Does Walmart Carry Methylfolate Supplements?

January 10, 2026 •

4 min read

According to Walmart's website, a quick search for 'methylfolate' reveals numerous products from various brands available for purchase, confirming that Walmart does carry methylfolate. This is great news for shoppers seeking the highly bioavailable, active form of folate, especially those who prefer the convenience of in-store or online shopping from a major retailer.

Quick Summary

Walmart offers a wide selection of methylfolate supplements, both in-store and online, featuring brands like Now Foods, Nutricost, and Life Extension. These products cater to individuals needing the active form of vitamin B9, including those with genetic variations affecting folate metabolism, like the MTHFR mutation.

Key Points

Walmart stocks methylfolate: The retailer offers a variety of methylfolate supplements, also known as L-Methylfolate or 5-MTHF, from different brands both online and in stores.
Active form of folate: Methylfolate is the biologically active form of vitamin B9 that the body can use directly, unlike synthetic folic acid.
Bypasses MTHFR gene issues: It is particularly beneficial for individuals with MTHFR genetic mutations who have difficulty converting folic acid to its active form.
Diverse brands available: Brands like Now Foods, Nutricost, and Life Extension are frequently available at Walmart, providing customers with several options.
Supports vital functions: Methylfolate is crucial for producing neurotransmitters, maintaining heart health by regulating homocysteine levels, and aiding in red blood cell formation.
Consider B12 levels: It is important to ensure adequate Vitamin B12 levels when taking methylfolate, as high folate intake can mask a B12 deficiency.

Methylfolate Availability at Walmart

Walmart has become a prominent marketplace for health and wellness products, including a robust selection of vitamins and supplements. A search on their website or a visit to the vitamin aisle will confirm that Walmart does indeed carry methylfolate, often labeled as L-Methylfolate or 5-MTHF. The availability includes a range of potencies and formulations, from capsules and tablets to dissolvable lozenges, catering to different consumer needs. This widespread availability is a significant benefit for individuals who need the pre-converted form of folate, bypassing potential metabolic issues associated with the MTHFR gene.

Popular Methylfolate Brands at Walmart

When shopping for methylfolate at Walmart, customers will find several trusted brands. This variety allows for comparison shopping based on dosage, price, and other ingredients. Some popular options include:

Now Foods Methyl Folate: Often available in a 1,000 mcg dosage, this product is well-known for its superior bioavailability and use of the patented Quatrefolic form.
Nutricost Methyl Folate: Nutricost offers methylfolate in various potencies, including high-dose 15mg capsules, and labels their products as Non-GMO and gluten-free.
Life Extension Optimized Folate: This option provides a standardized dose and is formulated for heart and brain support, emphasizing its vegetarian and gluten-free status.
Seeking Health: This brand, often listed on Walmart's online marketplace, provides targeted support for individuals with MTHFR gene variations, offering L-5-MTHF supplements.

Why Choose Methylfolate Over Folic Acid?

While folic acid is a synthetic form of Vitamin B9 found in many fortified foods, methylfolate is the active, natural form that the body can use immediately. This distinction is critical for many people. Folic acid requires conversion by the MTHFR enzyme to become active. For the significant portion of the population with a genetic MTHFR mutation, this conversion process is inefficient. As a result, unconverted folic acid can build up in the body, which can be problematic, while the body remains deficient in the active form of folate. Choosing methylfolate bypasses this issue entirely.

Benefits of supplementing with methylfolate include:

Enhanced Bioavailability: Because it is already in the active form, it is more readily absorbed and used by the body, ensuring more efficient supplementation.
Support for Genetic Variations: It is particularly beneficial for those with MTHFR genetic mutations who struggle to convert synthetic folic acid.
Boosted Neurotransmitter Production: As it can cross the blood-brain barrier, it helps facilitate the production of key neurotransmitters like serotonin and dopamine, supporting cognitive function and mood.
Healthy Homocysteine Levels: By assisting in the conversion of homocysteine to methionine, it helps maintain cardiovascular health.

Shopping for Methylfolate at Walmart: Online vs. In-store

Walmart offers shoppers two main avenues for purchasing methylfolate: online through Walmart.com and in physical stores. Both have their advantages and disadvantages.

In-store Shopping: A primary benefit is the immediate gratification of finding and purchasing a product on the same day. However, in-store selection can be limited, depending on the specific location and inventory. Customers also have the opportunity to physically inspect the product and its packaging.
Online Shopping: The online platform, Walmart.com, provides a significantly broader selection of brands and dosages, including marketplace sellers. While offering more choice and convenience, it requires waiting for shipping, and customers rely on product images and descriptions for information.

It is recommended to check Walmart.com first to see the full range of options, including customer ratings and reviews, before heading to a physical store or placing an order.

Methylfolate and Other B Vitamins

Methylfolate is part of the B-complex family, and its efficacy is closely linked to other B vitamins, especially Vitamin B12. Many supplement manufacturers recognize this synergistic relationship and offer combination products. For example, some formulations at Walmart include methylfolate with methylcobalamin (the active form of B12) to ensure balanced methylation support. It's important to have adequate Vitamin B12 levels when supplementing with methylfolate, as high folate intake can mask a B12 deficiency.

Comparison Table: Methylfolate vs. Folic Acid


Feature	Methylfolate	Folic Acid
Form	Active, natural form (5-MTHF)	Inactive, synthetic form
Absorption	Directly usable by the body; high bioavailability	Requires multi-step enzymatic conversion
MTHFR Benefit	Bypasses genetic conversion limitations	Ineffective conversion for those with MTHFR mutations
Source	Found in leafy greens, eggs, legumes; available as supplement	Synthetic, used in fortified foods and many supplements
Cost	Generally more expensive due to processing	Less expensive and widely available
Potential Issues	May mask B12 deficiency if not monitored	Potential buildup of unconverted folate

Conclusion

In summary, Walmart does carry methylfolate, offering a diverse selection of brands and dosages for online and in-store shoppers. The availability of this active form of folate is especially valuable for the significant portion of the population with MTHFR gene variations who cannot properly metabolize synthetic folic acid. Choosing methylfolate provides a more bioavailable option for essential bodily functions, including mood regulation, red blood cell production, and heart health. Always consult with a healthcare professional before starting any new supplement regimen, particularly to determine the appropriate dosage and to ensure your overall B vitamin levels are balanced. For those with MTHFR concerns, shopping at Walmart and selecting a reputable methylfolate product is a convenient and accessible solution. You can begin your search on the Walmart health and wellness website.

Frequently Asked Questions

Yes, many Walmart stores carry methylfolate supplements in the health and wellness or vitamin aisle. However, the in-store selection may be more limited than the online offerings. It's best to check your local store's inventory on Walmart.com beforehand.

Walmart carries products from well-known supplement brands such as Now Foods and Nutricost, many of which use high-quality, patented forms of methylfolate like Quatrefolic. As with any supplement, check the brand reputation and customer reviews on the Walmart website to make an informed choice.

Methylfolate is the active, readily absorbed form of folate, while folic acid is a synthetic form that requires the body to convert it before use. For those with MTHFR gene variations, methylfolate is a more effective option as it bypasses this conversion process entirely.

Walmart stocks several brands, including Now Foods, Nutricost, Life Extension, and Carlyle, among others available through its online marketplace. You can find these by searching 'methylfolate' on Walmart's website.

Yes, it is highly recommended to consult a healthcare provider before taking any new supplement, including methylfolate. A doctor can help determine if it's the right supplement for you, especially if you have an MTHFR gene mutation, and can advise on the proper dosage.

Yes, for individuals with an MTHFR gene mutation, methylfolate is an excellent choice. It provides the active form of folate that can be used directly by the body, overcoming the impaired conversion process of synthetic folic acid.

Yes, Walmart's online store, Walmart.com, offers a wide range of methylfolate products for purchase with home delivery. Many products are also available for in-store pickup.