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What is the 4 3 intermittent diet?

3 min read

According to research published in the Annals of Internal Medicine in April 2025, participants following a 4:3 intermittent fasting regimen experienced modestly greater weight loss over 12 months than those on a daily calorie-restricted diet. This emerging pattern of alternate-day fasting is attracting attention for its potential effectiveness and flexible structure for weight management.

Quick Summary

The 4:3 intermittent diet involves four days of regular eating and three non-consecutive days of significant calorie restriction per week. This pattern aims to create a weekly calorie deficit for weight loss and improved metabolic health.

Key Points

  • Flexible Fasting: The 4:3 diet involves fasting three non-consecutive days a week while eating normally on the other four.

  • Calorie Restriction: On fasting days, calorie intake is typically reduced significantly, often to around 500-700 calories.

  • Greater Weight Loss: A recent study showed modestly greater weight loss in the 4:3 group compared to a daily calorie restriction group over 12 months.

  • Metabolic Benefits: The diet has been linked to improvements in cardiometabolic markers such as blood pressure and cholesterol levels.

  • Consider Risks: Potential downsides include hunger, fatigue, and the risk of nutrient deficiencies if not properly managed.

  • Professional Guidance: Consulting a healthcare professional is recommended before starting, especially for individuals with pre-existing conditions or a history of eating disorders.

In This Article

What is the 4:3 Intermittent Diet?

The 4:3 intermittent diet, also known as alternate-day fasting, is an eating pattern where you consume regular meals on four days and significantly reduce calorie intake on three non-consecutive days each week. Unlike continuous daily calorie tracking, this method concentrates restriction on specific days. On fasting days, calorie intake is typically limited to about 20-25% of your usual consumption, roughly 500-700 calories. The remaining four are considered 'feeding days' where you eat normally, though a focus on healthy choices is advised.

How to Structure Your Week on the 4:3 Diet

Strategic planning of your three non-consecutive fasting days is key to following the 4:3 diet. Spreading these days out, such as fasting on Monday, Wednesday, and Friday, can make the plan more sustainable by avoiding consecutive periods of intense calorie restriction. Staying well-hydrated with water, herbal teas, or black coffee is important on fasting days to help manage hunger.

Potential Benefits of the 4:3 Diet

The 4:3 intermittent diet shows promise for weight loss and metabolic health improvements. A recent study indicated that individuals on the 4:3 plan achieved a modestly greater average weight loss (7.6%) compared to a daily calorie restriction group (5.0%) over 12 months. These benefits are thought to stem from several metabolic changes. Many find the 4:3 approach easier to stick with long-term due to the flexibility on non-fasting days. Studies suggest favorable changes in cardiometabolic factors, including lower blood pressure and improved cholesterol and fasting glucose levels. The non-consecutive fasting schedule allows for easier integration with social activities compared to more rigid diets.

Potential Downsides and Risks

Despite the benefits, the 4:3 diet is not suitable for everyone and has potential risks. Restricting calories significantly on three days weekly may increase the risk of not consuming enough essential vitamins and minerals without careful meal planning. Initial side effects like hunger, irritability, fatigue, headaches, and difficulty concentrating are common but often improve as the body adapts. The structured fasting days could be detrimental for individuals with a history of eating disorders, and medical supervision is essential in such cases. The diet is not recommended for certain groups, including pregnant or breastfeeding women, children, teenagers, individuals with type 1 diabetes, or older adults.

The 4:3 Diet vs. Other Intermittent Fasting Methods

Feature 4:3 Diet (Alternate-Day) 5:2 Diet 16:8 Diet (Time-Restricted)
Fasting Days 3 non-consecutive days 2 non-consecutive days Fasting daily (16 hours)
Eating Days 4 regular eating days 5 regular eating days Eating daily (8-hour window)
Calorie Intake on Fast Days Significantly reduced (500-700). Significantly reduced (500-600) Normal eating within window
Adherence Potentially easier than DCR due to freedom on eating days. Can be easier for some, similar to 4:3. Easier for those who prefer daily structure.
Flexibility High, as fasting days can be flexible. High, as fasting days can be chosen. Lower, as eating window is daily and fixed.
Intensity Moderate-to-high restriction on fasting days. Moderate restriction on fasting days. Low-intensity, focuses on timing.

Tips for Success on the 4:3 Diet

To optimize benefits and minimize risks on the 4:3 diet, consider these tips: focus on nutrient-rich foods on all days, drink plenty of water, plan fasting days strategically, and listen to your body. Consulting a professional is also recommended.

Conclusion

The 4:3 intermittent diet offers a structured alternate-day fasting approach that may contribute to weight loss and improved metabolic health for certain individuals. By incorporating three non-consecutive calorie-restricted days with four normal eating days, it provides a flexible alternative to daily calorie counting. While many find it easier to follow, potential risks like nutrient deficiencies and initial side effects require careful attention. Success depends on individual suitability, adherence, and a balanced, informed approach, ideally with professional guidance. For more scientific information, you can refer to the abstract of the study in the Annals of Internal Medicine.

Frequently Asked Questions

Choose three non-consecutive days for fasting to make the diet more manageable. Spreading them out (e.g., Monday, Wednesday, Friday) helps avoid consecutive days of intense restriction, which can be difficult to sustain.

On fasting days, calorie intake is typically restricted to 20-25% of your normal intake, usually around 500-700 calories, depending on your body size.

Yes, on fasting days you should stay well-hydrated. Calorie-free drinks like water, black coffee, and herbal teas are generally permitted.

A recent study found that participants on the 4:3 plan experienced greater average weight loss over a year compared to those on a daily calorie-restricted diet, possibly due to better adherence.

On your four eating days, focus on healthy, whole foods such as lean proteins, fruits, vegetables, and whole grains. While there are no calorie restrictions, it's important not to overeat to compensate for fasting days.

The diet is not recommended for children, teenagers, pregnant or breastfeeding women, individuals with a history of eating disorders, or those with certain chronic conditions like type 1 diabetes.

Common side effects include hunger, fatigue, irritability, and headaches, especially when first starting. These symptoms often decrease as your body adjusts.

The main difference is the number of fasting days; the 4:3 diet involves three fasting days per week, while the 5:2 diet has two.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.