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What are the side effects of E220 food additive?

4 min read

According to the European Food Safety Authority (EFSA), E220 and other sulfites could pose a safety concern for people consuming high levels. E220, or sulfur dioxide, is a common preservative, but what are the specific side effects of this E220 food additive for consumers?

Quick Summary

This article explores the potential adverse health effects associated with E220, or sulfur dioxide, primarily affecting those with asthma or sensitivities. It details respiratory, gastrointestinal, and allergic reactions, and highlights its presence in various foods and beverages.

Key Points

  • Respiratory Reactions: Individuals with asthma are most susceptible to E220 side effects, including wheezing, chest tightness, and potential anaphylaxis.

  • Gastrointestinal Issues: High intake of E220 can cause stomach cramps, nausea, and diarrhea in some people.

  • Allergic-Type Symptoms: Sulfite sensitivity can lead to non-IgE mediated reactions like hives, flushing, and skin swelling.

  • Vitamin B1 Destruction: E220 has been shown to destroy thiamine (vitamin B1) content in food.

  • Product Labeling: Food labels are required to declare sulfites (E220-E228) if their concentration exceeds 10 ppm, aiding in avoidance.

  • Found in Common Foods: E220 is a common preservative in dried fruits, wine, beer, and some processed potato products.

  • Regulatory Scrutiny: The European Food Safety Authority (EFSA) has updated safety evaluations, noting potential safety concerns at high intake levels.

In This Article

What is E220 Food Additive?

E220 is the code for sulfur dioxide, a colorless gas with a pungent smell that is widely used as a preservative and antioxidant in the food industry. Its primary function is to prevent food spoilage by inhibiting the growth of bacteria, yeasts, and molds. It also helps prevent browning and maintains the fresh appearance of many food products, which is why it is often used in dried fruits like apricots and raisins. Beyond its use as a gas, related compounds such as sodium or potassium sulfites (E221-E228) also release sulfur dioxide and are used for similar purposes.

Side Effects Primarily Affect Sensitive Individuals

While E220 is considered safe for consumption by most of the general population in small amounts, it is not without risks, especially for those with pre-existing conditions or sensitivities. The most significant concerns revolve around allergic-type reactions and respiratory issues, particularly in people with asthma. A small percentage of asthmatics have a sulfite sensitivity, and for them, ingesting E220 can trigger adverse reactions.

Respiratory Symptoms

For asthmatics and individuals with sulfite sensitivity, respiratory issues are the most common side effects. This is because when consumed, sulfites can release sulfur dioxide gas, which can irritate and constrict the airways.

  • Asthma Attacks: Exposure to E220 can trigger or exacerbate asthma symptoms, including wheezing, chest tightness, and shortness of breath. The severity can vary, from mild to life-threatening bronchoconstriction.
  • Coughing and Wheezing: These symptoms are often the first sign of a reaction in sensitive individuals.
  • Runny Nose (Rhinitis): Non-asthmatic individuals can also experience rhinitis or a stuffy nose from sulfite sensitivity.

Gastrointestinal and Other Allergic-Type Reactions

Beyond respiratory problems, E220 can cause a variety of other symptoms in intolerant or sensitive people. These are often described as pseudoallergic reactions, meaning they mimic allergic responses but do not involve the immune system's IgE antibodies.

  • Gastrointestinal Distress: Large amounts of ingested sulfites have been linked to stomach cramps, nausea, and diarrhea.
  • Skin Reactions: Symptoms like hives (urticaria), flushing, and skin swelling (angioedema) have been reported.
  • Anaphylaxis (Rare): In extremely rare and severe cases, a life-threatening anaphylactic shock can occur, involving a significant drop in blood pressure and circulatory collapse.

Other Potential Health Concerns

Research has explored other potential long-term effects and health concerns related to high sulfite intake, including its impact on nutrient absorption.

  • Vitamin B1 Destruction: Some studies suggest that E220 can destroy vital vitamin B1 (thiamine) in food, potentially wiping out its content in a meal.
  • Calcium Loss: Older animal studies have indicated a possible link between sulfite consumption and increased calcium loss from the body, raising concerns about osteoporosis risk, though more conclusive research is needed.
  • Inflammatory Bowel Disease: Certain bacteria in the gut can feed on sulfur compounds, and some researchers hypothesize a connection between sulfite consumption and inflammatory bowel diseases, though this is also an area of ongoing study.

Comparison of E220 Effects on Asthmatics vs. Non-Asthmatics

Feature Sensitive Asthmatics Non-Asthmatic General Population
Sulfite Reaction Highly probable Less common; typically safe
Primary Symptoms Wheezing, chest tightness, shortness of breath, coughing Potential for gastrointestinal issues (cramps, diarrhea) with high doses
Symptom Severity Can be mild to severe, including anaphylaxis Mild symptoms, if any, usually disappear quickly
Mechanism Inhalation of sulfur dioxide gas and/or low sulfite oxidase enzyme levels Generally no adverse reaction, as most can metabolize sulfites effectively
Risk Factor Significant risk; a known trigger for bronchoconstriction Very low risk for adverse reactions

How to Identify and Avoid E220

Consumers who want to limit or avoid E220 need to be vigilant, as it is used in a wide range of products. Regulations require food labels to declare sulfites if the concentration exceeds 10 parts per million (ppm).

Common Sources of E220

  • Dried Fruit: Preservatives like E220 are used to maintain the vibrant color of items such as dried apricots and golden raisins. Organic dried fruit does not contain added sulfites.
  • Wine: Both naturally occurring and added sulfites are found in wine. Bottles in many regions must declare the presence of sulfites.
  • Processed Foods: Sulfites can be in a wide variety of processed items, including some sauces, juices, and potato products like powdered purées and hash browns.
  • Seafood: Some seafood, particularly shrimp and crabs, may contain sulfites, though labeling is required.

Conclusion

While E220 functions as an effective preservative for many food products, its side effects are a genuine concern, particularly for individuals with asthma or sulfite sensitivities. For this vulnerable group, reactions can range from mild discomfort, such as hives or stomach cramps, to severe respiratory distress or, in very rare cases, anaphylaxis. The destruction of vitamin B1 is another documented effect of E220. By reading labels and understanding which products are likely to contain sulfites, consumers can make more informed choices about their dietary intake and minimize their risk of adverse reactions.

Considerations for Individuals

  • For Asthmatics: It is highly recommended to speak with a doctor or allergist about sulfite sensitivity. Avoiding products with E220 and other sulfite additives is a key preventive measure.
  • For the General Public: For most people, E220 in regulated amounts poses little to no threat. However, being aware of the potential for gastrointestinal upset from high consumption is still prudent.
  • Regulatory Efforts: Due to increasing consumer awareness and recent safety evaluations, organizations like the EFSA have been re-evaluating and tightening acceptable daily intake levels for sulfites.

For more detailed information on sulfite sensitivity and diagnosis, consult an allergist or visit a reputable health resource like the Cleveland Clinic's page on Sulfite Allergy & Sensitivity.

Frequently Asked Questions

E220 is the European code for sulfur dioxide, a colorless gas used as a preservative and antioxidant in food processing to prevent bacterial growth and maintain food color.

People with asthma and individuals with sulfite sensitivity are most at risk, as E220 can trigger severe respiratory reactions like bronchoconstriction.

Yes, for sensitive individuals with asthma, E220 can trigger or worsen asthma symptoms, including wheezing, chest tightness, and coughing.

While a true IgE allergy is rare, E220 can cause pseudoallergic reactions that include skin rashes, hives, swelling, and gastrointestinal distress.

E220 is frequently found in dried fruits (e.g., apricots, raisins), wine, beer, fruit juices, and some processed potato products.

To avoid E220, check food labels for 'sulfur dioxide', 'contains sulfites', or codes E220-E228. Choosing organic dried fruits and being mindful of wine and processed food contents can help.

Yes, some studies indicate that E220 can deplete vitamin B1 (thiamine) content in certain foods.

E220 is regulated rather than banned in most countries. However, due to past reports of severe reactions, its use on raw produce sold fresh to the public was banned by the FDA in the US.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.