The Core of Visbiome: The De Simone Formulation
Visbiome is a high-potency probiotic that contains 8 specific strains of live, freeze-dried bacteria. This specific combination is known as the 'De Simone Formulation,' named after Professor Claudio De Simone, M.D., who created and developed this unique blend. The formulation is the culmination of extensive research aimed at creating a synergistic mix of bacteria to support digestive health. The inclusion of multiple, well-researched strains is a key differentiator in the probiotic market, where many products offer only one or a few strains.
The 8 Probiotic Strains in Visbiome
Visbiome's strength lies in its diverse microbial composition. The eight strains are carefully selected to work together, supporting a balanced and healthy gut flora. This multi-strain approach is what sets it apart from many single-strain probiotic supplements. The eight specific strains are:
- Streptococcus thermophilus (DSM 24731 / SD5207)
- Bifidobacterium breve (DSM 24732 / SD5206)
- Bifidobacterium longum (DSM 24736 / SD5219) (recently reclassified as B. lactis)
- Bifidobacterium infantis (DSM 24737 / SD5220) (recently reclassified as B. lactis)
- Lactobacillus acidophilus (DSM 24735 / SD5212)
- Lactobacillus plantarum (DSM 24730 / SD5209)
- Lactobacillus paracasei (DSM 24733 / SD5218)
- Lactobacillus delbrueckii subspecies bulgaricus (DSM 24734 / SD5210) (recently reclassified as L. helveticus)
The Importance of a Multi-Strain Probiotic
Rather than relying on a single type of bacteria, the multi-strain approach is designed to introduce a wider variety of beneficial microorganisms to the gut. The human gut microbiome is a complex ecosystem, and a diverse range of bacterial species is considered beneficial for maintaining a healthy balance. This is particularly important for individuals managing conditions where the gut flora is imbalanced, such as irritable bowel syndrome (IBS) or pouchitis. Each strain may offer different benefits or thrive in different parts of the digestive tract, leading to a more comprehensive effect. For example, some Lactobacillus species are known to colonize the small intestine, while Bifidobacterium species are more prevalent in the large intestine.
Comparison: Visbiome vs. Other Probiotics
One of the key points of confusion in the probiotic market stems from the history of the De Simone Formulation and its relationship with the probiotic product VSL#3. Originally, the De Simone Formulation was sold under the VSL#3 brand. However, the licensing agreement between Professor De Simone and VSL Pharmaceuticals, Inc., expired in 2016. Following this, the De Simone Formulation became available under the brand name Visbiome in the United States and Vivomixx in Europe, while the VSL#3 brand continued to sell a different formulation.
Visbiome and the Legacy of VSL#3
For consumers seeking the exact probiotic blend used in many of the historical clinical studies for conditions like pouchitis, Visbiome is the product that carries on the original De Simone Formulation. This distinction is crucial for those who rely on specific, evidence-backed formulations for therapeutic use. The new VSL#3, while still a probiotic, does not contain the same bacterial strains or concentration ratios as the original.
| Feature | Visbiome (De Simone Formulation) | VSL#3 (Post-2016 Formulation) |
|---|---|---|
| Number of Strains | 8 specific strains | 8 strains (different from the De Simone blend) |
| Formulation | Original De Simone Formulation | Different formulation after 2016 |
| Clinical Trials | Backed by extensive research on the original formulation | Research on the original formula does not apply |
| Target Conditions | Used for IBS, UC, pouchitis, etc., under physician supervision | Used for dietary supplementation; different clinical profile |
| Manufacturer | ExeGi Pharma | VSL Pharmaceuticals, Inc. |
Considerations for Choosing a Probiotic
When selecting a probiotic, understanding the number of strains and the specific formulation is critical. For complex gut health issues, a physician-supervised approach with a well-researched, multi-strain formula like Visbiome is often recommended. However, individual responses to probiotics can vary, and factors such as diet, lifestyle, and underlying health conditions all play a role in determining efficacy.
The Role of CFU Count and Storage
In addition to the number of strains, the concentration, measured in Colony Forming Units (CFU), is an important factor. Visbiome offers very high CFU counts, with standard sachets containing 450 billion bacteria and higher potency options available. However, this potency relies on proper handling. Visbiome is a refrigerated product, and maintaining its cold chain during shipping and storage is essential to preserve the viability of the live bacteria. A compromised cold chain can significantly reduce the number of live microorganisms, thereby diminishing the product's effectiveness. This differs from many shelf-stable probiotics that do not require refrigeration.
Conclusion
Visbiome contains 8 specific probiotic strains that make up the highly researched De Simone Formulation. This multi-strain, high-potency blend is intended for the dietary management of specific digestive conditions under a physician's supervision. It is important to distinguish Visbiome from the current VSL#3 product, as Visbiome is the sole carrier of the original, clinically studied De Simone Formulation. By offering a diverse and concentrated mix of beneficial bacteria, Visbiome aims to help restore balance to the gut microbiome and support individuals with complex digestive issues.
Authoritative Link
For more information on the clinical studies regarding the De Simone Formulation and its applications, the National Institutes of Health (NIH) website can provide further scientific context. A Randomized, Placebo-Controlled Trial Assessing the Effect of Visbiome Extra Strength on Systemic Inflammatory Markers, Gut Permeability and the Gut Microbiome in Antiretroviral Therapy-Treated People with HIV.
