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Are there any side effects of stevia? Understanding the safety profile

4 min read

Over one-third of American adults consume low-calorie or zero-calorie sweeteners, and for many, stevia is a preferred option due to its natural origin. However, concerns often arise about the potential side effects of stevia, questioning its reputation as a safe alternative to sugar. This article explores the evidence regarding the safety of highly purified stevia, addressing common worries and outlining what to look for on product labels.

Quick Summary

This guide examines the scientific evidence surrounding the safety of stevia, discussing potential side effects like digestive upset linked to additives and highlighting its generally recognized safe status by regulatory bodies when highly purified. It also covers potential drug interactions and allergic reactions.

Key Points

  • Generally Recognized as Safe (GRAS): Highly purified steviol glycosides have been approved by the FDA as safe for consumption when used in moderation.

  • Digestive Issues Often Caused by Additives: Bloating, gas, and nausea are typically caused by sugar alcohols like erythritol, commonly mixed into stevia products, not the stevia itself.

  • Rare Allergic Reactions: Allergies are very uncommon and primarily a concern for those with sensitivities to the Asteraceae family (e.g., ragweed); however, purified extracts remove allergenic proteins.

  • Potential Drug Interactions: Stevia's effects on blood sugar and blood pressure mean it can interact with medications for diabetes and hypertension; medical consultation is advised.

  • Avoid Unrefined Products: The FDA has not approved whole stevia leaves or crude extracts for use as sweeteners due to a lack of safety information.

  • No Long-Term Toxicity Evidence: Long-term studies and reviews by regulatory bodies have found no evidence of toxicity, cancer risk, or organ damage related to moderate consumption.

  • Taste Considerations: Some people may notice a mild, bitter aftertaste with stevia compared to table sugar.

In This Article

What is Stevia? A Closer Look at the Sweetener

Stevia is a zero-calorie sweetener derived from the leaves of the Stevia rebaudiana plant, native to South America. The sweet components, called steviol glycosides, are extracted and purified to create the stevia sweeteners found in many food and beverage products. While crude stevia leaf and extracts are not approved for sale as sweeteners in the U.S., highly purified steviol glycosides (≥95%) have been approved by the U.S. Food and Drug Administration (FDA) and are considered "Generally Recognized as Safe" (GRAS).

Potential Side Effects of Stevia

When consumed in moderate quantities, highly purified stevia is generally considered safe for most people and rarely causes adverse side effects. However, some individuals may experience issues related to the product's formulation or pre-existing sensitivities.

Digestive Issues

One of the most frequently reported side effects is gastrointestinal discomfort. This is often caused not by the steviol glycosides themselves, but by added ingredients, such as sugar alcohols like erythritol, sorbitol, and xylitol. When consumed in large amounts, these sugar alcohols can cause symptoms such as:

  • Bloating and gas
  • Nausea and cramping
  • Mild diarrhea

Allergic Reactions

Allergic reactions to stevia are extremely rare. The primary concern relates to cross-reactivity for individuals with allergies to plants in the Asteraceae family, which includes ragweed, daisies, and chrysanthemums. Highly purified stevia products, however, are processed to remove the proteins that trigger allergic responses, making the risk very low. Symptoms of a reaction might include itching in the mouth or throat, swelling, or hives.

Drug Interactions

Stevia's potential effects on blood sugar and blood pressure mean it can interact with certain medications. Individuals on the following medications should consult a doctor before using stevia consistently:

  • Antidiabetic drugs: Since stevia may help lower blood sugar, combining it with diabetes medication could cause blood glucose levels to drop too low.
  • Antihypertensive drugs: Stevia has blood pressure-lowering properties, which could enhance the effect of medications used to treat high blood pressure, leading to blood pressure that is too low.
  • Lithium: Stevia has a diuretic effect, which could potentially affect how the body excretes lithium.

Comparison Table: Stevia vs. Sugar and Sugar Alcohols

Feature Stevia (Purified Extract) Sugar (Sucrose) Sugar Alcohols (e.g., Erythritol)
Calories Zero ~16 calories per tsp Fewer than sugar
Glycemic Index Zero (no impact on blood sugar) High (can cause blood sugar spikes) Low (less impact than sugar)
Aftertaste Can have a slightly bitter or licorice-like taste None (neutral) Can have a cooling sensation
Digestive Impact Often benign, but additives like sugar alcohols can cause issues Generally none, unless consumed in excessive amounts Can cause bloating, gas, and diarrhea in large quantities
Best Use Drinks, baking (with adjustments), moderate everyday use Baking, general sweetening (in moderation) Confectionery, sugar-free gum, products for diabetics

Unsafe Forms and Potential Concerns

It is important to differentiate between highly purified steviol glycosides and unrefined stevia products. The FDA does not recognize whole stevia leaves or crude extracts as safe for use in food, as there is insufficient safety data. Concerns have been raised about potential risks associated with these unpurified forms, though they are not approved for commercial food use. Some early studies on less-refined stevia products raised concerns about fertility and hormonal effects, but modern, large-scale studies on the high-purity extracts approved for sale have not found evidence to support these claims.

What the Experts Say: Regulatory Approvals

Worldwide regulatory bodies have affirmed the safety of highly purified stevia extracts. The Joint FAO/WHO Expert Committee on Food Additives (JECFA), the FDA, and the European Food Safety Authority (EFSA) have all established an Acceptable Daily Intake (ADI) level for steviol glycosides. This indicates that moderate, regular consumption is not linked to long-term health risks like toxicity, cancer, or organ damage.

Conclusion: The Bottom Line on Stevia Side Effects

In conclusion, highly purified stevia extract is a safe, zero-calorie sweetener for most people when consumed within established acceptable daily intake limits. The potential side effects commonly associated with stevia, such as digestive upset, are most often caused by added ingredients like sugar alcohols rather than the stevia extract itself. While allergic reactions are rare, individuals with allergies to related plants should exercise caution. Those with diabetes or blood pressure issues should consult a doctor due to possible drug interactions. For the average consumer looking to reduce sugar intake, purified stevia remains a viable and safe alternative.

For more detailed information on sweeteners, visit: FDA Guidance on Sweeteners

Considerations for Different Stevia Users

  • For diabetics: While pure stevia does not affect blood sugar, it's crucial to check labels for additives like dextrose or maltodextrin that can impact glucose levels.
  • For those with digestive sensitivity: Pay close attention to ingredients lists and consider a pure stevia extract without sugar alcohols to minimize bloating and gas.
  • For pregnant or breastfeeding women: While purified stevia is generally considered safe, there is less definitive research. It is best to consult a healthcare provider for personalized advice.

By being an informed consumer and choosing highly purified products, most people can safely enjoy the benefits of stevia without experiencing negative side effects.

Frequently Asked Questions

Yes, but this is typically caused by sugar alcohols like erythritol, which are often mixed with stevia extracts, not the stevia itself. Pure stevia is generally not associated with these issues.

No. Earlier, controversial animal studies suggested potential negative effects on fertility, but extensive modern research on purified stevia has found no evidence to support these claims in humans.

Stevia has mild blood pressure-lowering properties, which can be beneficial for some. However, individuals with low blood pressure or those taking blood pressure medication should monitor their intake and consult a doctor.

Yes, pure stevia does not raise blood sugar levels and is often recommended for those with diabetes. However, some products contain additives like dextrose or maltodextrin that can impact blood glucose, so it is important to read labels.

Allergic reactions to highly purified stevia extract are very rare. People with allergies to ragweed or other Asteraceae plants might have a theoretical risk of cross-reactivity, but purified extracts minimize this risk.

No, the FDA has not approved whole stevia leaves or crude extracts for use as sweeteners due to insufficient safety data. Only highly purified steviol glycosides are considered safe for commercial food products.

Some people report a mild, bitter or licorice-like aftertaste, which is characteristic of the steviol glycosides in stevia. This can vary by brand and product formulation.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.