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Is Disodium Phosphate Harmful to Humans?

4 min read

According to the U.S. Food and Drug Administration (FDA), disodium phosphate is generally recognized as safe (GRAS) when used in moderation as a food additive. However, this designation doesn't tell the whole story, leaving many to question: is disodium phosphate harmful to humans?

Quick Summary

This summary explores the safety of disodium phosphate, explaining its function as a food additive and detailing its potential health risks, particularly for individuals with kidney or heart conditions, while noting its GRAS status when used within regulated limits.

Key Points

  • Generally Recognized as Safe (GRAS): Disodium phosphate is considered safe for the general population when consumed within regulated limits as a food additive.

  • Risk for Kidney Disease Individuals with chronic kidney disease should be cautious, as their bodies may not effectively process excess phosphorus, potentially leading to harmful levels in the blood.

  • Increased Risk from Processed Foods Inorganic phosphates like DSP are more easily absorbed than natural phosphates; a diet high in processed foods can lead to excessive phosphate consumption.

  • Cardiovascular Health Some studies suggest a link between high phosphate levels and an increased risk of cardiovascular disease, including arterial calcification.

  • Read Labels Consumers, especially those with health concerns, can manage their intake by reading ingredient labels and reducing consumption of processed foods containing phosphate additives.

  • Moderation is Key The health concerns primarily relate to high, consistent intake, emphasizing the importance of moderation in consuming processed foods.

In This Article

Understanding Disodium Phosphate

Disodium phosphate (DSP) is a salt made from sodium and phosphorus. It's a common food additive used for a variety of purposes in packaged and processed foods, cosmetics, and medications. In the food industry, DSP serves multiple functions, including acting as an emulsifier, a stabilizer, a preservative, and a pH regulator. It helps keep fats and water from separating in dairy products like cheese and milk, maintains the texture of processed meats, and extends the shelf life of canned goods. It is a highly soluble, white, crystalline powder that can also be used as a leavening agent in baked goods and an anti-caking agent in powdered foods.

The Role of Phosphates in Processed Foods

To understand whether disodium phosphate is harmful, it's essential to recognize the difference between natural and inorganic phosphates. Natural phosphates occur in foods like legumes, nuts, and meats and are not fully absorbed by the body. Inorganic phosphates, such as DSP, are added during food processing and are almost completely absorbed. As a result, consuming a diet rich in processed foods can significantly increase your overall phosphate intake.

General Safety and FDA Guidelines

Regulatory bodies like the FDA and the European Food Safety Authority (EFSA) have approved disodium phosphate for use as a food additive, classifying it as GRAS. This classification is based on the premise that it is used within certain regulated limits, and for most healthy individuals, moderate consumption is not harmful. Normal, healthy kidneys are efficient at filtering out excess phosphorus from the body, preventing it from accumulating to toxic levels.

Potential Health Risks of Excessive Phosphate Intake

While moderate intake is considered safe, excessive consumption of inorganic phosphates, especially from a diet high in processed foods, can pose health risks. This is of particular concern for certain vulnerable populations.

Kidney Health Concerns

Individuals with kidney disease are at the highest risk from excessive phosphate intake. Healthy kidneys filter out excess phosphorus, but damaged kidneys cannot perform this function as effectively. This can lead to a condition called hyperphosphatemia, an abnormally high level of phosphate in the blood. Studies show a strong link between elevated serum phosphate and increased mortality in patients with advanced chronic kidney disease. A high phosphate diet can also put a strain on even healthy kidneys, potentially leading to long-term issues.

Cardiovascular Risks

Research suggests a correlation between high-normal serum phosphate concentrations and an increased risk of cardiovascular events and mortality, even in the general population. Excessive phosphate levels can cause vascular damage, including endothelial dysfunction and arterial calcification, which can contribute to heart disease. The processed foods containing DSP are often high in calories and sodium, which are also known risk factors for heart disease.

Other Potential Side Effects

Though less common with normal dietary consumption, higher medicinal doses of sodium phosphate (a related compound) have been associated with various side effects. These can include gastrointestinal issues like nausea and diarrhea, as well as electrolyte imbalances. Individuals who are pregnant, breastfeeding, or have certain cardiovascular or gastrointestinal conditions are advised to consult a healthcare professional before consuming products containing significant amounts of phosphates.

Comparison: Natural vs. Inorganic Phosphates

To make informed dietary choices, it's helpful to understand how phosphates from different sources are absorbed and affect the body.

Feature Naturally Occurring Phosphate Inorganic Food Additive (like DSP)
Source Whole foods such as legumes, nuts, seeds, meat, and dairy. Synthetically produced from phosphate rock.
Absorption Rate Incompletely absorbed by the body (estimated 40–60% absorption). Nearly completely absorbed by the body (estimated 90–100% absorption).
Dietary Impact Part of a balanced diet; restricting natural sources could lead to nutrient deficiencies. Contributes to a higher overall dietary phosphate load, particularly in processed food-heavy diets.
Health Concerns Generally safe for most people; minimal risk of overconsumption from whole foods. Risk associated with excessive intake, especially for those with pre-existing conditions like kidney disease.

How to Reduce Dietary Phosphate Intake

For those concerned about their phosphate intake, especially if you have a kidney or heart condition, reducing your consumption of processed foods is the most effective strategy. This means limiting your intake of the following:

  • Processed meats (sausages, hot dogs, deli meats)
  • Processed cheeses
  • Fast food and pre-packaged meals
  • Certain baked goods and desserts
  • Some instant pastas, sauces, and dry mixes

Choosing fresh, whole foods is the best way to control your phosphate intake. When you do buy packaged goods, always read the ingredients label. Look for terms like "disodium phosphate," "sodium phosphate," "phosphoric acid," and other similar compounds. Opt for brands that don't use phosphate additives, which are often specified on the packaging.

Conclusion: Navigating Disodium Phosphate

The question of whether is disodium phosphate harmful isn't a simple 'yes' or 'no.' For the majority of the healthy population, moderate consumption of products containing disodium phosphate is considered safe and has been approved by major regulatory bodies. The primary risks are associated with high, chronic intake, particularly for individuals with pre-existing conditions affecting the kidneys or heart. Since the inorganic phosphates in processed foods are more readily absorbed than natural phosphates, a diet heavy in processed goods can lead to a significant phosphate load. Making informed choices by prioritizing fresh, whole foods and checking ingredient lists on packaged items are the most effective ways to manage your phosphate intake and protect your long-term health.

For more information, read the FDA's Select Committee on GRAS Substances (SCOGS) report on Sodium Phosphates.

Frequently Asked Questions

Disodium phosphate is a food additive used as an emulsifier to blend ingredients like oil and water, a stabilizer to maintain texture, a preservative to extend shelf life, and a pH regulator to control acidity.

Sodium phosphate is an umbrella term for various combinations of sodium and phosphate, while disodium phosphate is a specific type of sodium phosphate with two sodium ions.

Individuals with kidney disease, heart conditions, or those who are pregnant or breastfeeding should be cautious with their intake and consult a doctor. High doses can also be risky for people with certain gastrointestinal conditions.

You can check the ingredients list on the food packaging. If it's a food additive, it will be listed as 'disodium phosphate' or its E number, E339(ii) in Europe.

No, phosphates found naturally in whole foods like nuts and legumes are not fully absorbed by the body and are part of a healthy diet. The primary concern is with the highly absorbable inorganic phosphates added to processed foods.

While rare, it is possible for some individuals to have a unique allergic reaction to any ingredient, including disodium phosphate. If you experience discomfort, discontinue use and consult a doctor.

For most healthy individuals, disodium phosphate does not build up in the body because healthy kidneys are very efficient at filtering out excess phosphorus.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.