What is deficiency of vitamin K called?
The specific name for vitamin K deficiency in infants is Vitamin K Deficiency Bleeding (VKDB), previously known as hemorrhagic disease of the newborn. This condition primarily affects newborns in their first few months due to low vitamin K levels at birth and poor transfer through breast milk. In adults, there isn't a unique medical term; it's simply called vitamin K deficiency or, in symptomatic cases, a 'bleeding tendency' or 'coagulopathy'.
The Critical Role of Vitamin K
Vitamin K is a fat-soluble vitamin vital for synthesizing proteins necessary for blood clotting, such as prothrombin and factors VII, IX, and X. These proteins are essential for effective blood coagulation. Vitamin K exists as K1 (phylloquinone) in green leafy vegetables and K2 (menaquinone), produced by gut bacteria and found in some fermented foods. Insufficient vitamin K impairs the production of these clotting factors, increasing bleeding risk.
Causes and Risk Factors
Vitamin K deficiency is rare in healthy adults but newborns are particularly vulnerable.
Causes in Adults
Causes in adults include malabsorption disorders like celiac disease or cystic fibrosis, long-term antibiotic use, anticoagulants like warfarin, very low-fat diets, and severe liver disease.
Causes in Newborns
Newborns have low vitamin K levels due to limited transfer across the placenta, a sterile gut lacking bacteria to produce K2, low levels in breast milk, and parental refusal of the standard vitamin K injection.
Signs and Symptoms
Symptoms differ between adults and infants.
Symptoms in Adults
Adult symptoms include easy bruising, excessive bleeding, blood under nails, blood in urine or stool, poor bone mineralization, and heavy menstrual bleeding.
Symptoms in Infants with VKDB
Symptoms of VKDB include unexplained bruising, bleeding from the umbilical cord or circumcision site, vomiting blood or dark stools, pale skin, and potentially life-threatening intracranial hemorrhage.
Diagnosis and Treatment
Diagnosis involves reviewing symptoms and medical history, and blood tests like prothrombin time (PT) or international normalized ratio (INR) to measure clotting speed. Elevated PT/INR indicates impaired clotting.
Treatment depends on severity and age. Adults typically receive oral or subcutaneous vitamin K. Severe cases may require intravenous administration. Infants with VKDB receive immediate intravenous or subcutaneous vitamin K1, and severe bleeding may necessitate a blood transfusion.
Prevention and Dietary Sources
Prevention is crucial, especially for at-risk groups.
Prevention
The American Academy of Pediatrics recommends a single vitamin K injection at birth to prevent VKDB in newborns. Adults can prevent deficiency by eating a diet rich in vitamin K, treating malabsorption conditions, and careful monitoring on certain medications.
Dietary Sources of Vitamin K
Key dietary sources include green leafy vegetables like kale and spinach, fermented foods like natto, vegetable oils (soybean, canola), and some meat and dairy products (cheese, eggs, liver).
Comparison: Vitamin K Deficiency in Infants vs. Adults
| Feature | Infants (VKDB) | Adults (Deficiency) |
|---|---|---|
| Primary Cause | Low vitamin K transfer across placenta, sterile gut, low breast milk content | Malabsorption issues, dietary insufficiency, medications |
| Common Age | Primarily first 2-12 weeks of life (Late VKDB) | Can occur at any age, typically with underlying health issues |
| Specific Name | Vitamin K Deficiency Bleeding (VKDB) | No specific name, just 'vitamin K deficiency' |
| Symptoms | Bleeding from umbilical cord, circumcision site, nose; intracranial hemorrhage | Easy bruising, mucosal bleeding, blood in urine/stool |
| Most Serious Risk | Intracranial hemorrhage, potentially leading to brain damage or death | Life-threatening bleeding episodes, osteoporosis |
| Treatment | Vitamin K1 injection (IM or IV) | Oral, subcutaneous, or IV vitamin K supplementation |
| Prevention | Mandatory vitamin K injection at birth | Healthy diet, managing underlying health conditions |
Conclusion
While adults experience 'vitamin K deficiency', infants can suffer from the more specifically named and dangerous Vitamin K Deficiency Bleeding (VKDB). Vitamin K is crucial for blood clotting, and its deficiency, stemming from various causes in infants and adults, can result in uncontrolled bleeding. The severity in infants underscores the importance of preventative measures like the prophylactic injection at birth. Adults can largely prevent deficiency through a balanced diet. For further information, consult resources like the CDC.