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Is It Better to Take Magnesium Glycinate or Regular Magnesium?

5 min read

According to the National Institutes of Health, nearly half of the U.S. population has inadequate magnesium intake from their diet alone. This widespread deficiency has led to a boom in magnesium supplements, but the options are not all equal, especially when comparing magnesium glycinate to more 'regular' forms like magnesium oxide.

Quick Summary

This guide compares magnesium glycinate and other common forms to help you select the right supplement. We examine key differences in absorption, bioavailability, and side effects. Learn which type is best for specific health goals like sleep, anxiety, or digestive support.

Key Points

  • Superior Bioavailability: Magnesium glycinate is a chelated, organic form with significantly higher absorption rates compared to inorganic 'regular' forms like magnesium oxide.

  • Specific Health Benefits: Glycinate is ideal for promoting relaxation, reducing anxiety, and improving sleep quality, while other forms like oxide or citrate serve different purposes.

  • Gentle on Digestion: Unlike magnesium citrate or oxide which can cause laxative effects, magnesium glycinate is very gentle on the stomach and minimizes digestive upset.

  • Consider Your Goal: Choose based on your needs—glycinate for sleep and stress, citrate for constipation, and avoid oxide for systemic deficiency due to its poor absorption.

  • Prioritize Quality: Always select supplements from reputable brands that undergo third-party testing to ensure purity and potency.

In This Article

Understanding the 'Regular Magnesium' Label

When you see a supplement simply labeled as "magnesium," it most often contains an inorganic salt, typically magnesium oxide. While magnesium oxide has a very high concentration of elemental magnesium by weight, its bioavailability, or the amount your body can actually absorb and use, is notoriously poor—as low as 4% in some studies. This form is often used as a laxative due to its ability to pull water into the intestines, which can cause digestive issues like diarrhea. Therefore, for most people looking to address a deficiency or gain systemic health benefits, magnesium oxide is not the optimal choice.

The Superiority of Magnesium Glycinate

Magnesium glycinate, by contrast, is a chelated form of magnesium, meaning it's bound to the amino acid glycine. This special bond makes it highly bioavailable and far easier on the digestive system than magnesium oxide. Glycine itself is a calming neurotransmitter, which provides added benefits that synergize with magnesium's effects.

Benefits Unique to Magnesium Glycinate

  • Enhanced Relaxation and Sleep: The combination of magnesium and glycine provides a powerful calming effect on the nervous system. Glycine acts as an inhibitory neurotransmitter, which helps to promote sleep and reduce feelings of anxiety.
  • Superior Absorption: The chelated nature of magnesium glycinate protects it from interacting with other substances in the gut, ensuring a higher percentage of the mineral is absorbed and utilized by the body.
  • Gentle on the Stomach: For individuals with sensitive digestion, magnesium glycinate is the go-to option. It is significantly less likely to cause the laxative side effects associated with other forms like citrate or oxide.

Comparing Magnesium Glycinate to Other Forms

To make an informed decision, it's helpful to compare magnesium glycinate not only to the cheaper 'regular' forms but also to other popular options. Here is a comparison of some of the most common magnesium supplements:

Aspect Magnesium Glycinate Magnesium Citrate Magnesium Oxide
Absorption (Bioavailability) High - Excellent, highly absorbable Moderate to High - Well-absorbed but with a laxative effect Low - Very poorly absorbed
Primary Benefits Relaxation, anxiety relief, improved sleep quality, muscle recovery Constipation relief, replenishing electrolytes, general magnesium support Indigestion and heartburn relief, occasional constipation
Digestive Tolerance Very gentle on the stomach; minimal digestive upset Can have a strong laxative effect at higher doses High risk of digestive upset, including diarrhea and cramping
Best For Individuals seeking to improve sleep, reduce stress, and minimize stomach irritation People needing a reliable laxative or quick replenishment after exercise Those with occasional heartburn or in need of an affordable, but poorly absorbed, option

Which Form Should You Choose?

Your choice of magnesium supplement should be based on your specific health goals.

  • For sleep and stress relief: Magnesium glycinate is the clear winner. Its combination of high bioavailability and calming properties makes it the best option for promoting relaxation and restorative sleep.
  • For constipation: Magnesium citrate is highly effective as a natural, osmotic laxative. However, if your goal is systemic absorption, the laxative effect can be counterproductive.
  • For general health: The term "regular magnesium" typically refers to oxide, which is inexpensive but poorly absorbed. For general supplementation and daily intake, better-absorbed forms like glycinate or citrate offer more value per dose. A blend containing multiple well-absorbed forms can also be a good option for broad support.

The Importance of Quality

Regardless of the form you choose, ensure you buy from a reputable brand that provides third-party testing for purity and potency. Always start with a lower dose to assess your tolerance, especially if you are new to magnesium supplements.

Conclusion: Making the Right Choice for Your Wellness

When comparing magnesium glycinate to regular magnesium (often magnesium oxide), the differences in absorption, purpose, and side effects are significant. Magnesium glycinate offers superior bioavailability, is gentle on the stomach, and provides targeted benefits for relaxation and sleep. While regular magnesium is cheaper and effective for certain digestive issues, its poor absorption makes it unsuitable for effectively addressing a systemic deficiency.

For those prioritizing improved sleep, reduced anxiety, or maximum absorption without digestive upset, magnesium glycinate is the superior choice. However, for occasional constipation relief, magnesium citrate may be a more appropriate option. Always consult a healthcare professional to determine the best form for your individual needs and to ensure it won't interact with other medications.

Ultimately, understanding the unique properties of each form empowers you to choose a supplement that most effectively supports your personal health and wellness goals. With its high absorbability and added calming benefits, magnesium glycinate is an investment in your health that delivers noticeable results for sleep, stress, and overall relaxation.

Frequently Asked Questions

  • What is the main difference between magnesium glycinate and other magnesium forms? The main difference lies in its high bioavailability and minimal laxative effect, thanks to its chelation with the amino acid glycine.
  • Is magnesium glycinate better than magnesium citrate? It depends on your goal. Magnesium glycinate is better for relaxation, sleep, and anxiety relief without causing digestive upset. Magnesium citrate is better as a laxative for constipation relief.
  • How long does it take for magnesium glycinate to work? While individual results vary, some people notice improved relaxation and sleep within a week of consistent use. For addressing a deficiency, it may take longer.
  • Can magnesium glycinate help with anxiety? Yes, magnesium glycinate is one of the most recommended forms for anxiety due to the calming effects of both magnesium and its amino acid component, glycine.
  • What is the downside of taking magnesium oxide? The main downside is its poor bioavailability, meaning a very small percentage is actually absorbed by the body. This is why it often causes a laxative effect.
  • Is it safe to take magnesium glycinate daily? Yes, magnesium glycinate is generally considered one of the safest forms for daily and long-term supplementation due to its gentleness on the stomach.
  • Should I take magnesium glycinate with food? While you can take it with or without food, taking it with a meal may further enhance absorption and can be gentler on a sensitive stomach.

Frequently Asked Questions

The main difference is bioavailability. Magnesium glycinate is a chelated, organic form that is highly absorbable and gentle on the stomach. 'Regular' magnesium, often magnesium oxide, is an inorganic salt with very low absorption, and is primarily used for its laxative effect.

Magnesium glycinate is widely recommended as the best form for anxiety and sleep. It is bound to the calming amino acid glycine, which helps promote relaxation and reduces stress without causing stomach upset.

Magnesium glycinate is not typically used for constipation relief. For that purpose, magnesium citrate is more effective due to its osmotic (laxative) properties.

Both are considered highly bioavailable, but magnesium glycinate is generally seen as gentler on the digestive system. Magnesium citrate's effectiveness for digestion can also result in a laxative effect, which may hinder systemic absorption for some individuals.

Magnesium glycinate is more expensive because it is a chelated, premium formulation with a higher bioavailability. Magnesium oxide is cheaper to produce but is poorly absorbed by the body.

Your choice should depend on your health goals. If you need sleep or anxiety relief, choose glycinate. If you need constipation relief, choose citrate. For systemic deficiency, avoid the low-absorption oxide. Consulting a healthcare provider for personalized advice is also recommended.

The side effects can vary by form. Magnesium oxide and high doses of citrate can cause diarrhea and digestive upset. Magnesium glycinate is generally well-tolerated with minimal side effects.

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.