What Probiotic Increases Estrogen? A Look at the Gut-Hormone Connection

The gut microbiome, specifically a collection of bacteria called the estrobolome, directly influences your body's estrogen levels. Understanding which probiotic increases estrogen is key to leveraging this gut-hormone connection for better hormonal health, especially during transitional life stages like menopause.

Quick Summary

The gut's estrobolome influences estrogen metabolism; certain probiotics can modulate this process. Specific Lactobacillus strains have shown promise in clinical trials for maintaining or increasing estrogen levels, benefiting hormonal balance.

Key Points

• Lactobacillus Brevis KABP052: A clinical trial suggests this strain helps maintain estrogen levels in peri- and postmenopausal women.

• The Estrobolome: This group of gut microbes metabolizes and regulates the body's estrogen.

• Beta-glucuronidase: This estrobolome-produced enzyme controls estrogen reabsorption from the gut.

• Animal Studies: Other strains like Lactobacillus plantarum and Bifidobacterium show potential benefits related to estrogen in animal models.

• Holistic Approach: Hormonal balance is supported by diet diversity, prebiotics, stress management, and probiotic use.

• Ongoing Research: The field is developing; consult a healthcare provider for personalized advice.

The Estrobolome: The Gut’s Role in Estrogen Regulation

The gut microbiome plays a significant role in hormonal health through a collection of bacteria known as the estrobolome. These microbes produce beta-glucuronidase, an enzyme essential for estrogen regulation. This enzyme de-conjugates estrogens in the gut, allowing them to be reabsorbed into the bloodstream instead of being excreted, thereby influencing circulating estrogen levels. Disruptions to the estrobolome's activity can lead to hormonal imbalances.

Specific Probiotic Strains That May Increase Estrogen

Research indicates that certain probiotic strains can influence estrogen levels. Lactobacillus brevis KABP052, for example, demonstrated the ability to help maintain serum estrogen levels in a study involving peri- and postmenopausal women. Other strains, including Lactobacillus plantarum, have shown potential in animal studies to increase estrogen. Lactobacillus reuteri and Lactobacillus rhamnosus have also shown benefits related to low estrogen in animal models. Bifidobacterium species contribute to estrogen metabolism and have shown promise in supporting bone health in estrogen-deficient mice. Multi-strain probiotics with Lactobacillus and Bifidobacterium are often suggested for overall gut health, which supports the estrobolome. Keep in mind that some strains with promising research may not be widely available yet.

Practical Steps to Support Your Estrobolome

Supporting your gut health is vital for hormonal balance. Consider these steps:

• Include Probiotic-Rich Foods: Fermented foods like yogurt, kefir, and kimchi offer beneficial bacteria.
• Eat Prebiotic Fibers: Foods like asparagus, garlic, and bananas feed beneficial gut bacteria.
• Diversify Your Diet: A variety of plant-based foods supports a diverse microbiome.
• Limit Antibiotics: Use antibiotics only when needed and consider probiotics afterward.
• Manage Stress: Stress impacts gut health, so practice relaxation techniques.

Comparison: Probiotics vs. Other Estrogen Therapies

Feature	Probiotics	Phytoestrogens	Hormone Replacement Therapy (HRT)
Mechanism	Indirectly modulate estrogen via the estrobolome.	Mimic estrogen from plants.	Direct hormone replacement.
Examples	L. brevis KABP052 (studied), L. plantarum, Bifidobacterium.	Soy, flaxseeds.	Prescription hormones.
Effectiveness	Emerging evidence; potential in specific strains.	Variable; can help with some symptoms.	Highly effective for severe symptoms but with risks.
Safety	Generally safe; minimal side effects.	Can be safe, but variable effects.	Potential side effects and long-term risks.
Availability	OTC supplements, fermented foods.	Diet and supplements.	Requires prescription.

Conclusion

While research on what probiotic increases estrogen is ongoing, Lactobacillus brevis KABP052 has shown promise in clinical settings. The primary takeaway is that supporting overall gut health and the estrobolome is a key strategy for hormonal balance. Probiotics can be part of this approach, but they should not replace medical advice or prescribed treatments. A holistic approach incorporating a healthy diet and professional guidance is recommended.

Explore the latest research on the gut-hormone axis via the National Institutes of Health (NIH).

Frequently Asked Questions

Can probiotics alone treat low estrogen?

No, probiotics support hormonal balance through the gut but are not a substitute for medical treatment for low estrogen. Always consult a healthcare provider for hormonal concerns.

How does the gut microbiome affect estrogen levels?

The estrobolome in the gut produces beta-glucuronidase, which allows for the reabsorption of estrogens into the bloodstream, thus influencing circulating levels.

What is the estrobolome?

The estrobolome is the collection of gut microbes that metabolize and modulate estrogen, playing a crucial role in maintaining estrogen balance.

Are there side effects to taking probiotics for hormonal balance?

Probiotics are generally safe, with potential mild, temporary digestive issues like bloating. It's advisable to start with a low dose and consult a healthcare professional.

Which probiotic is best for women with PCOS?

Research suggests certain probiotics and synbiotics can improve insulin resistance and hormone levels in women with PCOS, with multi-strain Lactobacillus and Bifidobacterium products often studied.

Can I get probiotics for estrogen from food?

Yes, fermented foods like yogurt and sauerkraut can provide beneficial bacteria to support a healthy estrobolome, though strain content varies.

How long does it take to see effects from probiotics on hormones?

Effects can vary, with some studies showing changes after 12 weeks. Consistent, long-term use may be needed for significant hormonal effects.