Is Skipjack Tuna Inflammatory? The Truth About Omega-3s and Your Health

October 28, 2025 •

3 min read

Scientific studies have shown that components of skipjack tuna possess anti-inflammatory effects. Far from being inflammatory, the consensus is that is skipjack tuna inflammatory is a myth, largely due to its rich content of anti-inflammatory omega-3 fatty acids.

Quick Summary

Skipjack tuna contains anti-inflammatory omega-3 fatty acids (EPA and DHA), with research confirming its anti-inflammatory effects through various biological mechanisms. It is a nutritious lean protein source, but moderate consumption is recommended due to mercury and purine considerations, especially when compared to other tuna varieties.

Key Points

Omega-3 powerhouse: Skipjack tuna is a rich source of anti-inflammatory omega-3 fatty acids, EPA and DHA.
Scientific backing: Research confirms that compounds within skipjack, like peptides from its dark muscle and oil from its eyeballs, exhibit anti-inflammatory effects.
Low mercury choice: As a smaller species, skipjack has a lower mercury content than larger tuna varieties like albacore, making it a safer option for more frequent consumption.
Moderate purine levels: While containing some purines that can affect gout, boiling canned tuna and following portion recommendations can help manage intake.
Dietary powerhouse: In addition to omega-3s, skipjack is a lean protein source packed with Vitamin B12, Vitamin D, and Selenium, supporting heart and brain health.
Best choice for canned tuna: Opt for water-packed, low-sodium canned light tuna (typically skipjack) for the healthiest option.

The Anti-Inflammatory Power of Omega-3 Fatty Acids

Skipjack tuna is a powerful source of omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). These polyunsaturated fats are critical for health, playing a significant role in managing inflammation pathways within the body. Omega-3s work to counteract pro-inflammatory processes, supporting everything from cardiovascular and neurological health to reducing the risk of chronic inflammatory diseases. Our bodies cannot produce these essential fats in sufficient quantities, making dietary intake from sources like skipjack tuna vital.

Scientific Evidence for Skipjack's Anti-Inflammatory Properties

Beyond general omega-3 content, specific research has delved into the anti-inflammatory effects of skipjack tuna components. For example, studies have found that oil from the eyeball of skipjack tuna can inhibit pro-inflammatory cytokines in cell models, suggesting significant anti-inflammatory therapeutic potential. Similarly, dark muscle hydrolysates from skipjack tuna have been shown to have potent anti-inflammatory and anti-allergic effects in laboratory settings, with researchers linking this activity to the fish's natural antioxidant capacity. These findings support the idea that different parts of the fish contain compounds that can actively combat inflammation at a cellular level.

Mercury and Purines: Addressing Potential Concerns

While the tuna itself is not inflammatory, potential health concerns related to mercury and purines require consideration for safe consumption. As a smaller and shorter-lived tuna species, skipjack has a significantly lower mercury content compared to larger varieties like albacore or bigeye tuna. Canned light tuna, which is often skipjack, is considered a lower-mercury option. However, chronic, excessive consumption of any fish can lead to mercury accumulation over time, so moderation is key. For individuals with gout, it's also important to note that tuna contains moderate to high levels of purines, which can affect uric acid levels and potentially trigger attacks. Opting for canned over fresh and using cooking methods like boiling can help reduce purine content.

Nutritional Comparison: Skipjack vs. Albacore Tuna

To better understand how skipjack stacks up against other popular tuna, here is a comparison with albacore tuna, often known as "white" tuna.


Feature	Skipjack (Light Tuna)	Albacore (White Tuna)
Mercury Content	Lower mean concentration of 0.126 ppm in canned light tuna.	Higher mean concentration of 0.350 ppm in canned albacore tuna.
Omega-3s (EPA+DHA)	Good Source: Around 0.2–0.3 grams per 3-ounce serving in canned light tuna.	Higher Source: Around 0.8–1.0 grams per 3-ounce serving in canned albacore.
Fat Content	Leaner protein source.	Higher in fat, including beneficial omega-3s.
Flavor	Richer, stronger flavor.	Milder flavor, firmer texture.
Safe Consumption	Recommended 2-3 servings per week.	Recommended limit of one 4-ounce serving per week.

How to Incorporate Skipjack Tuna into an Anti-Inflammatory Diet

Integrating skipjack tuna into your meals can be a delicious and easy way to support an anti-inflammatory diet. Consider these tips:

Choose Wisely: When buying canned tuna, look for varieties packed in water and with "no salt added" to control sodium intake. Some brands even test for mercury levels to ensure they are well below the FDA's action limit.
Meal Ideas: Skipjack is incredibly versatile. Create a Mediterranean tuna salad bowl with chickpeas, olives, and fresh vegetables. For a heartier option, make tuna patties or mix flaked tuna into a quinoa salad. For fresh or frozen skipjack, a simple pan-sear with herbs and lemon is a great, flavorful choice.

Conclusion

Far from being inflammatory, skipjack tuna provides significant anti-inflammatory benefits, primarily from its rich omega-3 fatty acid content. Specific research further highlights the anti-inflammatory potential of its bioactive compounds. For most people, including skipjack in a balanced diet is a healthy choice, especially given its lower mercury levels compared to larger tuna species. By following recommended serving sizes and opting for lower-mercury, low-sodium varieties, you can harness its nutritional power while minimizing risks. As with any food, moderation is key to maximizing its benefits and ensuring a well-rounded, healthy eating plan.

Frequently Asked Questions

Canned light tuna is typically made from skipjack tuna, though it can also sometimes contain yellowfin tuna. Both are smaller species with lower mercury levels than albacore tuna.

Both are nutritious, but skipjack (canned light) is often considered the better choice for regular consumption due to its significantly lower mercury content. Albacore has higher omega-3s but also much higher mercury levels.

The FDA recommends that adults can safely eat two to three servings (around 4 ounces per serving) of canned light tuna (skipjack) per week. Pregnant women should follow more specific guidelines, typically also limiting themselves to the "best choice" fish list.

Yes, tuna contains moderate to high levels of purines, which can increase uric acid levels and potentially trigger a gout attack in susceptible individuals. Fresh tuna has higher purines than canned, and boiling can help reduce the content.

The primary anti-inflammatory compounds in skipjack tuna are the omega-3 fatty acids, EPA and DHA. Research has also identified other bioactive peptides and compounds with anti-inflammatory properties, particularly in the dark muscle and oil.

Canned tuna packed in water is often considered the healthier option as it contains fewer calories and less fat compared to oil-packed varieties. Choosing "no salt added" is also recommended for better sodium control.

Besides its anti-inflammatory properties, skipjack tuna is an excellent source of lean protein for muscle repair, supports brain function, boosts the immune system with Vitamin B12 and Selenium, and contributes to weight management.