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What are the side effects of intermittent fasting?

5 min read

According to a study published in Cell in 2025, intermittent fasting may trigger a number of side effects, including slowed hair growth, in both human and animal models. It is crucial to understand what are the side effects of intermittent fasting before beginning this popular dietary pattern to ensure it aligns with your health and lifestyle.

Quick Summary

Intermittent fasting can cause temporary side effects like headaches, fatigue, irritability, and dehydration as the body adjusts. Less common but serious risks include nutrient deficiencies, hormonal changes, and the potential for triggering disordered eating behaviors in vulnerable individuals. Some long-term effects, like impacts on heart health, are still being researched and warrant professional consultation.

Key Points

  • Initial Adjustment Period: Many side effects like headaches and fatigue are temporary and resolve within a few weeks as the body adapts to the new eating pattern.

  • Dehydration is a Key Factor: Increased water and electrolyte excretion can lead to headaches, dizziness, and fatigue if not properly managed with adequate fluid intake.

  • Potential for Nutritional Gaps: Restricting eating windows can increase the risk of micronutrient deficiencies if not careful about consuming a nutrient-dense diet.

  • Hormonal Impacts Differ by Sex: Women may experience greater hormonal disruptions, including irregular menstruation, while men might see temporary decreases in testosterone.

  • Not Suitable for Everyone: Certain individuals, such as pregnant women, children, and those with a history of eating disorders, should avoid intermittent fasting.

  • Recent Heart Health Concerns: A 2024 study raised questions about a potential link between time-restricted eating under 8 hours and increased cardiovascular mortality, highlighting the need for more long-term research.

In This Article

Intermittent fasting (IF), a dietary approach that cycles between periods of eating and fasting, has gained widespread popularity for its potential health benefits, including weight management and improved metabolic health. However, as with any major change to eating patterns, it can also lead to a range of side effects. While many of these are mild and temporary, understanding them is crucial for practicing IF safely.

Common Side Effects During the Adjustment Period

When you first begin intermittent fasting, your body needs time to adapt to the new schedule of receiving food. This transitional phase, which typically lasts for a few weeks, is when most individuals experience initial side effects.

Headaches and Dizziness

As your body transitions from using glucose as its primary fuel source to burning stored fat and producing ketones, it's common to experience headaches, lightheadedness, or dizziness. These symptoms are often linked to low blood sugar levels, caffeine withdrawal, and dehydration. Fasting can trigger a diuretic effect, causing you to flush out more water and electrolytes, which can also contribute to head pain.

Fatigue and Low Energy

Feeling tired or lethargic is another frequent complaint during the initial weeks of IF. The body's energy levels can dip as it adapts to using a new fuel source. For those accustomed to a high-carb diet, this shift can be more pronounced. However, for most, energy levels stabilize once the body becomes more efficient at using fat for fuel.

Mood Swings and Irritability

Restricting food intake can leave you feeling hungry, which in turn can lead to irritability and mood swings. The brain's response to fluctuating nutrient and hormone levels is a key factor here. As with other initial symptoms, this often subsides as your body gets used to the new routine.

Digestive Issues

Changes in meal timing can disrupt normal digestive patterns. Some people experience constipation, bloating, diarrhea, or nausea. These issues can be caused by dehydration or changes in the types of foods you consume during your eating window. For individuals with pre-existing conditions like GERD or IBS, fasting may exacerbate symptoms.

Potential Longer-Term and More Serious Risks

While most initial side effects fade, some risks are more persistent or carry more serious health implications, particularly if IF is practiced improperly or for prolonged periods.

Dehydration and Electrolyte Imbalance

As your body shifts into a fat-burning state, it can excrete more sodium and water, a process called diuresis. If not managed with proper hydration and electrolyte replacement, this can lead to persistent dehydration, which can worsen headaches, fatigue, and other symptoms.

Hormonal Disruptions

For women, intermittent fasting can pose specific hormonal challenges. Prolonged periods without food can signal to the body that there's a famine, which can disrupt reproductive hormones like estrogen and progesterone. This can lead to irregular periods or, in some cases, a complete cessation of the menstrual cycle. In contrast, some men may see a temporary reduction in testosterone, though studies suggest it does not negatively impact strength or muscle mass.

Nutrient Deficiencies

When the eating window is restricted, there is a risk of not consuming enough calories or a wide enough variety of nutrient-dense foods to meet daily nutritional needs. Over time, this can lead to deficiencies in essential vitamins and minerals, which can impact overall health and well-being.

Disordered Eating Patterns

For individuals with a history of eating disorders or those prone to restrictive behaviors, IF can be a trigger for relapse. The restrictive nature of fasting, combined with the intense focus on meal timing, can foster an unhealthy relationship with food. It can also lead to overeating or binge eating during the eating window.

Impact on Cardiovascular Health

Recent research has raised questions about the long-term safety of IF. A 2024 study presented at an American Heart Association conference suggested that people restricting their eating window to less than 8 hours daily were 91% more likely to die from cardiovascular disease than those with a more typical eating pattern. While more research is needed, this highlights the importance of professional medical advice and caution.

A Comparison of Intermittent Fasting Side Effects

Feature Common (Initial) Side Effects Serious (Potential) Side Effects
Nature Often temporary and manageable Can be persistent or pose long-term risks
Symptoms Headaches, mild fatigue, hunger, irritability Hormonal imbalances, nutrient deficiencies, disordered eating
Cause Body's adjustment to metabolic changes Prolonged practice, improper nutritional intake, pre-existing conditions
Resolution Typically resolves within a few weeks May require stopping IF or medical intervention
Associated Risks Mild dehydration, electrolyte shifts Increased risk of cardiovascular mortality (in some studies), slower hair growth

How to Mitigate Side Effects

There are several strategies to reduce the negative side effects of intermittent fasting:

  • Stay Hydrated: Drink plenty of water throughout the day, especially during fasting periods. Adding a pinch of salt or a zero-calorie electrolyte supplement can help with electrolyte balance.
  • Start Gradually: Ease into your IF schedule. Begin with shorter fasts (e.g., 12 hours) and slowly extend the fasting period as your body adjusts.
  • Eat Nutrient-Dense Foods: During your eating window, prioritize whole foods like fruits, vegetables, lean proteins, and healthy fats. This helps ensure you are meeting your nutritional needs.
  • Listen to Your Body: If you experience severe or persistent side effects, it's a sign that your body may not be responding well. Consider modifying your plan or consulting a healthcare provider.
  • Manage Caffeine Intake: If you are a heavy coffee drinker, caffeine withdrawal can cause or worsen headaches. Adjusting your timing or intake can help.

Who Should Avoid Intermittent Fasting

Intermittent fasting is not a suitable dietary pattern for everyone. Certain individuals should avoid it or proceed only under strict medical supervision:

  • Children and Teenagers: Growth and development require consistent nutritional intake.
  • Pregnant or Breastfeeding Women: Higher energy and nutrient needs are necessary for maternal and fetal health.
  • Individuals with a History of Eating Disorders: The restrictive nature can be a significant trigger.
  • People with Diabetes: Fasting can cause unsafe fluctuations in blood sugar levels, especially for those on insulin or other medication.
  • Anyone on Certain Medications: Some medications, particularly for blood pressure or heart conditions, require specific food intake timing.

Conclusion

While intermittent fasting can offer some health benefits, it is not without its potential drawbacks. Many initial side effects, such as headaches, fatigue, and irritability, are temporary and can be managed with proper hydration and a gradual approach. However, more serious risks, including hormonal disruption, nutrient deficiencies, and potential cardiovascular concerns, should not be ignored. It is essential to listen to your body and consult a healthcare professional before starting or if you experience any persistent negative symptoms. Prioritizing a nutrient-dense diet during eating periods is key to minimizing many of the adverse effects. For more information, read this guide from the Mayo Clinic.

Frequently Asked Questions

Yes, headaches and fatigue are two of the most common early side effects of intermittent fasting. They usually stem from low blood sugar, caffeine withdrawal, and dehydration as your body adjusts to the new eating schedule.

Yes, intermittent fasting can cause dehydration. During the initial phase of fasting, your body excretes more water and sodium. Staying hydrated by drinking plenty of water and replenishing electrolytes is crucial.

Intermittent fasting can cause digestive issues such as constipation, bloating, diarrhea, and nausea. These are often related to dietary changes and inadequate hydration. For individuals with conditions like GERD, fasting may worsen symptoms.

Yes, intermittent fasting can affect women's hormones. The body may interpret prolonged fasting as a period of stress or scarcity, which can disrupt reproductive hormone balance and potentially lead to irregular periods or other hormonal changes.

Feeling moody or irritable, often referred to as 'hanger,' is a common side effect, especially in the early stages of intermittent fasting. It's largely due to hunger and the metabolic shift occurring in your body.

A 2025 study suggests that intermittent fasting may slow hair growth by inhibiting the regeneration of hair follicle stem cells. Hair loss is also sometimes associated with rapid weight loss, regardless of the method.

Individuals who should avoid intermittent fasting include children, teens, pregnant or breastfeeding women, those with a history of eating disorders, people with diabetes, and anyone taking specific medications for blood pressure or other conditions.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.