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Which is better, magnesium citrate or magnesium glycinate?

4 min read

While the human body requires magnesium for over 300 enzymatic functions, not all magnesium supplements are created equal. Two of the most popular forms, magnesium citrate and magnesium glycinate, offer distinct benefits and are suited for different health objectives.

Quick Summary

Compares magnesium citrate and magnesium glycinate, detailing their differences in bioavailability, primary uses, and side effects. Clarifies which form is best for specific health goals like constipation relief, improved sleep, or anxiety reduction.

Key Points

  • Targeted Benefits: Magnesium glycinate is primarily for relaxation, sleep, and anxiety, while magnesium citrate targets digestive health and constipation.

  • Digestive Impact: Glycinate is gentle on the stomach and non-laxative, whereas citrate acts as a laxative, which can cause digestive upset in higher doses.

  • Bioavailability: Both forms are highly bioavailable, meaning they are well-absorbed by the body, especially when compared to inorganic forms like magnesium oxide.

  • Primary Uses: Use glycinate for daily relaxation, mood support, and muscle cramps; use citrate for occasional constipation relief.

  • Combined Use: For some, taking both forms can be beneficial—citrate for digestive issues and glycinate for evening relaxation.

In This Article

Understanding Magnesium Glycinate and Citrate

Magnesium is an essential mineral vital for nerve function, muscle relaxation, blood sugar regulation, and bone health. However, deficiencies are common, leading many people to turn to supplements. The key difference between magnesium supplements lies in the compound the mineral is bound to, which significantly affects its absorption and impact on the body. Magnesium glycinate and citrate are two popular, well-absorbed options, but their applications differ based on their unique properties.

Magnesium Glycinate: The Gentle, Calming Choice

Magnesium glycinate is formed when magnesium is bound to the amino acid glycine. This combination is highly bioavailable and gentle on the digestive system, making it an excellent choice for consistent, daily use without the risk of laxative effects. Glycine is a calming amino acid that supports neurotransmitters like GABA, which helps relax the nervous system and brain.

Key uses of magnesium glycinate include:

  • Sleep Improvement: The calming effects of glycine make it ideal for promoting restful sleep and helping those with insomnia or sleep maintenance issues.
  • Anxiety and Stress Reduction: Its soothing action on the nervous system can help lower feelings of anxiety and stress.
  • Muscle Relaxation: Glycinate is effective for reducing muscle tension and cramping, including nighttime leg cramps.
  • Overall Well-being: Due to its high absorption and gentle nature, it's a reliable choice for general supplementation to correct a magnesium deficiency.

Magnesium Citrate: The Digestive Health Aid

Magnesium citrate combines magnesium with citric acid, a natural acid found in citrus fruits. This combination is known for its ability to draw water into the intestines, acting as an osmotic laxative. While it is also highly bioavailable, its primary and most potent effect is on digestive health.

Key uses of magnesium citrate include:

  • Constipation Relief: It is a powerful and fast-acting remedy for occasional constipation.
  • Digestive Regularity: For those with sluggish digestion, magnesium citrate can help promote regular bowel movements.
  • Bowel Preparation: It is often used to cleanse the colon before medical procedures like a colonoscopy.

Magnesium Glycinate vs. Citrate Comparison Table

Feature Magnesium Glycinate Magnesium Citrate
Primary Purpose Sleep support, stress relief, muscle relaxation Digestive health, constipation relief
Digestive Impact Gentle on the stomach; less likely to cause diarrhea Acts as an osmotic laxative; may cause loose stools
Best for Long-Term Use Yes, due to minimal digestive side effects Only for occasional use, not recommended long-term for general supplementation due to laxative effects
Sleep & Anxiety Superior choice due to the calming amino acid glycine May cause relaxation but less effective for targeted sleep and anxiety
Bioavailability High, especially suitable for daily intake High, but its laxative effect limits its use for general repletion
Cost Generally higher priced than citrate Typically more affordable

Can You Take Both Magnesium Glycinate and Citrate?

Yes, it is possible to take both magnesium glycinate and citrate, as they serve different purposes. Some individuals find it effective to use magnesium citrate in the morning for digestive support and magnesium glycinate in the evening for its calming effects and to aid sleep. However, it is crucial to monitor your total magnesium intake and consult a healthcare professional before combining supplements.

Considerations for Choosing the Right Form

The best choice between magnesium glycinate and magnesium citrate depends entirely on your individual health needs and goals. There is no single "better" option, only the one that is more suitable for your specific purpose.

  • If you are seeking relief from stress, anxiety, or insomnia, magnesium glycinate is the superior choice. Its calming properties, combined with its high absorbability and gentleness on the stomach, make it ideal for daily, long-term use.
  • If your primary issue is occasional constipation, magnesium citrate is the more effective and targeted solution. Its laxative effect is precisely what is needed for digestive regularity.
  • For sensitive stomachs, magnesium glycinate is the clear winner. If magnesium citrate causes you any digestive discomfort, glycinate provides a high-quality, easily tolerated alternative for general magnesium supplementation.

Conclusion: Tailoring Your Supplement to Your Needs

In the debate of which is better, magnesium citrate or magnesium glycinate, the answer lies in your specific health objective. Both are highly bioavailable and effective forms of magnesium, but they excel in different areas due to their chemical structures. For promoting calmness and improving sleep quality, magnesium glycinate is the expert-recommended form. For addressing occasional constipation and supporting digestive health, magnesium citrate is the more appropriate and potent choice. By understanding these key differences, you can make an informed decision to better support your overall well-being. Always consult with a healthcare provider before starting any new supplement regimen to ensure it aligns with your unique health profile. The National Institutes of Health provides comprehensive information on magnesium and its functions at https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/.

What to Look for When Buying a Magnesium Supplement

When purchasing a magnesium supplement, look for third-party certifications like NSF or USP to ensure quality, safety, and purity. Ensure the elemental magnesium content is listed, as this indicates the amount of usable magnesium per dose. For magnesium glycinate, it's often recommended to start with a lower dose and increase gradually to assess tolerance, as some may experience slight drowsiness. For magnesium citrate, follow dosage instructions carefully to avoid excessive laxative effects.

Key considerations for purchasing include:

  • Purpose: Are you targeting sleep/anxiety (glycinate) or constipation (citrate)?
  • Digestive Sensitivity: If your stomach is sensitive, glycinate is the better option.
  • Form: Both come in capsules, powders, and liquids, so choose based on your preference.
  • Reputation: Select a reputable brand with transparent sourcing and testing.
  • Elemental Magnesium: Pay attention to the elemental content, not just the total dosage.

Frequently Asked Questions

Magnesium glycinate is widely considered the best choice for sleep and anxiety. It is bound to the amino acid glycine, which has a calming effect on the brain and nervous system, promoting relaxation and improving sleep quality.

Magnesium citrate is the better form for treating occasional constipation. Its structure acts as an osmotic laxative, drawing water into the intestines to soften stool and stimulate bowel movements.

Yes, you can take both forms together, but it's often more strategic to separate them. Many people take magnesium citrate in the morning for digestive support and magnesium glycinate at night for relaxation and sleep.

Both magnesium glycinate and magnesium citrate are organic forms that are highly bioavailable, meaning they are well-absorbed by the body, especially when compared to inorganic forms like magnesium oxide.

The most common side effect of magnesium citrate is its laxative effect, which can lead to loose stools, diarrhea, or upset stomach, especially at higher doses.

Yes, magnesium glycinate is gentler on the digestive system than magnesium citrate and is less likely to cause diarrhea or discomfort, making it a better option for those with sensitive stomachs.

Symptoms of a magnesium deficiency can include muscle cramps, fatigue, weakness, anxiety, irregular heartbeat, and sleep disturbances. A blood test can confirm low magnesium levels.

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.