Finding the Best NAD+ Supplement: What brand of NAD+ is the best?

By age 40, NAD+ levels have declined by as much as 50%, leading to age-related issues like fatigue and slower metabolism. Finding the right supplement to address this decline starts with asking: What brand of NAD+ is the best for my individual needs?

Quick Summary

Comparing NAD+ supplements involves evaluating key factors like precursor type (NMN or NR), purity, testing, and delivery method to select the most effective option for cellular health.

Key Points

• Precursor Type: Consider whether NMN (more direct metabolic step to NAD+) or NR (well-researched, with patented forms available like Tru Niagen) better suits your preference.

• Purity and Testing: Due to less stringent regulation in the supplement industry, verifying high purity and third-party lab testing (e.g., from NSF or USP) is critical to confirm product quality and accuracy.

• Delivery Method: Beyond standard capsules, explore options like sublingual powders (such as from ProHealth) or liposomal liquids, which are designed with specific absorption goals in mind.

• Supporting Ingredients: Many leading brands, including Wonderfeel and Omre, incorporate additional nutrients like antioxidants (such as Resveratrol) or methyl donors (like TMG), intended to enhance effectiveness and support NAD+ pathways.

• Align with Goals: Brands cater to different needs; Wonderfeel offers a comprehensive formula, Tru Niagen focuses on clinically supported NR, and ProHealth targets users seeking high purity and specific preparation methods. Consider your personal health objectives when making a selection.

Understanding NAD+ and its Precursors

Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme present in every living cell, crucial for energy production, DNA repair, and cellular defense. As we age, our natural NAD+ levels decrease, contributing to many signs of aging. Since the NAD+ molecule is too large for efficient oral absorption, supplements focus on providing precursors, primarily Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR).

NMN vs. NR: The Key Differences

Both NMN and NR are utilized by the body to raise NAD+ levels, but they involve slightly different metabolic steps:

• NMN is a direct precursor to NAD+, requiring fewer conversion steps than NR. Research indicates the presence of a specific transporter in the small intestine that facilitates NMN delivery into cells, potentially offering an efficient way to boost NAD+ levels.
• NR is also a form of Vitamin B3 and serves as a well-researched precursor. It is typically converted into NMN within the body before being used to produce NAD+. Patented forms of NR, such as Niagen found in Tru Niagen, are supported by clinical studies.

Factors to Consider When Choosing a NAD+ Brand

When evaluating which brand of NAD+ is the best for you, focus on a few key criteria:

• Purity and Third-Party Testing: Due to the supplement industry's varying regulatory landscape, ensuring high-purity ingredients and verification by independent third-party testing (from organizations like NSF, USP, or other ISO-accredited laboratories) is essential to confirm the product's contents match its label.
• Delivery Method: While capsules are a common and effective way to take supplements, some brands employ alternative delivery systems aimed at improving absorption efficiency. These may include:
  • Liposomal Liquids or Gels: These formulations encapsulate the active ingredients within lipid structures designed to protect them from stomach acid and potentially enhance bioavailability.
  • Sublingual Powders or Tablets: Designed to dissolve under the tongue, allowing for direct absorption into the bloodstream.
• Supporting Ingredients: Some brands formulate their NAD+ precursors with other compounds believed to work synergistically, such as antioxidants (like Resveratrol or Pterostilbene) or methyl donors (such as TMG), which may support cellular processes related to NAD+ function.
• Brand Reputation and Research: Selecting brands known for transparency regarding their ingredient sourcing and manufacturing processes is important. Prioritizing brands that base their formulations on scientific research rather than solely on marketing claims is also a good practice.

Leading Brands of NAD+ Supplements

Wonderfeel Youngr NMN

Recognized as a leading option, Wonderfeel Youngr NMN utilizes a multi-targeted approach. The formula includes a form of NMN along with antioxidants such as Resveratrol and Olive Fruit Extract. This combination is designed to support NAD+ levels and help counteract their decline. The brand emphasizes rigorous quality control and clear labeling. Some individuals have reported experiencing increased energy levels and improved sleep patterns with its use.

Tru Niagen

A prominent brand in the NR supplement category, Tru Niagen is supported by extensive human studies examining its safety and effects on biomarkers. It features a patented form of nicotinamide riboside known as Niagen and holds FDA GRAS (Generally Recognized As Safe) certification. While focusing on a single active ingredient, it provides a consistent and well-studied method for increasing NAD+ levels.

Omre NMN + Resveratrol

Omre combines NMN with Resveratrol and BioPerine® (black pepper extract, often included to aid absorption). This blend is intended to support NAD+ restoration and contribute to overall cellular health. It is considered an option for those seeking a formulation that addresses multiple aspects of cellular aging within one product.

ProHealth Longevity NMN Pro Powder

ProHealth offers a sublingual NMN powder for users who may prefer flexibility in how they take the supplement and prioritize high purity. The brand is recognized for its commitment to extensive third-party testing and transparency, which may appeal to users who closely monitor their health data. The sublingual format is designed for absorption directly into the bloodstream.

Comparison of Top NAD+ Supplement Brands

Feature	Wonderfeel Youngr NMN	Tru Niagen	Omre NMN + Resveratrol	ProHealth NMN Pro Powder
Precursor Type	NMN	NR (Niagen)	NMN + Resveratrol	NMN
Typical Form	Capsule	Capsule, Powder	Capsule	Powder (Sublingual)
Purity Information	Stabilized, indicated high purity	Patented Niagen	Indicated 99% Pure NMN, 98% Resveratrol	Indicated 99%+ Pharmaceutical-Grade
Potential Synergistic Ingredients	Resveratrol, Olive Fruit Extract	None	Resveratrol, BioPerine®	None
Highlighted Benefit	Acknowledged for a multi-targeted formula supporting NAD+ levels	Noted for extensively studied NR with clinical backing and FDA GRAS status	Recognized for combining NMN with antioxidant support	Known for high-purity powder potentially offering flexibility
Potential Use Case	Supporting general cellular health and aging	Individuals seeking a clinically researched NR option	A combined approach to cellular health	Users who prefer specific preparation methods and high purity

Best Practices for Supporting NAD+ Levels

Complementing any supplement regimen with healthy lifestyle practices is generally recommended:

• Focus on a Balanced Diet: Research suggests that dietary patterns can influence NAD+ levels. A diet rich in nutrient-dense foods is generally encouraged.
• Engage in Regular Exercise: Physical activity has been linked to increased NAD+ synthesis in muscle tissue, which may complement the effects of supplementation.
• Prioritize Adequate Sleep: Sufficient and quality sleep is important for cellular repair and metabolic processes that are supported by healthy NAD+ levels.
• Consider Nutrient Combinations: Some studies explore combining NAD+ precursors with other nutrients, like TMG, which plays a role in metabolic pathways related to NAD+.

Conclusion

The question of what brand of NAD+ is the best does not have a single definitive answer, as the most suitable choice depends on individual factors and health objectives. For individuals seeking a comprehensive formula that includes a precursor and antioxidants, Wonderfeel Youngr NMN is frequently mentioned. If a well-researched NR formulation with substantial clinical evidence is preferred, Tru Niagen is a notable option. For those prioritizing ingredient purity and specific preparation methods, ProHealth Longevity NMN Pro Powder offers a high-purity option. The advised approach involves identifying personal health goals, such as enhancing energy or supporting long-term cellular function, and selecting a reputable brand that undergoes third-party testing and aligns with those goals. As with initiating any new supplement, consulting with a healthcare professional is recommended to ensure it is appropriate for your individual health situation.

For access to scientific literature on NAD+ metabolism and precursors, the National Institutes of Health (NIH) is a valuable resource.

Frequently Asked Questions

What is the difference between NMN and NR supplements?

NMN (Nicotinamide Mononucleotide) is utilized by the body in a metabolic step closer to NAD+. NR (Nicotinamide Riboside) is typically converted to NMN before contributing to NAD+ production.

Is NMN or NR potentially more effective for raising NAD+ levels?

Both NMN and NR are recognized for their ability to increase NAD+ levels. While NMN's pathway is more direct, both have scientific support for their role as precursors.

Are NAD+ supplements generally considered safe for daily use?

Based on current research, precursors like NMN and NR are generally considered safe for use as directed for limited periods. However, long-term safety is an area of ongoing study, and consulting a healthcare provider is always recommended.

How long might it take to notice effects from NAD+ supplements?

Experiences can vary. Some users have reported noticing effects such as increased energy or improved focus within several weeks, while potential longer-term benefits might become apparent over several months.

Why might some NAD+ supplements include Resveratrol?

Resveratrol is an antioxidant that, when included in formulations with NAD+ precursors, may offer protection against cellular stress and potentially support the activity of sirtuins, which are proteins linked to cellular health.

What does third-party testing involve and why is it important for NAD+ brands?

Third-party testing means an independent laboratory has assessed the supplement's composition to verify its ingredients, purity, and potency. This is important as it helps confirm the product's quality and ensures it contains what is listed on the label.

What might be some considerations for selecting NAD+ brands on a budget?

For those mindful of cost, brands like Double Wood NMN or Neurogan Health NMN are often mentioned as offering more accessible price points while maintaining manufacturing standards.

Is it possible to obtain sufficient NAD+ from diet alone?

While certain foods contain small quantities of NAD+ precursors, the amounts are typically not significant enough to substantially increase NAD+ levels in the body. For individuals seeking to elevate their levels, supplementation is often considered.