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What are the side effects of drinking clover?

4 min read

While often used in traditional medicine, red clover contains phytoestrogens that can mimic the hormone estrogen in the body, leading to potential side effects. It is important to understand the risks before incorporating clover into your diet, especially when consumed in concentrated forms like tea or supplements.

Quick Summary

Red clover, a common herbal remedy, may cause mild to severe side effects due to its phytoestrogen content, including nausea, headaches, and vaginal spotting. High-risk groups, such as pregnant or breastfeeding women, and those with hormone-sensitive conditions, should avoid its use. Additionally, it can interact with certain medications, including blood thinners.

Key Points

  • Hormonal Disruption: Red clover's phytoestrogens can act like estrogen in the body, potentially causing hormonal changes like vaginal spotting or breast tenderness.

  • Risk of Bleeding: Red and white clover can have blood-thinning effects, which increases the risk of bleeding, especially for those on anticoagulant medications or before surgery.

  • Toxicity in Some Species: Moldy sweet clover is toxic due to the presence of dicoumarol, a powerful anticoagulant, while alsike clover is known to cause liver damage in animals.

  • Contraindicated for Sensitive Groups: Pregnant and breastfeeding women, along with those with hormone-sensitive cancers (e.g., breast cancer), should avoid clover due to its estrogenic properties.

  • Medication Interference: Clover can interact with several medications, including tamoxifen, methotrexate, and hormonal contraceptives, potentially altering their effects.

  • Risk of Contamination: Foraging for wild clover is risky due to potential contamination from pesticides or misidentification of species.

In This Article

Common Varieties of Clover and Their Risks

Not all clover is the same, and the risks associated with drinking it vary by species. Red clover (Trifolium pratense) is the most commonly used variety for herbal preparations, but other types, like sweet clover (Melilotus spp.) and alsike clover (Trifolium hybridum), carry unique dangers.

Red Clover (Trifolium pratense)

Red clover is widely recognized for its high concentration of isoflavones, a type of phytoestrogen.

  • Hormonal Effects: The estrogen-like compounds in red clover can cause hormonal fluctuations. For some, this may result in vaginal spotting, prolonged menstrual periods, or breast tenderness.
  • Digestive Issues: Some users have reported experiencing nausea, upset stomach, or bloating after consuming red clover tea or supplements.
  • Headaches and Skin Irritation: Headaches and skin rashes are other potential side effects, although they are considered rare.

Sweet Clover (Melilotus spp.)

Sweet clover is primarily a concern when it becomes moldy. Under damp conditions, a substance called coumarin converts into dicoumarol, a potent anticoagulant.

  • Increased Bleeding Risk: Dicoumarol is a blood-thinning agent that can lead to severe internal bleeding. While this is a well-documented risk in livestock, particularly from moldy hay, it underscores the importance of sourcing herbal products from trusted, safe suppliers.
  • Unsafe for Humans: Because of this toxicity risk, spoiled sweet clover is not safe for human consumption in tea or other forms.

Alsike Clover (Trifolium hybridum)

Alsike clover is primarily a known toxin for animals, especially horses.

  • Liver Damage: Long-term consumption of Alsike clover has been linked to liver damage and liver failure in livestock.
  • Photosensitivity: It can also cause photosensitization, a condition where the skin becomes highly sensitive to sunlight, leading to inflammation and lesions.

Who Should Avoid Drinking Clover?

Due to its various active compounds and potential side effects, certain individuals should avoid or be extremely cautious when consuming clover.

  • Pregnant and Breastfeeding Women: Because red clover contains phytoestrogens that can affect hormone levels, it is not recommended during pregnancy or breastfeeding.
  • Individuals with Hormone-Sensitive Conditions: People with conditions like breast cancer, ovarian cancer, uterine cancer, endometriosis, or uterine fibroids should not use red clover, as its estrogenic effects could worsen these issues.
  • Those on Blood-Thinning Medication: Red clover has mild blood-thinning properties and can increase the risk of bleeding, especially when combined with anticoagulant drugs like warfarin.
  • Individuals Awaiting Surgery: To prevent excessive bleeding, it is advised to stop taking red clover at least two weeks before any scheduled surgery.
  • People with Liver Issues: While primarily a risk in animals from alsike clover, anyone with pre-existing liver conditions should consult a doctor before consuming any type of clover.

Comparison of Clover Varieties

Feature Red Clover (Trifolium pratense) Sweet Clover (Melilotus spp.) Alsike Clover (Trifolium hybridum)
Primary Active Compounds Isoflavones (Phytoestrogens) Coumarin (Converts to dicoumarol in moldy hay) Unknown toxins (Likely from fungal contamination)
Main Health Concern Hormonal effects, mild side effects Severe bleeding risk from dicoumarol Liver damage and photosensitivity (primarily in livestock)
Common Side Effects Nausea, headaches, vaginal spotting Internal bleeding, hemorrhaging Skin photosensitivity, liver failure
Main Caution Hormone-sensitive conditions, pregnancy, medications Ingesting moldy hay; not for human use Highly toxic to horses; avoid consumption

Potential Drug Interactions

Beyond specific pre-existing conditions, drinking clover can pose risks through interactions with various medications. The phytoestrogens in red clover can affect how the liver processes certain drugs, while its blood-thinning properties require extra caution with other medications.

  • Tamoxifen: Red clover may interfere with this breast cancer medication, potentially decreasing its effectiveness.
  • Methotrexate: There have been reports of methotrexate toxicity in patients also taking red clover.
  • Hormonal Birth Control and HRT: The estrogen-like effects of red clover can interfere with hormonal contraception and hormone replacement therapy.
  • Liver-Metabolized Drugs: Red clover can alter the rate at which the liver breaks down various medications, changing their effects and potential side effects.

The Risks of Foraging for Wild Clover

Foraging for wild clover to make tea or other remedies carries additional risks. Besides the potential for misidentification of toxic species, wild plants can be contaminated with harmful substances.

  • Pesticide Contamination: Clover growing in urban or treated areas, such as lawns and parks, may contain pesticides and herbicides that are dangerous if ingested.
  • Incorrect Species: Mistaking one species of clover for another can be dangerous. Sweet clover, for example, is toxic when moldy, and alsike clover is a known hepatotoxin for animals.

Conclusion

While clover is celebrated in some traditional medicine circles, it is crucial to approach its consumption with caution due to the notable side effects and risks, particularly from red clover's phytoestrogen content and the toxic potential of other varieties. Common side effects range from mild digestive upset to more serious issues like hormonal interference and increased bleeding risk. Furthermore, certain populations, including pregnant women and individuals with hormone-sensitive cancers, should avoid it entirely. Before considering drinking clover, consult with a healthcare professional, especially if you are taking other medications or have pre-existing health conditions, to ensure your safety.

Frequently Asked Questions

No, it is recommended to avoid red clover if you are pregnant or breastfeeding. The phytoestrogens it contains can affect hormone balances and may not be safe for you or the baby.

Yes, red clover can interact with several medications, including blood thinners, tamoxifen, and methotrexate. Its phytoestrogen content can also interfere with hormonal contraceptives and HRT.

While alsike clover is known to cause liver damage in animals, especially horses, the risk for humans from typical red clover preparations is generally low. However, individuals with existing liver conditions should exercise caution.

The most common, though rare, side effects reported from red clover include mild issues like nausea, headaches, muscle aches, and vaginal spotting.

No, not all clover is safe. Even if not moldy, species like alsike clover can be toxic, and all varieties, especially red clover, carry potential risks related to their specific chemical compounds.

Yes, if you forage for wild clover, you should be concerned about pesticide and herbicide contamination. Clover growing in treated areas, such as lawns and parks, can absorb these harmful chemicals.

Yes, red clover contains phytoestrogens that can mimic estrogen in the body, potentially leading to hormonal issues. This is why it is not recommended for individuals with hormone-sensitive conditions.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.