The Science Behind Liquorice Safety: Glycyrrhizin
Glycyrrhizin, derived from the Glycyrrhiza glabra root, is responsible for liquorice's sweet flavor and potential health concerns. This compound can interfere with an enzyme that regulates cortisol, leading to elevated cortisol levels. This hormonal effect can cause the body to retain sodium and lose potassium, resulting in pseudoaldosteronism, which can be dangerous, especially for individuals with existing health issues.
Official Daily Recommendations
Health authorities provide varying guidance on safe glycyrrhizin intake:
- World Health Organization (WHO): Suggests healthy adults consume no more than 100 mg of glycyrrhizin daily. This is roughly equivalent to 60–70 grams of traditional liquorice candy, though glycyrrhizin content varies by product.
- Food and Drug Administration (FDA): Warns that for individuals over 40, eating just 2 ounces (about 57 grams) of black liquorice daily for at least two weeks could cause irregular heart rhythms.
- Anses (French Agency): Recommends a stricter limit of 10 mg of glycyrrhizin per day.
Who Should Avoid or Limit Liquorice?
Certain individuals are at higher risk from glycyrrhizin's effects:
- Pregnant Women.
- Individuals with Heart Conditions.
- People with High Blood Pressure.
- Those with Low Potassium Levels.
- People with Kidney or Liver Disease.
- People on Certain Medications.
Real Liquorice vs. Anise-Flavored Products
Many candies labeled "licorice" use anise oil for flavoring instead of real liquorice root extract. Anise oil does not contain glycyrrhizin. Always check ingredient lists for "licorice extract" or "glycyrrhizic acid".
Comparison Table: Real Liquorice vs. Anise-Flavored
| Feature | Real Liquorice (e.g., traditional black liquorice) | Anise-Flavored Candy (e.g., red licorice) |
|---|---|---|
| Contains Glycyrrhizin? | Yes | No |
| Health Risks | Potential for raised blood pressure, low potassium, and heart issues with excessive intake. | Generally low risk. |
| Impact on Medications | Can interfere with blood pressure medications, diuretics, and corticosteroids. | Does not have the same known interactions. |
| Taste Profile | Distinct sweetness from the root. | Mild, more sugary flavor with hints of anise. |
| Product Labeling | Must list "licorice extract" or "glycyrrhizic acid". | May be labeled as "artificially flavored." |
Deglycyrrhizinated Liquorice (DGL)
DGL has most glycyrrhizin removed, making it safer for regular use. It is often used as a supplement.
Recognizing the Signs of Overconsumption
Symptoms of excessive real liquorice consumption can include:
- Fatigue and weakness
- Headache
- Swelling
- Irregular heartbeat
Consult a healthcare provider if you experience these symptoms and consume liquorice regularly.
Conclusion: A Balanced Approach to Liquorice
Moderate and occasional liquorice consumption below the WHO's 100 mg glycyrrhizin limit is generally safe for most healthy adults. Those with health conditions or who are pregnant should be cautious or avoid real liquorice. Check labels to distinguish between real liquorice and anise-flavored options. Consult a healthcare professional with concerns or before using liquorice supplements. High intake can lead to complications.