zinc enters an empty stomach, it can directly irritate the stomach lining. This irritation triggers feelings of discomfort, which can range from mild indigestion to intense nausea and vomiting. The solution is simple: always take your zinc supplement with a meal or a small snack. Food acts as a buffer, preventing the direct irritation of the stomach wall.

2. Excessive Dosage

While zinc is beneficial, the adage "more is better" does not apply. The tolerable upper intake level (UL) for adults is 40 mg of elemental zinc per day. Consuming more than this amount can cause acute toxicity, leading to a range of unpleasant symptoms, including nausea, vomiting, stomach cramps, and headaches. For long-term use, excessive zinc intake can lead to more serious issues, such as copper deficiency and weakened immune function. Always check the label for the elemental zinc content and consult a healthcare professional before taking high-dose supplements.

3. Zinc-Induced Copper Deficiency

Taking very high doses of zinc over an extended period can lead to a deficiency in copper. Zinc and copper compete for absorption in the small intestine, and an excess of zinc can inhibit the uptake of copper. Copper is an essential mineral for red blood cell formation, immune function, and iron absorption. Symptoms of copper deficiency can mirror other illnesses and include fatigue, anemia, and neurological issues. If you've been taking high-dose zinc for a while and feel ill, this mineral imbalance could be the root cause.

4. The Form of Zinc Matters

Not all zinc supplements are created equal. The specific form of zinc can influence its tolerability and absorption. Some forms, like zinc sulfate, are more likely to cause gastrointestinal side effects than others.

5. Interaction with Medications and Other Nutrients

Zinc can interact with certain medications, including quinolone and tetracycline antibiotics, reducing their effectiveness. It can also interfere with the absorption of other minerals, like iron and calcium, if taken at the same time. This can contribute to a feeling of being unwell or experiencing digestive upset. Always space out the intake of these supplements and medications.

How to Prevent Feeling Ill After Taking Zinc

Fortunately, avoiding the unpleasant side effects of zinc is relatively straightforward. By adjusting your supplementation strategy, you can enjoy the health benefits without the discomfort.

Here is a list of best practices for taking zinc supplements:

  • Always take with food. Eating a meal or a small snack before taking your zinc supplement is the most effective way to prevent nausea. The food buffers the stomach lining and ensures a more gradual absorption of the mineral.
  • Choose a gentler form. If you have a sensitive stomach, consider switching to a form of zinc that is easier to absorb and less likely to cause irritation, such as zinc picolinate or zinc citrate.
  • Stick to recommended dosages. Do not exceed the recommended daily allowance (RDA) or the tolerable upper intake level (UL) of 40 mg without medical supervision. Start with a lower dose if you are sensitive and gradually increase as needed.
  • Space out nutrient intake. Avoid taking zinc at the same time as supplements containing high amounts of iron or calcium to ensure optimal absorption of all minerals.
  • Stay hydrated. Drinking plenty of water when you take your supplement can aid in absorption and prevent potential concentration-related stomach issues.
  • Consult a healthcare provider. If you experience persistent or severe side effects, or are unsure about your dosage, speak with a doctor or a registered dietitian. They can help determine if zinc supplementation is right for you and recommend the best approach.

Zinc Supplement Forms Comparison

Understanding the differences between common zinc supplement forms can help you make an informed decision and minimize the risk of side effects.

Feature Zinc Sulfate Zinc Gluconate Zinc Picolinate Zinc Citrate
Elemental Zinc Lower per dose Variable, common form High absorption Good absorption
Bioavailability Good Moderate Very Good Good
Stomach Irritation High risk, especially on empty stomach Moderate risk, common in lozenges Low risk Low to moderate risk
Common Use Cold remedies, treating deficiency Lozenges, general immunity General supplementation General supplementation
Best Taken With Food, due to high irritation risk Food Food is recommended but can be tolerated without Food is recommended

Conclusion

While feeling ill after taking zinc can be a frustrating experience, it is almost always preventable. The key is to be mindful of your dosage, the timing of your intake, and the specific form of zinc you are using. For most people, simply taking the supplement with a meal and staying within the recommended daily intake is enough to resolve any issues. Chronic or severe problems should prompt a consultation with a healthcare professional to rule out zinc toxicity or other mineral imbalances, particularly copper deficiency. By following these simple steps, you can harness the full benefits of this essential nutrient without the unwanted side effects.

Visit the National Institutes of Health's Office of Dietary Supplements for detailed information on zinc and other minerals

Frequently Asked Questions

Yes, taking a zinc supplement on an empty stomach is one of the most common reasons for feeling sick. It can cause nausea, vomiting, and stomach cramps by irritating the stomach lining directly.

Nausea and stomach discomfort from zinc are typically short-lived and resolve within a few hours of taking the supplement. The symptoms will often subside more quickly if you eat some food.

If you have a sensitive stomach, choosing a more bioavailable and less irritating form, such as zinc picolinate or zinc citrate, is best. Zinc sulfate is often the most irritating.

Yes, taking excessive amounts of zinc for a prolonged period can be dangerous. Acute symptoms include severe nausea and vomiting, while chronic overconsumption can lead to copper deficiency and a weakened immune system.

For most adults, it is recommended to not exceed the tolerable upper intake level of 40 mg of elemental zinc per day from all sources, including food and supplements.

Yes, zinc can interfere with the absorption of certain antibiotics, like quinolones and tetracyclines. Always consult a healthcare provider about potential interactions if you are on medication.

If zinc causes persistent or severe nausea, you should stop taking it and consult a healthcare professional. For mild discomfort, try taking it with a full meal and a large glass of water.

References

  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.