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Does Siberian Rhubarb Help With Weight Loss? Unpacking the Evidence

4 min read

According to a 2020 animal study published by MDPI, rhubarb supplementation effectively prevented diet-induced obesity in mice, even with increased calorie intake. While this research provides compelling evidence in animal models, the mechanisms and effectiveness in humans require closer examination.

Quick Summary

This article scrutinizes the scientific research behind Siberian rhubarb and its purported weight loss benefits, outlining how it may influence metabolism, gut microbiota, and menopause-related weight gain.

Key Points

  • Indirect Weight Management: Siberian rhubarb, especially the ERr 731 extract, may help manage weight by alleviating menopausal symptoms like poor sleep and mood swings that often lead to weight gain.

  • Hormonal Influence: The active compounds, rhaponticin and desoxyrhaponticin, exert selective estrogenic effects that can balance hormonal fluctuations during menopause.

  • Gut Microbiota Modulation: Preclinical studies indicate that rhubarb extract can foster beneficial gut bacteria, like Akkermansia muciniphila, which is linked to better metabolic health and reduced obesity.

  • Metabolic Boost: Animal research suggests rhubarb extract can increase energy expenditure and mitochondrial activity in brown adipose tissue, potentially raising the metabolic rate.

  • Increased Calorie Excretion: Evidence from mouse models shows that rhubarb supplementation can increase the excretion of calories in feces, suggesting less caloric absorption.

  • Potential Risks: Side effects can include digestive issues. Its estrogenic properties make it unsafe for people with hormone-sensitive conditions or those on hormone replacement therapy.

  • Holistic Approach: Siberian rhubarb should be considered a potential complementary aid to a healthy diet and exercise, not a standalone weight loss solution.

In This Article

What is Siberian Rhubarb?

Siberian rhubarb, known scientifically as Rheum rhaponticum, is a plant species distinct from the common garden rhubarb (Rheum rhabarbarum). While its stalks are not typically consumed as food like its culinary cousin, extracts from its roots are used in dietary supplements, most notably the standardized extract ERr 731. This extract is widely recognized for its efficacy in alleviating menopausal symptoms, such as hot flashes, irritability, and mood swings. The health benefits are attributed to its active compounds, particularly the stilbenes rhaponticin and desoxyrhaponticin, which can selectively activate certain estrogen receptors in the body.

The Link Between Siberian Rhubarb and Weight Management

Research into Siberian rhubarb's direct impact on weight loss is still developing, with much of the current evidence drawn from animal studies or indirect effects observed in human trials focused on other health issues.

Potential indirect effects on weight management include:

  • Relief of Menopausal Symptoms: Many women experience weight gain during menopause due to fluctuating hormone levels, which can lead to poor sleep, increased stress, and altered metabolism. By alleviating these symptoms, ERr 731 can indirectly support weight management efforts by improving sleep quality and reducing stress-related eating.
  • Improved Sleep Quality: Clinical studies show that the ERr 731 extract can significantly improve sleep disturbances in perimenopausal women. Restful sleep is crucial for regulating hormones that control appetite and metabolism, potentially contributing to healthier eating habits and weight control.
  • Reduced Stress: The mood-stabilizing effects of Siberian rhubarb, which reduce irritability and anxiety, can combat emotional eating, a significant barrier to weight loss for many individuals.

Scientific Mechanisms Supporting Weight Control

Beyond its effects on menopausal symptoms, broader research on rhubarb extracts points to several metabolic and physiological mechanisms that may contribute to weight control. It is important to note that many of these studies are preclinical and use extracts from different Rheum species.

  • Modulation of Gut Microbiota: Preclinical studies have shown that rhubarb extract can alter the gut microbiota composition, promoting the growth of beneficial bacteria like Akkermansia muciniphila. This microbe has been associated with improved metabolic health, reduced inflammation, and protection against diet-induced obesity.
  • Increased Energy Expenditure: Animal studies have indicated that rhubarb supplementation can increase energy expenditure and mitochondrial activity, particularly in brown adipose tissue. This suggests the potential for a higher basal metabolic rate, which helps burn more calories throughout the day.
  • Increased Fecal Energy Excretion: Evidence suggests that rhubarb extracts can lead to increased fecal energy excretion, meaning the body absorbs fewer calories from food. This was observed in mice and is considered a key mechanism for its anti-obesogenic effects in animal models.
  • Improved Adipose Tissue Metabolism: Certain compounds in rhubarb, such as anthraquinones like chrysophanol and emodin, have been shown to influence adipogenesis (fat cell formation) and regulate energy metabolism in fat cells in animal and laboratory settings.

Rhubarb vs. Siberian Rhubarb: What's the Difference for Weight Loss?

While all rhubarb species share certain properties, the specific effects and mechanisms can differ depending on the species and extract used. This comparison table highlights key distinctions relevant to weight management.

Feature Common Rhubarb (Rheum rhabarbarum) Siberian Rhubarb (Rheum rhaponticum)
Primary Culinary Use Eaten as food (stalks) Not for culinary use; roots used for medicinal extracts
Key Weight-Related Compounds High in fiber, contains sennosides (laxative effect) Standardized extracts (ERr 731) contain rhaponticin and desoxyrhaponticin
Primary Mechanism for Weight Fiber promotes satiety and digestion; laxative effect aids elimination Indirect: Relieves menopausal symptoms impacting weight; Direct (preclinical): Modulates gut microbiota, increases energy expenditure
Clinical Evidence Supports general digestive health and weight maintenance Strong evidence for menopausal symptom relief; limited direct human weight loss studies
Considerations High in oxalic acid (especially leaves); risks with excessive intake Generally safe in standardized forms; potential hormone-like effects for caution

Risks and Considerations

While Siberian rhubarb is generally safe for short-term use in standardized extract forms like ERr 731, there are important considerations and potential risks.

  • Not a Miracle Cure: Rhubarb is not a substitute for a healthy diet and regular exercise. Any potential weight loss benefits are most likely complementary to a holistic health plan.
  • Hormonal Effects: The stilbenes in Siberian rhubarb have estrogenic activity, meaning they interact with estrogen receptors. This makes it unsuitable for individuals with a history of estrogen-dependent cancers or those on hormone therapy. Consultation with a healthcare provider is essential.
  • Digestive Issues: Rhubarb contains compounds with laxative properties, which can cause stomach pain, cramps, or diarrhea, particularly with prolonged or high-dose use.
  • Kidney Health: All parts of the rhubarb plant, including the edible stalks, contain oxalic acid. Excessive intake, especially with unstandardized extracts or leaves, can increase the risk of kidney stones and may be harmful for individuals with pre-existing kidney conditions.

Conclusion

Siberian rhubarb shows promise for supporting weight management, especially in women navigating menopause, by addressing key contributing factors like sleep disturbances and stress. Preclinical studies also suggest potential direct benefits on metabolism and gut health. However, the evidence for direct, significant weight loss in humans is currently limited, and it should be viewed as a complementary aid rather than a primary solution. Given its hormonal activity and potential for side effects, consulting a healthcare professional before starting any supplement is crucial.

Optional Outbound Link: For a deeper dive into the metabolic pathways affected by rhubarb-derived substances, see this review on the National Institutes of Health website: A Review on Rhubarb-Derived Substances as Modulators of Metabolic Syndrome

Frequently Asked Questions

Siberian rhubarb, in the form of the ERr 731 extract, helps by relieving symptoms like hot flashes, sleep disturbances, and mood swings that often contribute to weight gain during menopause. By improving these factors, it supports healthier eating habits and better metabolic function.

No, it is not considered a direct weight loss supplement. While preclinical studies suggest metabolic benefits, human studies primarily show its effectiveness for menopausal symptom relief, which can indirectly aid weight management.

Common rhubarb (Rheum rhabarbarum) is a culinary vegetable known for its fiber and mild laxative effect. Siberian rhubarb (Rheum rhaponticum) is used for medicinal extracts from its root, specifically for its estrogenic compounds that treat menopausal symptoms.

While common rhubarb stalks are low in calories and high in fiber, making them a healthy dietary choice, they do not offer the specific metabolic effects seen with concentrated Siberian rhubarb root extracts. The leaves are poisonous due to high oxalic acid content and should never be consumed.

Side effects can include digestive issues like stomach pain or diarrhea. Its hormonal activity also means it should be avoided by individuals with estrogen-dependent cancers or those on hormone therapy.

Preclinical studies show that rhubarb extract can positively remodel the gut microbiota, increasing beneficial bacteria like Akkermansia muciniphila. This microbe is associated with improved metabolism and reduced obesity.

Siberian rhubarb is not recommended for pregnant or breastfeeding women, individuals with hormone-sensitive cancers, or people with certain gastrointestinal issues or kidney disease.

Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.