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Do you feel sick with low B12?

4 min read

According to the National Institutes of Health, approximately 6% of adults under 60 in the USA have a vitamin B12 deficiency, with rates rising significantly in older populations. This often undiagnosed condition can manifest with a variety of symptoms that can make you feel unwell, including profound fatigue, weakness, and neurological problems.

Quick Summary

A lack of vitamin B12 can cause a person to feel unwell through a range of physical, neurological, and psychological symptoms. These manifestations stem from the vitamin's critical role in red blood cell production, DNA synthesis, and nerve function.

Key Points

  • Diverse Symptoms: A B12 deficiency can make you feel sick through a wide range of physical, neurological, and psychological symptoms, not just fatigue.

  • Anemia is the Cause: Many physical symptoms like weakness and shortness of breath are caused by megaloblastic anemia, where insufficient B12 hinders the production of healthy red blood cells.

  • Nervous System Damage: Low B12 can damage the protective myelin sheath around your nerves, leading to neurological issues such as tingling, balance problems, and cognitive decline.

  • Diagnosis is Crucial: Because symptoms can mimic other conditions, a blood test is necessary for a correct diagnosis of low B12 levels.

  • Treatment is Effective: Treatment options range from injections for severe cases to oral supplements for milder ones, and are highly effective in managing the condition and reversing symptoms.

  • Risk Factors Exist: Those at higher risk include older adults, vegans, and individuals with certain digestive conditions or who have had gastric surgery.

In This Article

Understanding Why Low B12 Makes You Feel Unwell

Vitamin B12, or cobalamin, is an essential nutrient that plays a crucial role in maintaining your health. It is vital for the production of red blood cells, which carry oxygen throughout your body. Without sufficient B12, your body can't produce enough healthy red blood cells, leading to a condition called megaloblastic anemia. This results in your tissues and organs not getting enough oxygen, causing widespread fatigue and weakness.

Additionally, B12 is fundamental for the proper functioning of your nervous system. It is involved in the synthesis of myelin, the protective sheath that covers your nerve fibers. A deficiency can cause this sheath to break down, leading to nerve damage and a host of neurological symptoms, including tingling or numbness, balance problems, and cognitive difficulties.

The Diverse Symptoms of Vitamin B12 Deficiency

Feeling unwell with a B12 deficiency can go far beyond just feeling tired. The symptoms can be physical, neurological, and psychological, and they often develop gradually over time, making them easy to overlook or misattribute to other causes.

Common physical symptoms include:

  • Persistent fatigue and weakness: Feeling unusually tired or lacking energy, which is a hallmark sign of anemia.
  • Pale or yellowish skin: Resulting from the reduced number of healthy red blood cells.
  • Digestive issues: Experiencing nausea, vomiting, diarrhea, or loss of appetite.
  • Sore, red, and swollen tongue: Also known as glossitis, this can indicate a more pronounced deficiency.
  • Weight loss: Often a consequence of loss of appetite and digestive problems.
  • Heart palpitations and shortness of breath: The body's attempt to compensate for the lack of oxygen being transported by red blood cells.

Common neurological symptoms include:

  • Numbness or tingling: A "pins and needles" sensation, particularly in the hands and feet, caused by nerve damage.
  • Difficulty walking: Leading to balance problems, stumbling, or staggering.
  • Memory loss or confusion: Often affecting short-term memory and concentration, especially in older adults.
  • Vision problems: A rare but possible symptom involving blurred or disturbed vision.

Common psychological symptoms include:

  • Irritability and mood swings: Changes in temperament or increased agitation.
  • Depression and anxiety: Low B12 levels have been linked to psychological distress.
  • More severe issues: In advanced cases, paranoia, delusions, or psychosis may occur.

Comparing Common Symptoms: Low B12 vs. Other Deficiencies

To help understand how B12 deficiency presents differently, consider how its symptoms compare to another common deficiency, like iron deficiency anemia.

Symptom Low B12 Deficiency Iron Deficiency Anemia
Fatigue Severe and persistent, a core symptom. Very common, often accompanied by weakness.
Skin Tone Pale or a yellowish, jaundiced look. Pale skin, especially under the eyelids and on the inner cheeks.
Neurological Issues Tingling, numbness, balance problems, memory loss, and mood changes are common. Neurological symptoms are rare, unlike B12 deficiency.
Tongue Painful, red, and smooth (glossitis). Swollen or sore tongue may occur, but less distinctively.
Breathing Shortness of breath, rapid heart rate. Shortness of breath, especially with exertion.
Digestion Nausea, diarrhea, and appetite loss are frequent. Constipation is more common than diarrhea.

Diagnosis and Treatment for Low B12

If you suspect you have a B12 deficiency, it is crucial to consult a healthcare provider for proper diagnosis and treatment. A doctor will typically perform a blood test to measure your serum B12 levels. In some cases, additional tests like methylmalonic acid (MMA) or homocysteine levels may be ordered to confirm the deficiency and rule out other conditions.

Treatment depends on the severity and underlying cause. For those with a severe deficiency or an absorption issue like pernicious anemia, vitamin B12 injections are often the fastest and most effective solution. These are typically administered frequently at first, then less often for maintenance. For milder deficiencies, oral high-dose supplements or nasal sprays may be sufficient. Dietary changes, including increasing intake of animal products like meat, fish, and dairy, or consuming fortified foods such as cereals and plant milks, can help manage the condition.

It is important to remember that for some, treatment may be lifelong, especially if the deficiency is caused by an underlying medical condition. Early detection and treatment are key to preventing more serious, potentially irreversible neurological damage.

Conclusion

So, can you feel sick with low B12? The answer is a definitive yes. Vitamin B12 deficiency can profoundly impact your health, causing a spectrum of physical, neurological, and psychological symptoms that can significantly diminish your quality of life. From persistent fatigue and nerve damage to mood changes and memory problems, the effects are widespread. By understanding the common signs and symptoms, and seeking prompt medical evaluation and treatment, you can effectively manage the condition and prevent long-term complications. A simple blood test is the first step toward feeling better and restoring your vitality.

Mayo Clinic - Vitamin deficiency anemia

Frequently Asked Questions

The initial signs of low B12 often include persistent, unexplained fatigue and a general feeling of being unwell. Other early symptoms can include weakness, a sore tongue, or loss of appetite.

Yes, a vitamin B12 deficiency can affect the digestive tract and cause gastrointestinal symptoms such as nausea, vomiting, and diarrhea. This is often related to the impact on rapidly-dividing cells in the gut lining.

Yes, it is possible to have a vitamin B12 deficiency and experience neurological symptoms without showing signs of anemia. Nerve damage can occur even when the blood cell count is still within a normal range.

A doctor can diagnose a B12 deficiency with a simple blood test that measures the level of vitamin B12 in your blood. In some cases, additional tests may be conducted to measure methylmalonic acid (MMA) or homocysteine levels.

For those with a severe deficiency or an absorption problem, B12 injections are the quickest way to increase levels and relieve symptoms. Oral supplements with very high doses may also be effective for milder cases.

Yes, a strict vegan or vegetarian diet is a major risk factor for B12 deficiency, as the vitamin is found naturally almost exclusively in animal products. Those on a plant-based diet should use fortified foods or supplements to prevent deficiency.

If left untreated for an extended period, a severe vitamin B12 deficiency can lead to permanent nerve damage and neurological problems. Early diagnosis and treatment are crucial to prevent this from occurring.

Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.