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Is Pepsi Zero Sugar safe to drink? Here's what the science says

4 min read

According to a 2025 Healthline report, studies on the long-term effects of artificial sweeteners found in diet and zero-sugar sodas like Pepsi Zero Sugar are mixed, with research both raising concerns and confirming safety depending on the study. This has left many consumers wondering if their calorie-free choice is truly a healthier option.

Quick Summary

The safety of Pepsi Zero Sugar hinges on its artificial sweeteners, aspartame and acesulfame potassium, which have conflicting research on their long-term health effects. While regulatory bodies like the FDA affirm their safety in moderation, some studies link these additives to potential issues concerning metabolic health, gut bacteria, and weight gain.

Key Points

  • FDA Approval: The artificial sweeteners in Pepsi Zero Sugar, aspartame and acesulfame potassium, are approved by the FDA as safe for consumption within acceptable daily limits.

  • Conflicting Research: Long-term observational studies on artificial sweeteners have produced mixed results, with some suggesting links to metabolic issues and others finding no significant adverse effects.

  • Not Nutritious: Pepsi Zero Sugar is calorie-free but offers no nutritional value, making alternatives like water or unsweetened tea a healthier choice for hydration.

  • Dental Risks: The acids in diet sodas, including Pepsi Zero Sugar, can erode tooth enamel over time, regardless of the sugar content.

  • Moderation is Key: Experts generally agree that consuming zero-sugar soda in moderation is safe for most individuals, but high intake over the long term remains a topic of debate.

In This Article

Understanding the Ingredients: Aspartame and Acesulfame Potassium

Pepsi Zero Sugar is sweetened with a combination of two artificial sweeteners: aspartame and acesulfame potassium (Ace-K). Unlike regular Pepsi, which contains high-fructose corn syrup, Pepsi Zero Sugar contains no sugar and zero calories. The use of multiple sweeteners is a common industry practice to create a taste profile that more closely mimics sugar, as seen in other products like Coca-Cola Zero Sugar.

Aspartame: The Long-Standing Sweetener

Aspartame is an artificial, non-saccharide sweetener that is 200 times sweeter than sucrose (table sugar). It was approved by the U.S. Food and Drug Administration (FDA) in 1974 and has been one of the most widely studied food additives. Despite extensive research and regulatory approval, concerns about its safety have persisted for decades, particularly surrounding a potential link to cancer. The International Agency for Research on Cancer (IARC), a part of the World Health Organization (WHO), classified aspartame as a possible carcinogen in 2023, though this was based on 'limited evidence,' and the FDA has disagreed with this classification.

Acesulfame Potassium (Ace-K): The Calorie-Free Partner

Acesulfame potassium, or Ace-K, is another calorie-free sweetener that is often used in combination with other artificial sweeteners. It is approved for use in food and beverages in the United States and other countries. Some early studies, particularly in rodents, have raised questions about its long-term effects, including potential impacts on the gut microbiome. However, regulatory bodies have set acceptable daily intake (ADI) levels, which are generally well above the amount a person would typically consume.

Potential Health Concerns Linked to Artificial Sweeteners

While regulatory bodies maintain that these sweeteners are safe for moderate consumption, some research has explored potential negative health effects, though findings are often conflicting and require further investigation.

  • Metabolic Effects and Diabetes Risk: Some observational studies have shown an association between diet soda consumption and an increased risk of type 2 diabetes and metabolic syndrome. However, it is difficult to determine if the artificial sweeteners directly cause these issues or if people who already have metabolic risk factors are more likely to choose diet sodas.
  • Weight Management: The idea that drinking diet soda helps with weight loss has been challenged. Some studies suggest that the intense sweetness can confuse the brain, leading to increased cravings for high-calorie foods. Other research, however, shows that swapping sugary drinks for diet alternatives can lead to weight loss. The impact appears to be mixed and may depend on individual factors and overall dietary patterns.
  • Gut Health: Emerging research suggests artificial sweeteners may impact the gut microbiome, which can have downstream effects on metabolic health and the immune system. However, large-scale human studies are still needed to draw firm conclusions.
  • Dental Health: Although sugar-free, diet sodas are still highly acidic due to ingredients like phosphoric acid and citric acid. This acidity can erode tooth enamel over time, increasing the risk of dental problems, though not cavities.

Pepsi Zero Sugar vs. Diet Pepsi

Consumers often wonder about the difference between Pepsi Zero Sugar and Diet Pepsi beyond the taste. The formulations are distinct, leading to differences in flavor profile and, in some cases, caffeine content.

Feature Pepsi Zero Sugar Diet Pepsi
Sweeteners Aspartame and Acesulfame Potassium Aspartame only (historically)
Flavor Profile Designed to taste more like regular Pepsi, with a richer, bolder flavor A lighter, distinct diet soda flavor
Marketing Target Primarily marketed to younger audiences who avoid the word "diet" A long-standing diet soda brand
Caffeine Content Contains a higher caffeine content than Diet Pepsi Contains less caffeine compared to Pepsi Zero Sugar

Making an Informed Decision

The safety of Pepsi Zero Sugar, much like other artificially sweetened beverages, is not a simple yes-or-no answer. The consensus from regulatory bodies like the FDA is that the sweeteners are safe for human consumption within the recommended acceptable daily intake (ADI). For most people, occasional or moderate consumption is unlikely to pose a significant health risk. However, the long-term, high-volume consumption of diet sodas is where potential concerns arise, particularly concerning weight management, metabolic syndrome, and gut health, as indicated by some studies.

It is crucial to remember that Pepsi Zero Sugar offers no nutritional benefits. As a Harvard Health blog post advises, it's better to quench thirst with healthier alternatives like water, seltzer, or unsweetened tea. A healthy, balanced diet overall is more important for long-term health than focusing on a single ingredient or product.

Conclusion: Moderation is Key

For most people, enjoying a Pepsi Zero Sugar in moderation is not a significant health risk, based on current regulatory standards and extensive research. The controversy surrounding artificial sweeteners, like aspartame and acesulfame potassium, stems from conflicting observational studies and a need for more robust, long-term human trials. The most informed approach is to prioritize nutrient-dense beverages like water and unsweetened tea, reserving sodas—even zero-sugar ones—as an occasional indulgence rather than a staple. This helps maintain a balanced diet and reduces the intake of non-nutritive additives. As always, those with specific health conditions like diabetes or phenylketonuria should consult their healthcare provider for personalized advice. For general health advice, resources like the CDC provide guidance on making healthier beverage choices.

Alternatives to Consider

If you're looking to reduce your intake of artificially sweetened beverages, here are some healthier alternatives to consider:

  • Plain or Flavored Water: The ultimate choice for hydration. Add slices of lemon, cucumber, or berries for a flavor boost.
  • Seltzer or Sparkling Water: Provides the satisfying fizz of soda without any calories or artificial sweeteners.
  • Herbal Tea: Unsweetened teas, hot or iced, come in a variety of flavors and can offer a refreshing break.
  • Fruit-Infused Water: Create your own custom flavors by adding fresh or frozen fruit and herbs like mint.

Frequently Asked Questions

Pepsi Zero Sugar is calorie and sugar-free, making it a better option for managing blood sugar and calorie intake than regular Pepsi. However, it is not a nutritious choice and moderation is still recommended.

For most people with diabetes, Pepsi Zero Sugar does not cause blood sugar spikes. However, some studies suggest that artificial sweeteners may affect insulin sensitivity or gut health over time, so consumption should be moderate and discussed with a healthcare provider.

Yes, Pepsi Zero Sugar is sweetened with a blend of artificial sweeteners, including aspartame and acesulfame potassium (Ace-K).

Research on diet soda and weight gain is conflicting. Some studies suggest a link, possibly due to increased cravings for sweets, while others show no such association or even a benefit when replacing sugary drinks.

The main differences are in the sweetener blend and flavor profile. Pepsi Zero Sugar uses both aspartame and acesulfame potassium for a bolder taste, while Diet Pepsi has a slightly different flavor and historically used only aspartame.

Regulatory bodies like the FDA consider the sweeteners safe. The World Health Organization's IARC classified aspartame as a 'possible' carcinogen based on 'limited evidence,' but noted that typical daily intake is well below levels of concern.

Yes. Like regular sodas, Pepsi Zero Sugar is highly acidic due to ingredients like phosphoric acid. This acid can erode tooth enamel over time, increasing the risk of dental damage.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.