Skip to content

How Does Olive Oil Affect Inflammation in the Body?

3 min read

According to a 2023 study published in the journal Nutrients, high-phenolic extra virgin olive oil consumption was linked to significantly lower inflammatory markers in individuals with rheumatoid arthritis. This powerhouse of the Mediterranean diet, especially extra virgin olive oil, can positively affect inflammation within the body through its rich composition of healthy fats and potent antioxidants.

Quick Summary

Extra virgin olive oil's rich content of monounsaturated fats and powerful polyphenols like oleocanthal actively combat chronic inflammation. Research highlights its ability to reduce inflammatory markers and protect against conditions driven by inflammation.

Key Points

  • Oleocanthal Acts Like Ibuprofen: Extra virgin olive oil contains oleocanthal, a compound with potent anti-inflammatory properties similar to a nonsteroidal anti-inflammatory drug (NSAID).

  • Rich in Antioxidant Polyphenols: EVOO is loaded with antioxidants, such as hydroxytyrosol, which combat oxidative stress and help prevent inflammation.

  • Reduces Inflammatory Markers: Consumption of olive oil has been shown to lower levels of inflammatory markers like C-reactive protein (CRP) and certain pro-inflammatory cytokines.

  • Superior to Refined Oils: Unlike heavily processed refined oils high in omega-6s, high-phenolic extra virgin olive oil actively reduces inflammation and protects against related diseases.

  • A Staple of the Mediterranean Diet: The anti-inflammatory effects of olive oil are a key reason for the health benefits observed in Mediterranean populations, including reduced risk of heart disease.

  • Maximize Benefits with High-Phenolic EVOO: For the greatest anti-inflammatory effect, choose a high-quality, early-harvest extra virgin olive oil, and use it uncooked or for low-heat cooking.

In This Article

Chronic, low-grade inflammation is a significant driver of many diseases, including heart disease, cancer, type 2 diabetes, arthritis, and Alzheimer's. Understanding how to mitigate this silent threat through diet is critical for long-term health. Olive oil, particularly extra virgin olive oil (EVOO), is celebrated for its potent anti-inflammatory effects. Its health benefits are primarily attributed to its unique nutritional composition, which works to modulate inflammatory pathways and reduce systemic inflammation.

The Anti-Inflammatory Powerhouse in Extra Virgin Olive Oil

Not all olive oils are created equal when it comes to combating inflammation. The highest-quality product, EVOO, retains the most beneficial compounds because it is produced through a cold-pressing process that avoids high heat and chemical solvents. Less-refined versions, like regular or light olive oil, lose many of these beneficial properties during processing.

Key Anti-Inflammatory Compounds

  • Oleocanthal: This compound acts similarly to ibuprofen by inhibiting enzymes responsible for producing inflammatory molecules. Research suggests it can be more potent than ibuprofen at inhibiting COX activity in vitro.
  • Polyphenols: EVOO is rich in antioxidants like hydroxytyrosol and tyrosol. These protect cells from oxidative stress, which can trigger inflammation.
  • Oleic Acid: The main monounsaturated fatty acid in olive oil, oleic acid can also help reduce inflammation by lowering inflammatory markers like C-reactive protein (CRP).

Mechanisms of Action

EVOO's anti-inflammatory effects involve several biological processes:

  • Reduction of Pro-Inflammatory Cytokines: Compounds like hydroxytyrosol help decrease signaling molecules such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α).
  • Enhancement of Antioxidant Pathways: EVOO can boost the body's natural antioxidant defenses, protecting cells and counteracting oxidative stress.
  • Modulation of Epigenetics: Components of EVOO may influence epigenetic pathways linked to chronic inflammation, suggesting a long-term impact.

Olive Oil vs. Other Cooking Oils: A Comparison

The choice of cooking oil significantly impacts inflammation. Refined oils high in omega-6 fatty acids can contribute to inflammation.

Feature Extra Virgin Olive Oil (EVOO) Refined Seed Oils (e.g., Sunflower, Canola)
Processing Cold-pressed, minimal processing. High heat and chemical extraction.
Nutrient Content High in polyphenols, antioxidants, and vitamins E and K. Stripped of most nutrients during processing.
Fatty Acid Profile Rich in anti-inflammatory monounsaturated fats (oleic acid). High in pro-inflammatory omega-6 fatty acids.
Inflammatory Effects Reduces inflammation via oleocanthal and polyphenols. Can promote inflammation and oxidative stress.
Recommended Use Best for dressing, drizzling, or low-to-moderate heat cooking. Suitable for high-heat cooking but less nutritious.

Practical Ways to Incorporate Olive Oil

Adding olive oil to your diet is easy. Use high-phenolic EVOO and avoid overheating it.

Tips for Daily Consumption

  • As a Finishing Oil: Drizzle EVOO over cooked dishes.
  • In Dressings: Use EVOO for homemade salad dressings.
  • For Low-Heat Sautéing: Use EVOO for cooking over low-to-medium heat.
  • With Other Anti-Inflammatory Foods: Pair EVOO with leafy greens, fatty fish, nuts, and berries for synergistic effects.

Conclusion

Scientific evidence strongly supports the anti-inflammatory properties of extra virgin olive oil due to its polyphenols, oleic acid, and oleocanthal. Regular consumption as part of a Mediterranean-style diet can reduce chronic inflammation and disease risk. Choose high-phenolic EVOO and use it uncooked or lightly heated for maximum benefit. A tablespoon or two daily is a simple step towards better health.

Frequently Asked Questions

High-phenolic extra virgin olive oil (EVOO) is the best choice for fighting inflammation. It is cold-pressed and minimally processed, preserving a high concentration of beneficial polyphenols and antioxidants.

While recommendations vary, many studies suggest that consuming one to two tablespoons (15-30ml) of high-phenolic EVOO per day can provide significant anti-inflammatory benefits.

Yes, but for maximum anti-inflammatory benefits, use EVOO for low-to-moderate heat cooking or as a finishing oil. High heat can degrade some of the polyphenols and antioxidants.

When consumed as part of a balanced diet, olive oil has no known negative side effects related to inflammation. It is important to note that it is calorie-dense and should be consumed in moderation as part of a healthy lifestyle.

Oleocanthal in EVOO inhibits the same inflammatory enzymes (COX-1 and COX-2) as ibuprofen. At equimolar concentrations, oleocanthal has been shown to be even more potent in laboratory settings, though this does not replace medical treatment.

Studies have shown promising results, with olive oil consumption linked to lower inflammatory markers and disease severity in people with rheumatoid arthritis. However, it is a complementary approach and not a cure.

Extra virgin olive oil is less processed and retains a higher concentration of beneficial polyphenols and antioxidants. Regular olive oil is more refined, resulting in fewer nutrients and weaker anti-inflammatory properties.

References

  1. 1
  2. 2
  3. 3

Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.