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What are the Side Effects of VLCD? Understanding the Risks

5 min read

According to research, very low-calorie diets (VLCDs), defined as consuming 800 calories or less daily, can lead to rapid weight loss in the short term, but also carry significant risks. Understanding what are the side effects of VLCD is critical before starting any such program.

Quick Summary

This article details the common and severe side effects associated with very low-calorie diets (VLCDs), including short-term issues like fatigue and potential long-term risks such as gallstones. It also discusses the importance of medical supervision and strategies for managing the dietary challenges and preventing weight regain.

Key Points

  • Common Short-Term Side Effects: Expect fatigue, headaches, dizziness, constipation or diarrhea, and feeling cold in the first few weeks due to the body adjusting to severe calorie restriction.

  • Risk of Gallstones: Rapid weight loss from a VLCD significantly increases the risk of developing gallstones, a painful and serious complication.

  • Muscle Mass Loss: Despite being high in protein, VLCDs can lead to a reduction in lean muscle mass, which slows metabolism and increases the risk of weight regain.

  • Danger of Nutrient Deficiencies: Without proper, medically formulated supplements, a VLCD can cause critical deficiencies in vitamins and minerals, leading to severe health complications.

  • Importance of Medical Supervision: A VLCD should only be undertaken under strict medical supervision to manage side effects, prevent complications, and ensure nutritional completeness.

  • Psychological Challenges: The restrictive nature of the diet can cause irritability, mood swings, and potential social isolation due to food-related anxieties.

  • High Risk of Weight Regain: VLCDs carry a high risk of weight regain after the diet period ends, especially without a well-managed transition and long-term plan.

In This Article

Short-Term Side Effects of a VLCD

During the initial phase of a very low-calorie diet, which typically lasts from four to sixteen weeks, the body undergoes a significant adjustment period. The drastic reduction in calorie intake triggers several physiological responses as the body shifts from burning carbohydrates for energy to utilizing stored fat, a process known as ketosis. While this metabolic state is crucial for rapid weight loss, it also causes a range of mild to moderate side effects.

Some of the most common short-term effects include:

  • Fatigue and Low Energy: With significantly less fuel from food, it is common to experience persistent tiredness, lethargy, and a general lack of energy. This often improves as the body adapts to ketosis.
  • Headaches and Dizziness: Headaches and lightheadedness can occur, particularly in the first few weeks, as a result of dehydration and electrolyte imbalances. Staying well-hydrated is essential to mitigate these symptoms.
  • Nausea and Diarrhea/Constipation: Digestive issues are frequent, with some individuals experiencing nausea and others struggling with either diarrhea or constipation. The lack of dietary fiber in many meal replacement formulas contributes to constipation.
  • Feeling Cold: The body's metabolic rate slows down in response to severe calorie restriction, leading to a sensation of being constantly cold.
  • Bad Breath (Halitosis): The process of fat burning produces ketones, which are released through the breath and can cause an unpleasant, fruity odor.

These minor symptoms are typically temporary and often resolve as the body adjusts, especially when the diet is properly supervised. However, their presence highlights the physiological stress placed on the body by a VLCD.

Serious Medical Risks and Complications

While the short-term side effects can be managed, VLCDs pose more serious health risks, particularly when not medically supervised or when used for extended periods. These complications underscore why such diets are only recommended for specific individuals under strict medical care.

Gallstone Formation

Rapid weight loss is a well-documented risk factor for the development of gallstones (cholelithiasis). When a person loses weight very quickly, the liver secretes extra cholesterol into the bile. This, combined with less frequent gallbladder contractions due to the absence of dietary fat, can cause cholesterol crystals to form and accumulate. In some cases, gallstones can lead to pain and inflammation, requiring medical intervention.

Nutrient Deficiencies

Without proper medical guidance and supplementation, a severe calorie deficit can lead to critical vitamin and mineral deficiencies. Unmonitored VLCDs that lack balanced nutritional content can cause serious health problems, including cardiac arrhythmias and sudden death. Modern, medically supervised VLCDs use formulated meal replacements to ensure adequate intake of essential vitamins, minerals, and electrolytes.

Loss of Muscle Mass

Although VLCDs are designed to preserve lean muscle mass by providing a high protein intake, some muscle loss is often inevitable, especially with prolonged use or insufficient protein consumption. A reduction in lean body mass can lead to a slower metabolism, which contributes to the high rate of weight regain after the diet is stopped.

Electrolyte Imbalances and Cardiac Issues

Unsupervised VLCDs, particularly those based on early, poorly formulated liquid protein diets, have been linked to dangerous electrolyte imbalances and cardiac complications. These severe issues highlight the critical importance of regular medical monitoring, including blood tests, throughout the duration of the diet.

Psychological and Social Impacts

Beyond the physical side effects, the restrictive nature of a VLCD can have significant psychological and social consequences. The mental challenges include:

  • Irritability and Mood Swings: The stress of severe calorie restriction and hormonal changes can impact mood, leading to increased irritability.
  • Increased Hunger and Obsession with Food: Despite initial studies suggesting reduced cravings, the body's hunger hormones, like ghrelin, can be thrown off balance, leading to persistent hunger and preoccupation with food.
  • Social Isolation: The highly restrictive nature of the diet makes social situations centered around food, such as restaurant dinners or family gatherings, extremely difficult to navigate, potentially leading to social withdrawal.

VLCD vs. Low-Calorie Diet (LCD): A Comparison

Feature Very Low-Calorie Diet (VLCD) Low-Calorie Diet (LCD)
Calorie Intake ≤ 800 kcal/day ~1,000-1,500 kcal/day
Pace of Weight Loss Very rapid (1.5-2.5 kg/week) Gradual (0.5-1 kg/week)
Medical Supervision Strongly required due to health risks Recommended, but less intensive
Risk of Side Effects Higher risk, including gallstones Lower risk; milder side effects
Sustainability Short-term solution (max 12-16 weeks) More sustainable for long-term habits
Risk of Weight Regain High, especially without post-diet plan Lower, easier to build sustainable habits
Typical User Moderately to severely obese patients Most individuals seeking weight loss

Strategies for Mitigating VLCD Side Effects

To minimize the risks and manage the side effects of a VLCD, it is imperative to follow a medically supervised program. A healthcare professional can tailor the diet, monitor your progress, and manage complications. Key strategies include:

  1. Nutritionally Complete Formulas: Using modern, professionally formulated meal replacements ensures the body receives essential vitamins, minerals, and protein, preventing deficiencies.
  2. Adequate Hydration: Drinking plenty of water is crucial for flushing out ketones, preventing dehydration, and alleviating headaches and dizziness.
  3. Resistance Training: Combining the diet with resistance exercise can help preserve lean muscle mass, especially when coupled with adequate protein intake.
  4. Careful Transition: A structured transition back to conventional foods is necessary to prevent rapid weight regain and further metabolic issues.
  5. Behavioral Support: Ongoing psychological support can help manage the mental and emotional stress associated with such a restrictive diet, improving long-term adherence and success.

For more detailed guidance on dietary management and safety, the Irish Nutrition and Dietetic Institute offers valuable resources.

Conclusion

While a very low-calorie diet can deliver significant and rapid weight loss, it is not a solution for everyone and comes with a host of potential side effects and health risks. Common issues like fatigue, headaches, and digestive problems are frequent, but more serious complications, including gallstones, nutrient deficiencies, and muscle loss, can occur without proper medical supervision. The psychological toll and high risk of weight regain also make VLCDs a challenging long-term strategy. For those considering this path, thorough medical evaluation, professional guidance, and a comprehensive plan for post-diet weight management are non-negotiable steps to ensure safety and increase the likelihood of lasting success. Ultimately, a balanced, sustainable approach to weight loss is often the safer and more effective option for most individuals.

Frequently Asked Questions

No, a VLCD is not safe for everyone. It is generally reserved for individuals with moderate to severe obesity and should not be used by pregnant or breastfeeding women, children, adolescents, or older adults unless under strict medical supervision. Individuals with certain medical conditions, like Type 1 diabetes or severe heart or kidney disease, should also avoid them.

A VLCD is a very low-calorie diet of 800 calories or less per day, typically using meal replacements for rapid weight loss. An LCD is a low-calorie diet of 1,000–1,500 calories, offering more gradual weight loss and allowing for more conventional foods.

Fatigue and headaches are common early side effects because the body is adjusting to a significant calorie deficit and shifting its energy source. Dehydration and temporary electrolyte imbalances contribute to these symptoms, which often improve as the body adapts.

The risk of gallstone formation is a serious consideration during a VLCD. Medical supervision is key, and healthcare providers may sometimes prescribe medication, such as ursodiol, or adjust the diet to ensure proper gallbladder function.

While VLCDs are effective for rapid short-term weight loss, they are often no more effective than standard low-calorie diets for long-term maintenance. The high rate of weight regain is a major challenge, emphasizing the need for a comprehensive, post-diet plan.

Signs of a serious complication include persistent, severe headaches; extreme dizziness or fainting; severe abdominal pain (especially in the upper right side); irregular heartbeat; and significant dehydration. These symptoms require immediate medical attention.

VLCDs can cause a metabolic slowdown as the body enters 'starvation mode' to conserve energy. This, combined with potential muscle mass loss, makes it harder to lose weight and easier to regain it once the diet is over.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.