What is Natamycin (E235)?
Preservative 235, commonly known as Natamycin, is a natural polyene macrolide antibiotic with antifungal properties. It's produced through the fermentation of the bacterium Streptomyces natalensis. Originally called pimaricin when discovered in 1955, it was later renamed natamycin. As a biopreservative, it effectively targets molds and yeasts while leaving beneficial bacteria unharmed, making it suitable for preserving fermented foods.
How Natamycin (E235) Works as a Preservative
Natamycin works by binding to ergosterol, a vital component of fungal cell membranes. This binding disrupts nutrient transport and inhibits fungal growth.
- Selective Targeting: It only affects fungi, which have ergosterol. Bacteria, lacking sterols, are not inhibited.
- No Membrane Damage: Instead of damaging the membrane, it forms a complex with ergosterol, disrupting intracellular processes.
- Low Dose Effectiveness: It is effective at low concentrations, preventing spoilage and mycotoxins with minimal use.
Applications of the 235 Preservative in Food
E235 is primarily used as a surface treatment because of its low water solubility, keeping it where mold and yeast typically grow. Common uses include application to the surface of various cheeses, on the casing of cured meats to inhibit mold and yeast, and added to yogurt and fermented milk products. It can also be used in some regions for beverages like juices and wines, and as a surface coating on un-yeasted baked goods.
Safety and Regulation of E235
Natamycin is widely considered safe (GRAS) by global food safety authorities, including the FDA, EFSA, and JECFA. Its safety profile is enhanced by minimal absorption in the digestive tract.
Natamycin (E235) vs. Synthetic Preservatives
Comparing E235 with synthetic preservatives like sorbates and benzoates highlights its unique properties. Natamycin is natural, primarily targets yeasts and molds by binding to ergosterol, has low water solubility staying on surfaces, does not interfere with beneficial bacteria, is tasteless, odorless, and colorless, and has a high safety profile with minimal body absorption. In contrast, synthetic preservatives are chemically synthesized, have a broader spectrum (potentially affecting some bacteria), permeate cell membranes, are water-soluble (penetrating food), may inhibit desired bacterial cultures, can impart bitter taste or affect color, and have general safety within limits though some allergic reactions are reported. For a more detailed comparison, please see {Link: FoodAdditives.net https://foodadditives.net/preservatives/natamycin/}.
Conclusion
Preservative 235, or Natamycin (E235), is an effective natural antifungal widely used in food. Produced through bacterial fermentation, it selectively inhibits yeasts and molds without affecting beneficial bacteria crucial for fermented foods. Its mechanism of binding to fungal ergosterol ensures efficacy at low concentrations. Approved by numerous regulatory bodies, E235 extends food shelf life, reduces spoilage, and provides a natural alternative to synthetic preservatives. While generally safe due to minimal absorption, those with mold or antibiotic sensitivities should be cautious. Natamycin is a key player in modern food safety and preservation.
For more detailed information on food additives, consult the European Food Safety Authority (EFSA) opinions on food additives.