Exploring the Evidence: Does Vitamin C Increase Progesterone Levels?

October 14, 2025 •

4 min read

According to research published in Fertility and Sterility, a study found that women who took 750mg of vitamin C per day experienced a 77% increase in progesterone levels. This compelling finding has led many to question: Does vitamin C increase progesterone levels and what is the science behind this connection?

Quick Summary

Evidence suggests vitamin C can elevate progesterone, especially for individuals with luteal phase defects. It functions as an antioxidant, protecting the ovaries and supporting the corpus luteum, which is crucial for progesterone synthesis. Dietary changes and supplements are key considerations.

Key Points

Supports Progesterone Production: Clinical studies have shown that vitamin C supplementation can significantly increase progesterone levels in women, particularly those with low levels or luteal phase defects.
Acts as a Potent Antioxidant: Vitamin C's primary mechanism is its antioxidant function, which protects the cells of the ovaries and the corpus luteum from damage caused by oxidative stress.
Improves Luteal Phase Defects: Research demonstrates that vitamin C supplementation can lead to improvements in luteal phase defects, increasing fertility in certain cases.
Works Synergistically with Other Nutrients: Vitamin C's effects on hormones are enhanced when combined with other essential nutrients, such as Vitamin E and B vitamins.
Requires a Holistic Approach: While supplements can target specific deficiencies, achieving optimal progesterone levels is best accomplished through a balanced diet, stress management, and regular moderate exercise.

The Connection Between Vitamin C and Progesterone

Progesterone is a crucial hormone in the female reproductive cycle, playing a vital role in regulating menstruation and supporting early pregnancy. Low progesterone can lead to issues like luteal phase defects, making it difficult to sustain a pregnancy. Vitamin C, a powerful antioxidant, has been shown to play a significant role in supporting hormonal balance, particularly in the production of progesterone.

The Role of Antioxidants in Hormone Production

Oxidative stress, an imbalance between free radicals and antioxidants in the body, can damage cells and negatively impact reproductive health. The ovaries, where progesterone is produced, are particularly susceptible to this damage. Vitamin C protects the cells within the ovarian follicles from this oxidative stress. By safeguarding these cells, vitamin C ensures the health of the corpus luteum, the temporary endocrine structure that forms after ovulation and is responsible for producing progesterone.

Scientific Studies on Vitamin C and Progesterone

Several studies have explored the direct impact of vitamin C supplementation on progesterone levels. The most notable is a clinical trial involving women with luteal phase defects. For women in the study who received 750mg of vitamin C daily over three menstrual cycles, their serum progesterone levels were significantly elevated compared to a control group. This study demonstrated a 77% increase in serum progesterone levels in the treatment group, with 53% of participants showing an improvement in their luteal phase defect. While some research, particularly involving assisted reproductive technologies, has yielded mixed results, the association between vitamin C and progesterone production, especially in cases of deficiency, remains strong.

Dietary Sources vs. Supplements for Progesterone Support

While studies often use specific supplement dosages, incorporating vitamin C into your diet through food is the primary recommendation for overall health and hormonal balance. The body is designed to absorb nutrients most effectively from whole foods. However, supplements can be useful for those with specific deficiencies or health goals, such as correcting a luteal phase defect.

Foods High in Vitamin C

Citrus Fruits: Oranges, grapefruits, lemons, and limes are classic sources.
Berries: Strawberries, kiwis, raspberries, and blueberries pack a significant vitamin C punch.
Cruciferous Vegetables: Broccoli, Brussels sprouts, and cauliflower are excellent sources.
Peppers: Red and green bell peppers are exceptionally rich in vitamin C.
Dark Leafy Greens: Kale and spinach contain good amounts of the vitamin.

Considerations for Supplementation

For those considering supplementation to boost progesterone, a balanced and informed approach is essential. The dosage used in successful studies (750mg) is higher than the standard daily recommended intake, highlighting the need for medical guidance. Different forms of vitamin C supplements, such as simple ascorbic acid or buffered mineral ascorbates like Ester-C, are available. While some variations in absorption and effects have been noted, standard ascorbic acid is generally well-absorbed and cost-effective. It is also important to note that Vitamin C works synergistically with other nutrients, such as Vitamin E, further supporting female reproductive health.

Lifestyle Factors and Holistic Hormone Support

Optimizing progesterone levels involves more than a single nutrient; it requires a holistic approach to diet and lifestyle. Stress, for example, is a significant factor in hormonal imbalance. The body's production of the stress hormone cortisol can compete with and suppress progesterone production, in a mechanism known as the "pregnenolone steal". Managing stress is therefore critical.

Comparison of Progesterone Support Strategies


Strategy	Mechanism	Key Nutrients/Factors	Considerations
Vitamin C Supplementation	Provides potent antioxidant support, protecting ovarian cells and aiding the corpus luteum.	Ascorbic Acid, Antioxidants	Consult a doctor for appropriate dosage, particularly for luteal phase defects.
Balanced Diet	Supplies all necessary nutrients for overall endocrine function and reproductive health.	Zinc, Magnesium, B Vitamins, Healthy Fats, Antioxidants	Provides a wide range of synergistic nutrients naturally.
Stress Management	Reduces cortisol levels, which can suppress progesterone production.	Mindfulness, Yoga, Deep Breathing	Crucial for addressing the root cause of hormonal imbalance.
Moderate Exercise	Improves circulation, helps manage stress, and maintains healthy body weight, all supportive of hormone function.	Physical Activity	Excessive exercise can increase cortisol and be counterproductive.
Quality Sleep	Allows the body to regulate hormone production and reduce stress hormones.	Adequate Sleep (7-9 hours)	Poor sleep directly impacts hormone regulation.

Conclusion

Yes, studies have shown that vitamin C can help increase progesterone levels, particularly in women with luteal phase defects. This is largely due to its potent antioxidant properties, which protect ovarian tissues and support the function of the progesterone-producing corpus luteum. While high-dose supplementation can be effective under medical supervision, a nutrient-dense diet rich in vitamin C and other supportive nutrients like B6 and zinc, combined with healthy lifestyle habits such as stress management and moderate exercise, offers a powerful and holistic approach to supporting optimal progesterone levels and overall hormonal health. Always consult a healthcare provider before beginning any new supplement regimen, especially when addressing hormonal concerns.

This article is for informational purposes only and is not medical advice. Consult with a healthcare professional before starting any new diet or supplement plan.

Frequently Asked Questions

Vitamin C influences progesterone production by acting as a crucial antioxidant that protects the ovarian cells from damage caused by oxidative stress. It also supports the function of the corpus luteum, the structure responsible for producing progesterone after ovulation.

While consuming vitamin C-rich foods is essential for overall hormonal health and provides numerous benefits, studies showing a significant increase in progesterone levels often used specific, higher dosages via supplements. A balanced diet is a critical foundation, but supplementation may be needed for targeted effects, under medical guidance.

A luteal phase defect is a condition involving insufficient progesterone during the second half of the menstrual cycle, which can hinder embryo implantation. Vitamin C has been shown to help resolve this by significantly increasing progesterone levels.

One prominent study showed positive results for women with luteal phase defects using a daily dosage of 750mg of vitamin C. It is important to consult a healthcare provider for personalized recommendations on dosage.

Vitamin C is generally safe, as it is water-soluble and excess amounts are excreted. However, excessive intake can lead to side effects like digestive upset or, in rare cases, kidney stones. Always adhere to medical advice regarding dosage.

Other important nutrients for supporting progesterone levels include Vitamin B6, zinc, magnesium, and healthy fats. These nutrients support overall hormonal balance and production pathways.

Chronic stress increases cortisol, a hormone that can suppress progesterone production. Vitamin C helps regulate cortisol levels and supports the adrenal glands, which helps mitigate the negative impact of stress on hormonal balance.