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Why do I get hungover with wine? A deep dive into the science

5 min read

According to the National Institute on Alcohol Abuse and Alcoholism, consuming darker-colored spirits containing higher levels of congeners can worsen hangover symptoms. This may be why you get hungover with wine, especially red wine, more than with other types of alcohol, due to various compounds created during fermentation.

Quick Summary

Several compounds, including congeners, histamines, and tannins, are found in wine and can contribute to more intense hangover symptoms than other types of alcohol. The body's processing of these substances, along with common factors like dehydration and sleep disruption, plays a significant role in how you feel the next day. Individual sensitivities can further amplify these effects.

Key Points

  • Congeners in wine: Darker wines, especially reds, contain higher levels of congeners, which are fermentation byproducts that can worsen hangover severity.

  • Histamine sensitivity: Red wines contain higher levels of histamines, which can trigger allergic-like reactions and headaches in sensitive individuals.

  • Tannins and headaches: Some people report that the tannins found in red wine can cause headaches, possibly due to vaso-relaxation.

  • Sulfites are likely not the cause: True sulfite sensitivity is relatively rare and generally causes respiratory issues, not headaches, for most people.

  • General alcohol factors: Dehydration, poor sleep, and inflammation caused by alcohol consumption contribute to all hangovers, but can feel more severe with wine.

  • Mitigation strategies: Staying hydrated, eating food, pacing consumption, and choosing lighter wines can help reduce hangover symptoms.

In This Article

Unpacking the Components: More Than Just Alcohol

When you drink wine, you're not just consuming ethanol. The fermentation and aging process creates a complex mix of compounds that can affect your body differently. These additional components are often the key reason for the disproportionately severe hangovers some people experience after drinking wine.

Congeners: The Darker the Drink, the Worse the Hangover?

Congeners are chemical byproducts of fermentation that give alcoholic beverages their unique flavor and aroma. Darker drinks, like red wine and whiskey, are known to have higher concentrations of these compounds than lighter spirits, such as vodka. Research suggests that high levels of congeners are associated with worse hangovers, possibly because the body has to work harder to break down both the ethanol and these extra chemicals. The presence of congeners in red wine, often elevated by oak aging, can therefore contribute to more intense hangover symptoms.

Histamines and Tyramines: The Migraine Triggers

Wine, especially red wine, contains biogenic amines like histamines and tyramines. For individuals with a sensitivity to these compounds or a deficiency in the enzyme that breaks them down (diamine oxidase or DAO), consuming wine can trigger an allergic-like reaction. This can lead to headaches, flushing, and other hangover-related discomforts. The levels of histamines can vary depending on the wine's production process, with some natural or barrel-fermented wines having higher concentrations.

Tannins and Sulfites: The Misunderstood Culprits

Tannins are naturally occurring phenolic compounds in grape skins, seeds, and stems that give wine its antioxidant properties. Some people report that high-tannin wines, particularly full-bodied reds, cause headaches. While the exact mechanism is not fully understood, it may involve vaso-relaxation, which affects blood vessels. Similarly, sulfites, used as a preservative in wine, are often blamed for hangovers. However, the evidence is mixed, and true sulfite sensitivity, which affects a small percentage of the population and primarily causes asthma-like symptoms, is not the main cause of headaches for most people.

The Physiology of a Wine Hangover

Beyond the specific compounds in wine, general physiological effects of alcohol also play a role, sometimes amplified by the wine's unique composition.

Dehydration's Role

All alcohol is a diuretic, meaning it causes your body to increase urine output and lose fluids. This can lead to dehydration, which is a major contributor to hangover symptoms like thirst, fatigue, and headaches. While dehydration is a factor for any alcohol, the complexity of wine can exacerbate the overall strain on the body, making dehydration feel more severe.

Inflammation and Irritation

Alcohol increases inflammation in the body, which contributes to the general feeling of being unwell during a hangover. Some compounds in wine, like congeners, may further increase this inflammatory response. Additionally, alcohol directly irritates the lining of the stomach and intestines, leading to nausea and stomach discomfort.

The Impact on Sleep

While alcohol may help you fall asleep faster, it disrupts your sleep architecture, leading to poor quality and fragmented rest. This lack of restful sleep contributes significantly to the fatigue and irritability often associated with a hangover.

Wine vs. Other Alcohols: A Comparison of Hangover Factors

Factor Red Wine White Wine Clear Spirits (e.g., Vodka) Darker Spirits (e.g., Bourbon)
Congener Content High Low Very Low High
Histamine Content High Low Not Applicable Not Applicable
Tannin Content High Low Not Applicable Varies (often high)
Sulfite Content Varies (often less than whites) Varies (often more than reds) Not Applicable Not Applicable
Sugar Content Varies Varies (can be high) Varies Varies
Inflammation Potential High Medium Low High
Likelihood of Severe Hangover High Low to Medium Low High

How to Mitigate a Wine Hangover

If you find yourself frequently asking, why do I get hungover with wine?, there are proactive steps you can take to minimize the next-day misery. The key is to understand your body's specific sensitivities and make adjustments to your drinking habits.

  • Stay hydrated: Drink a glass of water for every glass of wine you consume. This helps combat the diuretic effects of alcohol.
  • Eat before and while drinking: Having food in your stomach, especially fatty foods, slows the absorption of alcohol into your bloodstream.
  • Pace yourself: Slow down your consumption. This gives your body more time to process the alcohol and other compounds effectively.
  • Choose your wine wisely: If you suspect you have a sensitivity to histamines or tannins, opt for lighter-bodied red wines, rosés, or white wines. Choosing Certified Organic wines can also reduce the amount of added sulfites.
  • Consider an antihistamine: For those with histamine intolerance, taking an antihistamine before drinking red wine may help reduce symptoms, though it's best to consult a doctor first.
  • Avoid mixing drinks: While mixing drinks doesn't inherently worsen hangovers, it often leads to consuming more alcohol overall. Sticking to one type can help you moderate your intake.

Conclusion: Navigating Wine for a Better Morning

There isn't one single cause for a wine hangover, but rather a perfect storm of factors including congeners, histamines, and tannins, all conspiring alongside the general effects of alcohol. For many, red wine's complex composition is the primary culprit behind those severe headaches and feelings of fatigue. By paying attention to your body's reactions, staying hydrated, and being mindful of your consumption, you can enjoy wine with a much lower risk of a painful morning after. Understanding the science behind your body's response is the first step toward a more pleasant and responsible drinking experience. For more in-depth information on the physiological effects of alcohol, consider reviewing information from reputable sources like the National Institutes of Health.

Why do I get hungover with wine?: Key Points

  • Congeners in wine: Darker wines, especially reds, contain higher levels of congeners, which are fermentation byproducts that can worsen hangover severity.
  • Histamine sensitivity: Red wines contain higher levels of histamines, which can trigger allergic-like reactions and headaches in sensitive individuals.
  • Tannins and headaches: Some people report that the tannins found in red wine can cause headaches, possibly due to vaso-relaxation.
  • Sulfites are likely not the cause: True sulfite sensitivity is relatively rare and generally causes respiratory issues, not headaches, for most people.
  • General alcohol factors: Dehydration, poor sleep, and inflammation caused by alcohol consumption contribute to all hangovers, but can feel more severe with wine.
  • Mitigation strategies: Staying hydrated, eating food, pacing consumption, and choosing lighter wines can help reduce hangover symptoms.

Frequently Asked Questions

While often blamed, sulfites are not the primary cause of headaches for most people. True sulfite sensitivity is rare and more likely to cause asthma-like symptoms or hives. Other factors like congeners and histamines are more likely culprits.

Red wines tend to cause worse hangovers for many due to higher concentrations of congeners, histamines, and tannins. White wines typically contain fewer of these compounds, leading to a less severe next-day feeling.

For individuals with a specific intolerance to histamines, taking an antihistamine beforehand might help reduce some symptoms like headaches. However, it will not prevent the hangover entirely, as other factors like dehydration and congeners are still at play.

Yes, drinking water alongside wine is one of the most effective strategies for preventing a hangover. Alcohol is a diuretic, and staying hydrated helps counteract its dehydrating effects, which are a major cause of headache and fatigue.

Facial flushing can be a sign of a deficiency in the enzyme aldehyde dehydrogenase (ALDH), which is responsible for breaking down a toxic byproduct of alcohol metabolism called acetaldehyde. This can lead to more severe hangover symptoms.

There is no definitive hangover cure. While certain methods can help alleviate symptoms, the most effective way to prevent a hangover is to drink in moderation, stay hydrated, and eat before consuming alcohol.

Not necessarily. The severity of a hangover is more dependent on factors like congeners, histamines, and overall alcohol intake rather than price. However, some lower-quality commercial wines may use techniques that alter these components.

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.