Nitrites, and their more stable counterparts, nitrates, are nitrogen compounds found everywhere in the natural world. They are a crucial part of the Earth's nitrogen cycle, occurring naturally in soil and water. Our dietary exposure comes from diverse sources, which can be grouped into natural origins and those added during food processing.
Natural Sources of Nitrite
Most people get the majority of their dietary nitrates (which the body can convert to nitrites) from vegetables.
Vegetables
- Leafy Greens: Vegetables like spinach, arugula, rocket, and lettuce are among the richest natural sources of nitrates. The nitrate content is influenced by factors such as light, temperature, and agricultural practices.
- Root Vegetables: Beetroot, carrots, and radishes are also significant sources of natural nitrates. Athletes often use beetroot juice to boost performance, which is a testament to its high nitrate content and the conversion to beneficial nitric oxide in the body.
- Other Vegetables: Celery, cabbage, parsley, and fennel also contain varying amounts of natural nitrates.
Water
Nitrates and nitrites are present in surface water and groundwater, where their concentration can fluctuate based on environmental factors. Contamination of drinking water can occur from agricultural runoff containing fertilizers, animal manure, and waste from septic systems. While the nitrite levels in water are typically negligible, high nitrate levels can be reduced to nitrite by bacteria and pose a risk, particularly to infants.
Processed Food Sources
Nitrite is intentionally added to certain foods as a preservative, color enhancer, and to inhibit the growth of harmful bacteria, especially Clostridium botulinum, the cause of botulism.
Cured and Processed Meats
Sodium nitrite (E250) and potassium nitrite (E249) are common additives used in a wide range of processed meats.
- Examples: Bacon, ham, sausages, hot dogs, bologna, salami, and pepperoni.
- Function: In these products, nitrite prevents the growth of bacteria, contributes to the characteristic pink color, and helps develop the distinct cured flavor.
Cheeses
Nitrates can be used in some cheese production to prevent undesirable microbial activity during the ripening process. Some cured meats and cheeses are explicitly labeled as “uncured” or “no added nitrates,” but these products often use celery powder, a natural source of nitrates, which are then converted to nitrites.
The Body's Internal Production
Our bodies also naturally produce nitrates and nitrites. In fact, a significant portion of the nitrite in our system comes from the endogenous conversion of nitrates from our diet and the natural nitrogen cycle. Bacteria in the mouth and gut facilitate the reduction of nitrates to nitrites. These compounds then circulate throughout the body and can be converted to nitric oxide, which plays a vital role in cardiovascular health by relaxing blood vessels.
Comparison of Nitrite and Nitrate Sources
| Feature | Natural Sources (Mainly Vegetables) | Processed Sources (Cured Meats) |
|---|---|---|
| Primary Compound | Nitrates ($NO_3^-$) are abundant; converted to nitrites ($NO_2^-$) in the body. | Nitrites ($NO_2^-$) are added directly as a preservative. |
| Health Context | Generally beneficial, thanks to co-occurring antioxidants like vitamin C, which prevent the formation of harmful nitrosamines. | Linked to the formation of nitrosamines, which can increase cancer risk, especially when cooked at high heat. |
| Function | Contribute to the production of nitric oxide, which supports cardiovascular health. | Preserve meat, enhance flavor and color, and prevent bacterial growth. |
| Exposure Level | Represents 80% or more of average dietary intake. | Represents a smaller portion of dietary intake, but is the focus of health concerns due to nitrosamine formation potential. |
What are the Health Implications?
The health impact of nitrite is not uniform and heavily depends on its source. Nitrites from vegetables are generally considered beneficial because vegetables contain antioxidants that inhibit the formation of harmful nitrosamines. However, the nitrites added to processed meats are a source of concern. When cooked at high temperatures alongside the proteins in meat, nitrites can react to form carcinogenic nitrosamines.
Authorities like the International Agency for Research on Cancer (IARC) classify processed meats as carcinogenic partly due to this process. The regulations on nitrite levels in processed foods are set to protect consumers, but mindful consumption is advised. Infants are particularly susceptible to methemoglobinemia from high nitrate exposure in drinking water, as their digestive system is more sensitive.
Conclusion
Nitrite is a compound with a dual nature, found in a surprising variety of sources from nutrient-rich vegetables to processed meats and drinking water. Its beneficial or harmful effects are largely dependent on its origin and how it interacts with other substances in the body. While the nitrites derived from plants are associated with positive health outcomes, those in processed meats, especially when heated, can form harmful compounds called nitrosamines. For a balanced diet, it is recommended to focus on a variety of whole plant foods while limiting the consumption of processed meats. Staying informed about the sources of nitrite allows consumers to make healthier, safer food choices.