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What are the side effects of Erythorbate?

4 min read

The FDA classifies erythorbate as 'Generally Recognized as Safe' (GRAS) for most consumers. However, individuals with specific sensitivities or pre-existing conditions may experience adverse effects, making understanding the potential side effects of Erythorbate important for informed food choices.

Quick Summary

Erythorbate is a food additive generally considered safe, but sensitive individuals may experience headaches, fatigue, or allergic reactions. Risks for gout or kidney stones exist with high consumption.

Key Points

  • Generally Safe: Erythorbate is generally recognized as safe (GRAS) by the FDA for most consumers when used within approved levels.

  • Sensitive Reactions: Individuals with sensitivities may experience mild side effects like headaches, dizziness, fatigue, and body flushing.

  • Pre-existing Risks: Those with a history of gout or kidney stones face a higher risk of triggering symptoms or formation due to excess intake.

  • No Nutritional Value: Unlike its isomer Vitamin C (ascorbic acid), erythorbate offers no nutritional benefits.

  • Prevents Nitrosamines: Erythorbate plays a vital role in preventing the formation of carcinogenic nitrosamines in cured meats.

  • Hemolysis Risk: In very rare and sensitive cases, it has been linked to hemolysis, the premature destruction of red blood cells.

In This Article

What is Erythorbate?

Erythorbate is an antioxidant food additive, most commonly used in its sodium salt form, sodium erythorbate (E316). Chemically, it is a stereoisomer of ascorbic acid, which is more famously known as Vitamin C. While erythorbate has similar antioxidant properties to Vitamin C, it provides no nutritional vitamin content. It is manufactured by fermenting food-grade starch. In the food industry, it serves several key functions, primarily acting as a preservative to prevent oxidation.

Its key uses include:

  • Meat Processing: Speeds up the curing process in meats like hot dogs and bacon, helping to retain their pink color and prevent the formation of carcinogenic nitrosamines.
  • Beverages: Used in soft drinks and juices to prevent browning and preserve flavor.
  • Canned Foods: Added to fruits and vegetables to maintain their color and freshness during storage.
  • Snacks and Baked Goods: Prevents rancidity and spoilage.

Official Safety Status and General Tolerance

For the majority of the population, erythorbate is not associated with significant side effects. The U.S. Food and Drug Administration (FDA) has designated sodium erythorbate as 'Generally Recognized as Safe' (GRAS). Similarly, the European Food Safety Authority (EFSA) re-evaluated erythorbic acid (E315) and sodium erythorbate (E316) and concluded that they are not a safety concern when used within permitted levels. Studies reviewed by EFSA found low acute toxicity and no genotoxicity or carcinogenicity concerns from standard exposure.

Potential Side Effects in Sensitive Individuals

While generally safe, some people who are sensitive to sodium erythorbate may experience adverse reactions. These symptoms are typically mild and not life-threatening, but can cause discomfort. Short-term side effects include:

  • Headaches
  • Dizziness
  • Fatigue or lethargy
  • Body flushing, which is a sensation of warmth and redness in the skin
  • Gastrointestinal distress, like upset stomach or diarrhea

Risks for Individuals with Pre-existing Conditions

For individuals with a history of certain health issues, the consumption of erythorbate can pose a higher risk. Long-term, excess intake may exacerbate these conditions.

  • Gout: People with a history of gout, a form of arthritis caused by high uric acid levels, should be cautious. Erythorbate can potentially trigger gout symptoms.
  • Kidney Stones: In sensitive individuals, high or regular consumption of erythorbate can lead to the buildup of acidic substances, increasing the risk of forming kidney stones. Drinking plenty of water is advised to dilute these substances.
  • Hemolytic Anemia: In rare cases, sodium erythorbate has been linked to hemolysis, the premature destruction of red blood cells. This can lead to hemolytic anemia, a condition where the body cannot produce new red blood cells quickly enough to replace the destroyed ones.

Comparison: Erythorbate vs. Ascorbic Acid

Erythorbate is often used as a more cost-effective alternative to ascorbic acid in food processing. Here is a comparison of their key attributes:

Feature Erythorbate (Sodium Erythorbate) Ascorbic Acid (Vitamin C)
Antioxidant Effect Potent antioxidant effect, often comparable to ascorbic acid in preserving color and flavor. Potent antioxidant effect; acts synergistically with other antioxidants like Vitamin E.
Nutritional Value No nutritional vitamin content. Is Vitamin C, an essential nutrient for the human body.
Use in Foods Primarily used as an additive to improve stability and appearance in processed foods. Can be used as a food additive, but also a nutritional supplement.
Cost Generally less expensive to produce and purchase for food processing. Typically more expensive due to its nutritional value.
Sensitivity Risk Small percentage of sensitive individuals may experience adverse reactions. Less likely to cause sensitivity reactions, though possible at high supplemental doses.

How to Manage Erythorbate Intake

If you believe you are sensitive to erythorbate or have a pre-existing condition, managing your intake involves being mindful of food labels. Erythorbate, or sodium erythorbate, will be listed in the ingredients list of processed foods. Since it is commonly used in cured meats, this is a good place to start monitoring your consumption. For those with a history of gout or kidney stones, a consultation with a healthcare provider is recommended.

Conclusion

While erythorbate is a safe and effective food additive for most people, it is not without potential issues for sensitive individuals. For those prone to allergic reactions, headaches, or flushing, or with a history of gout or kidney stones, moderating consumption is a wise approach. As always, listening to your body and consulting with a doctor if you suspect an adverse reaction is the best course of action. For more information, you can review the extensive safety data available from institutions like the European Food Safety Authority (EFSA).

Safety during pregnancy and breastfeeding

Some sources note that the safety of erythorbate has not been extensively studied in pregnant or breastfeeding women. While not conclusively proven as harmful, it's prudent to consult with a doctor before significant consumption during these periods.

Addressing concerns about cancer

Erythorbate is known to inhibit the formation of carcinogenic nitrosamines in cured meats, and expert panels have found no evidence linking its use as an additive to cancer. Early studies in rats also did not show carcinogenic effects. While high doses in animal studies were noted, the amount consumed by humans is significantly lower.

What if you're not sensitive?

For the vast majority of consumers who do not have a known sensitivity, erythorbate poses no significant health risk at the concentrations typically found in food. It serves a crucial purpose in extending the shelf-life and safety of many common products.

[EFSA Link: https://www.efsa.europa.eu/en/efsajournal/pub/4360]

Frequently Asked Questions

For most people, erythorbate is not considered bad and is recognized as safe by regulatory bodies like the FDA. Adverse effects are typically limited to sensitive individuals or those consuming excessive amounts.

Erythorbate is a stereoisomer of ascorbic acid (Vitamin C) but lacks any nutritional vitamin value. While both function as antioxidants, ascorbic acid is an essential nutrient, whereas erythorbate is primarily a food preservative.

Yes, for individuals who are sensitive to erythorbate, headaches and dizziness have been reported as potential side effects.

People with a history of gout, kidney stones, or known sensitivities should be cautious. It is also advised to consult a doctor, especially for pregnant or breastfeeding women, as its safety in these populations is not extensively studied.

Excess consumption of erythorbate can lead to a buildup of acidic substances in sensitive individuals, which may increase the risk of kidney stone formation.

Some sources have explored potential links to histamine intolerance, but studies reviewed by regulatory bodies have not found a significant link between erythorbate and increased histamine levels.

Yes, for individuals with a pre-existing history of gout, excess erythorbate consumption has been noted as a potential trigger for gout symptoms.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.