The Role of Eicosapentaenoic Acid (EPA) in the Diet
Eicosapentaenoic acid (EPA) is a long-chain omega-3 fatty acid. It is known for its anti-inflammatory properties. EPA, alongside docosahexaenoic acid (DHA), is essential for cellular function in the heart, brain, and immune system. Sufficient intake of marine-based omega-3s is linked to reduced cardiovascular disease risk and improved mental health. While the body can convert alpha-linolenic acid (ALA) from plant sources into EPA, the conversion is not efficient. Direct consumption of EPA-rich foods or supplements is most effective. This guide covers the best dietary sources of EPA for various diets.
Marine-Based Foods High in EPA
Oily, cold-water fish are the primary source of eicosapentaenoic acid (EPA).
Oily Fish
- Salmon: Both wild and farmed salmon provide EPA and DHA. Wild-caught salmon generally has more omega-3s. It is versatile in preparation.
- Mackerel: Mackerel provides a high concentration of EPA. Canned mackerel is a convenient option.
- Sardines: Sardines are a small fish with a high EPA content. They are often available canned and easy to incorporate into meals.
- Herring: Herring is a good source of marine omega-3s. Pickled herring is a traditional preparation.
- Trout: Lake trout is another excellent source of EPA. It can be prepared similar to salmon.
- Anchovies: Anchovies, often cured or in oil, offer a concentrated source of EPA. They add flavor to dishes.
Shellfish
- Oysters: Oysters contain a healthy dose of EPA and other nutrients.
- Mussels: Mussels are a good source of marine omega-3s.
- Krill: Krill are a source for omega-3 supplements.
Plant-Based and Alternative EPA Sources
Individuals who do not consume fish can obtain EPA through plant-based options.
Direct EPA Sources
- Algae Oil: Algae oil is derived from microalgae, the original source of marine omega-3s. It is a vegan source of EPA and DHA.
- Seaweed and Kelp: Seaweed and kelp contain small amounts of EPA and DHA.
Indirect Sources (ALA)
Foods like flaxseeds, chia seeds, and walnuts are rich in ALA. The body converts ALA to EPA, but the conversion rate is low.
- Flaxseeds and Flaxseed Oil: Flaxseed oil is a high source of ALA.
- Chia Seeds: Chia seeds contain a significant amount of ALA.
- Walnuts: Walnuts contain ALA.
Fortified Foods and Other Sources
- Fortified Foods: Some foods are fortified with omega-3s. Check labels for EPA and DHA content.
- Grass-fed Animal Products: Meat and dairy from grass-fed animals contain slightly higher ALA levels. However, the EPA content is lower than in marine sources.
Comparison: Marine vs. Plant Sources of EPA
| Source Type | Examples | Primary Omega-3s | EPA Content | Considerations | 
|---|---|---|---|---|
| Marine | Salmon, Mackerel, Sardines | EPA & DHA | Very High | Some fish have mercury. | 
| Direct Plant-Based | Algae Oil, Seaweed | EPA & DHA | High (Algae Oil); Low (Seaweed) | Sustainable and vegan-friendly. | 
| Indirect Plant-Based | Flaxseeds, Walnuts, Chia Seeds | ALA | Low (Requires Conversion) | The body's conversion of ALA to EPA is low. | 
Conclusion
To ensure enough eicosapentaenoic acid (EPA) in the diet, oily fish are the most reliable source. Algae oil is a good alternative for vegans. Plant-based foods with ALA are not efficient for boosting EPA levels. Combining a variety of these foods with supplements is the best approach for the benefits of EPA. For more information, consult the NIH Fact Sheet on Omega-3 Fatty Acids.