Can Fish Oil Shrink Fibroids? A Closer Look at the Evidence

October 23, 2025 •

4 min read

Up to 80% of women will develop uterine fibroids by age 50. With fibroids so common, many seek natural solutions, leading to questions like, can fish oil shrink fibroids? The science, however, suggests a more nuanced role for omega-3s, focusing on managing inflammation and hormone balance rather than directly reducing tumor size.

Quick Summary

Scientific evidence is limited on whether fish oil shrinks fibroids, but its anti-inflammatory properties and role in hormone regulation may help manage growth and symptoms, especially when combined with a balanced diet and healthy lifestyle.

Key Points

No Direct Shrinkage: Fish oil is not scientifically proven to shrink existing fibroids in humans, though it may help manage their growth.
Anti-Inflammatory Action: The omega-3 fatty acids in fish oil combat inflammation, a factor linked to fibroid growth and symptom severity.
Hormone Regulation: Omega-3s can aid in balancing hormones, particularly estrogen, which influences fibroid development.
Supportive Role: It should be used as part of a broader anti-inflammatory diet, not as a standalone cure.
Consult a Doctor: Always discuss supplement use and dietary changes with a healthcare provider, as medical treatment may be necessary.
Holistic Approach: Diet and lifestyle modifications, including managing weight and stress, provide a more comprehensive strategy for managing fibroid symptoms.

The Potential Role of Fish Oil in Fibroid Management

Fish oil, a rich source of omega-3 fatty acids, has long been recognized for its anti-inflammatory properties and broader health benefits. For those managing uterine fibroids, the potential to naturally mitigate symptoms and slow growth is a significant area of interest. However, a crucial distinction must be made: while fish oil may offer supportive benefits, the scientific community does not currently recognize it as a treatment that can directly shrink existing fibroids. Its primary function lies in addressing underlying factors, such as inflammation and hormonal imbalance, that contribute to fibroid development and progression.

Research indicates that chronic inflammation is associated with fibroid growth. Omega-3 fatty acids, particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), are potent anti-inflammatory agents that can help modulate the body's inflammatory response. By reducing this inflammation, fish oil can potentially create a less favorable environment for fibroid growth. Moreover, fibroids are known to be estrogen-sensitive tumors, meaning high estrogen levels can encourage their growth. Omega-3s play a crucial role in hormone regulation and can support the body's natural processes for balancing hormone levels.

Scientific Evidence: What the Research Shows

In vitro and Animal Studies

Laboratory and animal studies have provided some promising evidence regarding omega-3 fatty acids and fibroid cells. For example, research has shown that omega-3s can reduce proteins linked to inflammation and hormone production in fibroid cells, potentially inhibiting their growth. These controlled experiments demonstrate the plausible biological mechanisms through which omega-3s could have an effect on fibroid tissue. However, it is vital to remember that results from cell cultures and animal models do not always translate to the same outcome in humans.

Human Observational Studies

Larger human studies on the direct link between fish oil consumption and fibroid size are limited and have yielded mixed results. A prospective cohort study involving over 80,000 premenopausal women found an inverse association between total n-3 polyunsaturated fatty acids and the likelihood of developing fibroids, suggesting a potential protective effect. However, the study also emphasized the need for future confirmation. The complexities of human diets and confounding factors make it difficult to isolate the exact impact of fish oil alone. One study even controversially suggested a possible increased risk associated with omega-3s, though this finding was linked to potential environmental pollutants found in fish, underscoring the importance of high-quality sources and further investigation.

The Importance of a Holistic Dietary Approach

Focusing solely on fish oil overlooks the bigger picture of dietary influence. An anti-inflammatory diet that addresses hormonal balance is the most effective approach for managing fibroid symptoms. This involves prioritizing certain foods while limiting or avoiding others.

Here are some key dietary components to consider:

Foods rich in fiber: Whole grains, fruits, legumes, and cruciferous vegetables like broccoli and kale help balance hormones and aid in the elimination of excess estrogen from the body.
Antioxidant-rich foods: Berries, green tea (containing EGCG), and colored vegetables provide antioxidants that combat inflammation and oxidative stress.
Healthy fats: Besides fish oil, incorporating other healthy fats from sources like avocado, flaxseed, and walnuts can support hormonal health.
Liver support: The liver is crucial for detoxifying excess hormones. Foods like garlic, beets, and turmeric can help support liver function.
Vitamin D: Low levels of Vitamin D have been linked to an increased risk of fibroids. Getting sufficient amounts through sun exposure, diet (fatty fish, fortified dairy), or supplements is important.

Comparison Table: Fibroid-Friendly vs. Pro-Inflammatory Diet


Feature	Fibroid-Friendly Diet	Pro-Inflammatory Diet
Protein Sources	Fatty fish (salmon, mackerel), lean poultry, legumes, plant-based protein	Red meat, processed meats
Fats	Omega-3s from fish oil, flaxseed, avocado; monounsaturated fats	Trans fats, high-fat dairy products
Carbohydrates	Whole grains (oats, quinoa), high-fiber vegetables	Refined carbohydrates (white bread, pasta), sugary foods
Beverages	Water, green tea	Alcohol, excessive caffeine, sugary drinks
Anti-inflammatory	High intake of antioxidants (berries, green leafy vegetables)	Promotes chronic inflammation

Conclusion: Fish Oil as a Supportive Tool, Not a Cure

Ultimately, the question of can fish oil shrink fibroids is best answered with caution. There is no conclusive evidence from human studies that fish oil alone can cause existing fibroids to shrink. However, incorporating fish oil and a rich source of omega-3s into a balanced, anti-inflammatory diet is a beneficial strategy for managing fibroid symptoms and potentially slowing their growth. Lifestyle factors, including weight management, exercise, and stress reduction, also play a significant role.

It is essential to view fish oil and other dietary adjustments as supportive tools within a comprehensive management plan, not as a replacement for medical treatment. Anyone with fibroids or concerns about their symptoms should consult a healthcare provider to discuss the best course of action, which may include further investigation, medication, or minimally invasive procedures.

Frequently Asked Questions

No, diet alone cannot cure fibroids. It can, however, help manage symptoms, potentially slow growth, and support overall health when combined with proper medical treatment under a doctor's supervision.

You should limit or avoid red meat, processed foods, high-fat dairy, and refined sugar, as these can increase inflammation and potentially disrupt hormone balance, which may worsen fibroid symptoms.

Chronic inflammation is associated with fibroid development and growth. Omega-3 fatty acids, with their anti-inflammatory properties, can help modulate this response and create a less favorable environment for fibroids.

While some supplements like green tea extract (EGCG) and Vitamin D have shown promise in lab studies or small clinical trials, more robust human research is needed. No supplements are definitively proven to shrink fibroids in humans.

There is no standard dosage specifically for fibroid management. Any supplementation should be discussed with a doctor or dietitian, who can recommend a dose based on individual needs and overall health.

In addition to focusing on an anti-inflammatory diet, other natural approaches include managing stress, regular exercise, maintaining a healthy weight, and ensuring adequate Vitamin D levels.

Yes, green tea contains antioxidants like EGCG that have been studied for their anti-inflammatory effects and potential ability to slow fibroid growth and reduce symptoms.