The Best Probiotic to Take Along with Antibiotics

January 9, 2026 •

3 min read

According to a 2012 review published in JAMA, probiotics have been shown to be effective in preventing and treating antibiotic-associated diarrhea. Choosing the best probiotic to take along with antibiotics is crucial for mitigating gut disruption and supporting your microbiome during and after treatment.

Quick Summary

Taking antibiotics can disrupt the gut microbiome, leading to side effects like diarrhea. Selecting specific, research-backed probiotic strains, such as Saccharomyces boulardii and Lactobacillus rhamnosus GG, can help mitigate these issues. Proper timing, usually spacing doses by at least two hours, and continued supplementation after the antibiotic course are essential for optimal gut recovery.

Key Points

Top Strains: Saccharomyces boulardii and Lactobacillus rhamnosus GG are highly recommended for use with antibiotics.
Proper Timing: Space probiotic doses at least two hours away from antibiotics to protect the bacteria.
Start Early, Finish Late: Begin probiotics with your first antibiotic dose and continue for several weeks after.
Beyond Supplements: Support gut recovery with prebiotic and fermented foods post-antibiotics.
C. Difficile Protection: Saccharomyces boulardii is particularly helpful for preventing recurrent C. difficile infections.
Seek Specifics: Choose products with specific, effective strains for the intended purpose.

Why Are Probiotics Necessary with Antibiotics?

Antibiotics are crucial for fighting bacterial infections but can disrupt the balance of bacteria in your gut. This can lead to side effects like diarrhea, bloating, and yeast overgrowth. Taking a targeted probiotic can help restore beneficial bacteria and reduce these risks. Selecting specific, clinically effective strains is key.

Top Probiotic Strains for Use with Antibiotics

Certain probiotic strains are well-supported by research for their ability to help manage gut issues caused by antibiotics.

Saccharomyces boulardii (S. boulardii)

S. boulardii is a yeast that is naturally resistant to antibiotics, making it a good option. It works by competing with harmful bacteria and supporting gut immune function. Studies show it significantly reduces antibiotic-associated diarrhea (AAD) and is effective in preventing C. difficile recurrence. It can often be taken closer to antibiotic doses, though spacing is generally recommended.

Lactobacillus rhamnosus GG (LGG®)

LGG is a well-studied bacterial strain known for helping with antibiotic-associated diarrhea. It adheres to the intestinal lining, helping protect and restore gut balance. Research indicates LGG can reduce AAD risk and supports the gut barrier. Taking LGG at least two hours away from your antibiotic dose is usually recommended.

Multi-Strain Probiotic Combinations

Combinations of strains can offer broader support. High-dose, multi-strain probiotics, including Lactobacillus and Bifidobacterium species, have shown effectiveness, especially for hospital patients. Recent studies support their use for reducing AAD risk.

Probiotic Options: A Comparison

Here’s a comparison of these top options:


Feature	Saccharomyces boulardii	Lactobacillus rhamnosus GG	Multi-Strain (e.g., L. acidophilus, Bifidobacterium lactis with S. boulardii)
Type	Yeast	Bacteria	Combination of bacteria and/or yeast
Survival	Naturally resistant to antibiotics	Hardy strain, adheres to gut lining	Varies; look for products tested for use with antibiotics
Key Benefit	Prevents AAD, effective against C. diff	AAD prevention, restores gut flora	Broader gut support, high efficacy in some settings
Timing with Antibiotics	Can be closer to antibiotic dose, but 2 hours apart is safe	Take at least 2 hours apart	Follow product instructions; some can be taken together
Best For...	Concerns about C. diff or those preferring a yeast probiotic	General AAD prevention	Comprehensive gut support, multiple symptoms

How to Heal Your Gut After Antibiotics

Continuing probiotic supplementation after finishing antibiotics is important for gut recovery. Experts often suggest continuing for two to four weeks post-antibiotic. A diet including prebiotic-rich foods (garlic, onions, oats) and fermented foods (kefir, yogurt, sauerkraut) can also help restore gut diversity. While fermented foods are beneficial for maintenance, a supplement is generally needed for therapeutic effects during antibiotic treatment.

Conclusion

For those wondering what is the best probiotic to take along with antibiotics, both Saccharomyces boulardii and Lactobacillus rhamnosus GG are strong, research-supported choices for preventing antibiotic-associated diarrhea. S. boulardii is a yeast that is not affected by antibiotics, while LGG is a well-studied bacterial strain. Starting your probiotic at the beginning of your antibiotic course and continuing for several weeks afterward is recommended to minimize side effects and support gut health. Consulting a healthcare provider can help determine the best option for your specific needs.

Visit Healthline for more detailed information on probiotics and digestive health.

Frequently Asked Questions

No, select specific, research-backed probiotic strains known to work well alongside antibiotics for best results.

Generally, take probiotics at least two hours apart from antibiotics. Some products may have specific instructions allowing them to be taken closer.

Continue taking a probiotic for at least two to four weeks after your antibiotic course to aid gut recovery.

Saccharomyces boulardii is specifically beneficial for preventing the recurrence of C. difficile.

Prioritize products containing Saccharomyces boulardii and/or Lactobacillus rhamnosus GG due to their strong evidence base.

While healthy, fermented foods typically don't provide a high enough dose of specific strains for therapeutic effects during antibiotic treatment. A supplement is usually recommended.

Probiotics are generally safe for most healthy people. However, those who are severely ill, immunocompromised, or have certain digestive conditions should consult a doctor first.