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What is the Mayo Clinic Mediterranean diet?

4 min read

A 2024 study in Obesity Pillars showed that those following the Mayo Clinic Diet lost an average of 5.3% of their body weight in six months. This success comes from its science-backed principles, including a structured Mediterranean meal plan.

Quick Summary

The Mayo Clinic Mediterranean diet is an eating plan that focuses on plant-based foods and healthy fats to improve wellness. Its structured program promotes weight loss and improves heart health.

Key Points

  • Structured Approach: The Mayo Clinic diet provides a structured, two-phase program called "Lose It!" and "Live It!".

  • Calorie Density Focus: This principle emphasizes eating low-energy-dense foods to promote feelings of fullness on fewer calories.

  • Heart Health Priority: The diet is clinically backed to lower LDL cholesterol, reduce blood pressure, and decrease the risk of heart disease and stroke.

  • Abundance of Plants: The core of the meal plan consists of unlimited fruits and vegetables, whole grains, legumes, nuts, and healthy fats, while limiting red meat and sugar.

  • Sustainable Weight Management: Promotes long-term weight management by fostering enjoyable, balanced eating habits.

  • Reduced Inflammation: The diet's rich antioxidant and omega-3 content helps combat chronic inflammation.

In This Article

The Mayo Clinic Approach to Mediterranean Eating

The Mayo Clinic's version of the Mediterranean diet is a structured, evidence-based program designed to make this heart-healthy eating pattern sustainable for everyday life. Unlike the traditional Mediterranean diet, which is a looser eating pattern, the Mayo Clinic version provides a formal framework based on its Healthy Weight Pyramid. This framework emphasizes calorie density, helping individuals feel full on fewer calories by prioritizing whole, nutrient-dense foods. This program integrates the foundational principles of the Mediterranean lifestyle with actionable tools, guidance, and meal plans.

The Mayo Clinic Healthy Weight Pyramid and Phases

The Mayo Clinic Diet is built around its Healthy Weight Pyramid, which serves as a visual guide for making smart eating choices. This structure helps users intuitively choose low-energy-dense foods to promote satiety. The diet is divided into two phases to facilitate a gradual and lasting lifestyle change.

  • Phase 1: “Lose It!”: This is a kick-off phase lasting two weeks, focused on building five key healthy habits while breaking five unhealthy ones. It encourages adopting changes like eating more fruits, vegetables, and whole grains, and exercising more, while eliminating habits like watching TV while eating or adding sugar to foods. This phase is designed to jumpstart weight loss.
  • Phase 2: “Live It!”: In this long-term phase, the habits learned in the first phase are reinforced and maintained. Users continue to follow the Healthy Weight Pyramid, estimating servings based on calorie goals. The focus shifts to sustainable, life-long healthy living.

Key Foods: What to Eat and What to Limit

Following the Mayo Clinic's guidance means building your plate with specific food groups while minimizing others.

Foods to Emphasize (Pyramid Base to Top):

  • Vegetables and Fruits: Form the foundation of the diet and are low in calorie density, allowing for generous servings.
  • Whole Grains and Legumes: Essential sources of fiber that aid digestion and promote satiety. Examples include quinoa, farro, oats, chickpeas, and lentils.
  • Healthy Fats: Primarily extra virgin olive oil, nuts, and seeds provide beneficial fats for heart health.
  • Lean Protein and Low-Fat Dairy: Moderate portions of fish, skinless poultry, eggs, and low-fat dairy like Greek yogurt are included weekly.
  • Herbs and Spices: Used liberally to add flavor, reducing the need for excess salt.

Foods to Limit (Pyramid Top):

  • Red and Processed Meats: Intake is significantly reduced.
  • Sugary Drinks and Sweets: Highly discouraged due to high calorie density and low nutritional value.
  • Refined Grains: Replaced with whole-grain alternatives.
  • Saturated Fats: Minimizing fats like butter is recommended.

Comparing Mayo Clinic's Approach to Traditional Mediterranean Diet

While both share the same fundamental food philosophy, the Mayo Clinic version adds specific structural elements.

Feature Mayo Clinic Mediterranean Diet Traditional Mediterranean Diet
Structure A formal, two-phase program ("Lose It!" and "Live It!") guided by the Healthy Weight Pyramid. A looser eating pattern based on regional culinary habits.
Portion Control Uses calorie density principles to guide eating. Relies on mindful eating and cultural norms.
Guidance & Tools Offers meal plans, recipes, tracking tools, and online support via its program. Does not include inherent structured guidance.
Focus Explicitly designed for sustainable weight management and chronic disease risk reduction. A lifestyle pattern known for its health benefits.
Superfoods Incorporates modern research by including specific cardio-protective superfoods. Based on traditional, simple, and locally sourced ingredients.

Health Benefits of the Mayo Clinic Mediterranean Diet

The Mayo Clinic’s structured approach provides numerous scientifically validated benefits.

  • Heart Health: Reduces the risk of heart disease, stroke, and high blood pressure. Lowers LDL cholesterol and improves blood pressure.
  • Weight Management: Promotes a sense of fullness on fewer calories, leading to sustainable weight loss. Helps stabilize blood sugar and control cravings.
  • Reduced Inflammation: Fights chronic inflammation through rich antioxidant and omega-3 content.
  • Brain and Cognitive Health: Linked to better memory, focus, and reduced risk of age-related cognitive decline.
  • Long-Term Sustainability: Flexibility and balanced approach make it a realistic lifestyle.

Expert Tips for Starting the Diet

Consider these expert tips:

  • Prioritize Plants: Make vegetables, fruits, and whole grains the focus of your meals.
  • Master the Fat Swap: Replace saturated fats with heart-healthy extra virgin olive oil.
  • Rethink Your Protein: Increase fish and plant-based protein, limiting red meat.
  • Embrace Herbs: Boost flavor with herbs and spices instead of salt.
  • Plan Your Meals: Utilize meal planning tools to create structure.
  • Combine with Activity: Incorporate at least 30 minutes of daily physical activity.

Conclusion

The Mayo Clinic Mediterranean diet takes traditional principles and enhances them with a structured program. By focusing on whole, low-calorie-density foods and promoting healthy habits, it offers a sustainable path to better heart health, effective weight management, and reduced inflammation. This guided, evidence-based approach is a comprehensive strategy for long-term health. The added support from the Mayo Clinic Diet program provides tools for lasting success. For more detailed information on meal plans and dietary guidance, visit the [Mayo Clinic Diet website](https://diet.mayoclinic.org/us/blog/2025/mediterranean-meal-plan-a-step-by-step-guide-to-heart-healthy-eating/

Frequently Asked Questions

The Mayo Clinic approach adds a structured framework to the traditional Mediterranean eating pattern, using a two-phase program and the Healthy Weight Pyramid to guide portions and habits.

No, the diet does not require strict calorie counting. Instead, it focuses on foods with low calorie density, which helps you feel full on fewer calories naturally.

The diet consists of two phases: 'Lose It!,' a two-week phase to jumpstart weight loss, and 'Live It!,' a longer-term phase focused on maintaining these habits for life.

Yes, but meat intake is limited. Lean poultry and fish are consumed in moderate portions, while red and processed meats are limited.

Yes, the Mayo Clinic Diet, including its Mediterranean meal plan, is effective for sustainable weight loss by promoting low-calorie-density, high-satiety foods.

The diet encourages healthy unsaturated fats, with extra virgin olive oil as the primary added fat source. Nuts, seeds, and fatty fish also provide beneficial fats.

The diet improves heart health by lowering LDL cholesterol and blood pressure, reducing inflammation, and decreasing the risk of heart disease and stroke.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.