Does MSM Raise Blood Pressure? A Look at the Scientific Evidence

October 28, 2025 •

3 min read

Research in multiple human trials, including a 16-week study, found no significant difference in blood pressure for participants taking MSM compared to a placebo group. Given its growing popularity, a common question is, does MSM raise blood pressure, a valid concern for anyone managing their cardiovascular health.

Quick Summary

Current scientific evidence indicates that MSM supplementation does not significantly elevate blood pressure and is generally well-tolerated. Clinical studies show no adverse effects on blood pressure in healthy and overweight individuals at standard doses. Some research suggests potential indirect cardiovascular benefits due to its anti-inflammatory effects.

Key Points

No Blood Pressure Elevation: Human studies, including randomized controlled trials, show no significant increase in blood pressure linked to MSM supplementation.
Cardiometabolic Benefits: Research on overweight and obese adults found that MSM consumption increased 'good' HDL cholesterol levels, indicating potential cardiovascular health benefits.
Anti-Inflammatory Action: MSM exhibits anti-inflammatory effects by modulating inflammatory markers, which can contribute positively to overall cardiovascular health.
Generally Safe: Classified as 'Generally Recognized As Safe' (GRAS) by the FDA, MSM has a strong safety profile with minimal, mild side effects at recommended doses.
Low Side Effect Profile: Adverse effects like mild gastrointestinal issues are rare and no more frequent than with a placebo, with no major reported adverse events concerning blood pressure.
NSAID Alternative: For those concerned about the blood pressure-raising effects of NSAIDs, MSM provides a safer alternative for managing inflammation and pain.

Methylsulfonylmethane, or MSM, is a sulfur-containing compound widely known for its anti-inflammatory and antioxidant properties. It is commonly used to alleviate joint pain and inflammation, particularly for individuals with osteoarthritis. However, when considering any new supplement, understanding its impact on core health metrics like blood pressure is crucial.

The Direct Link Between MSM and Blood Pressure

Numerous human studies have investigated the safety and effects of MSM, with particular attention paid to cardiometabolic markers. The results consistently indicate that MSM does not appear to have a negative impact on blood pressure, even with sustained use.

Clinical Trial Findings

Multiple studies have shown no significant change in systolic or diastolic blood pressure in participants taking daily MSM compared to placebo groups. One 16-week trial on overweight and obese adults specifically noted this finding. This study also observed a potential positive effect on HDL cholesterol levels, a marker of cardiovascular health.
Another safety analysis in low back pain patients also found no significant adverse effects of MSM on blood pressure.

Potential Indirect Cardiovascular Benefits

While MSM does not raise blood pressure, its anti-inflammatory and antioxidant properties might offer indirect benefits for cardiovascular health. Chronic inflammation is a risk factor for cardiovascular disease and hypertension. By reducing inflammation and oxidative stress, MSM may support a healthier cardiovascular system.

What the Science Says vs. Common Concerns

The FDA has granted MSM a 'Generally Recognized As Safe' (GRAS) designation, supporting its safety profile at typical doses. Its safety has been extensively studied.

Side Effects and Safety Profile

Side effects from MSM are typically mild, mostly gastrointestinal issues like stomach upset, which are not more frequent than in placebo groups. No major adverse events related to blood pressure have been reported in studies using doses up to 4 grams daily. It's always advisable to consult a healthcare professional before starting any new supplement, especially with existing health conditions or medications.

Comparison: MSM vs. NSAIDs for Pain Relief and Blood Pressure

Comparing MSM to NSAIDs (nonsteroidal anti-inflammatory drugs) for pain relief is useful due to NSAIDs' known effects on blood pressure.


Feature	MSM (Methylsulfonylmethane)	NSAIDs (e.g., Ibuprofen, Naproxen)
Effect on Blood Pressure	No significant effect observed in most clinical trials.	Can raise blood pressure, especially with long-term use.
Mechanism of Action	Reduces inflammation and oxidative stress.	Blocks COX enzymes.
Safety Profile	Generally safe with minimal GI side effects.	Potential for GI bleeding, kidney issues, and increased blood pressure with long-term use.
Cardiovascular Risk	Not linked to increased cardiovascular risk; potential benefits suggested.	Long-term use can increase risk of heart attack and stroke.

Key Takeaways for Your Health

MSM does not significantly raise blood pressure, based on human clinical evidence.
It is generally well-tolerated and safe, with most side effects being mild stomach issues.
MSM's anti-inflammatory properties may offer indirect cardiovascular support.
For those concerned about NSAID cardiovascular risks, MSM may be a safer alternative for pain management.
Professional medical advice is recommended before adding MSM to your regimen, especially with a pre-existing condition.

Conclusion

Scientific evidence indicates that MSM supplementation does not cause a significant increase in blood pressure. Its anti-inflammatory effects may even support overall cardiovascular health by combating inflammation. Current data suggests MSM is a safe and well-tolerated supplement, even for those concerned about hypertension. Always consult with a healthcare provider regarding your specific health needs and supplement use. Examine.com provides further detailed analysis on the evidence-based effects of MSM.

Frequently Asked Questions

Based on current clinical evidence, MSM does not appear to negatively affect blood pressure and is considered safe for individuals with hypertension. However, it is crucial to consult your doctor before starting any new supplement, especially if you are on blood pressure medication.

There is no specific evidence to suggest that MSM interferes with blood pressure medication. However, due to its anti-inflammatory effects, it is always wise to discuss supplement use with your doctor to ensure it does not interact with your prescribed medication or overall treatment plan.

The cardiovascular effects of MSM appear to be neutral or potentially beneficial. Studies show no significant adverse impact on blood pressure and some research indicates it may help improve HDL cholesterol levels, a positive marker for heart health.

If you are monitoring your blood pressure, you should continue to do so consistently when starting a new supplement. While studies suggest MSM does not raise blood pressure, consulting your doctor and tracking your readings is the best way to ensure it is not having an unexpected effect on your individual health.

Yes, studies have shown MSM to be safe for long-term use (up to 16 weeks in some trials) with no significant adverse effects on blood pressure or other clinical markers. As always, medical supervision is recommended for extended use.

Yes, certain supplements can affect blood pressure, including licorice root, ephedra, and high doses of caffeine. It is important to research any supplement before taking it and consult a healthcare provider, especially if you have pre-existing hypertension.

There is no direct evidence that MSM lowers blood pressure. Its potential benefits to cardiovascular health are primarily indirect, stemming from its anti-inflammatory and antioxidant properties. It should not be considered a treatment for hypertension.