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Which food preservatives are carcinogenic?

4 min read

According to the World Health Organization's International Agency for Research on Cancer (IARC), processed meats are classified as a Group 1 carcinogen, largely due to the presence of preservatives like nitrites. This classification has fueled public concern over which food preservatives are carcinogenic and how they impact health. Understanding the specific risks associated with certain additives can empower consumers to make more informed dietary choices for better health.

Quick Summary

An analysis of common food additives identifies several preservatives linked to potential cancer risks, including sodium nitrite in cured meats, BHA/BHT in processed foods, and potassium bromate in baked goods. These substances are evaluated based on their mechanism and level of evidence, with some forming known carcinogens or showing carcinogenic effects in animal studies, necessitating consumer awareness.

Key Points

  • Sodium Nitrite: A preservative in cured meats that can form carcinogenic nitrosamines when cooked at high heat.

  • BHA (Butylated Hydroxyanisole): Classified as a possible human carcinogen by IARC and linked to tumors in animal studies.

  • Potassium Bromate: A flour additive banned in many countries due to its potential link to cancer in animal studies, but still used in some places.

  • Sodium Benzoate: Can react with Vitamin C to form benzene, a known carcinogen, particularly under heat and light exposure.

  • Emulsifiers (E471, E407): Some studies link high intake of certain emulsifiers to an increased risk of specific cancers, though more research is needed.

  • Processed vs. Natural Sources: The risk from nitrates and nitrites is significantly higher in processed meats compared to naturally occurring nitrates in vegetables, which come with protective antioxidants.

In This Article

Understanding the Risk of Carcinogenic Preservatives

Preservatives play a crucial role in preventing spoilage and maintaining food safety by inhibiting the growth of bacteria, yeasts, and molds. However, some have raised significant health concerns, particularly regarding their potential link to cancer. Not all preservatives pose the same level of risk, and factors such as concentration, cooking methods, and dietary intake all play a role in their potential effects on the body. Regulatory bodies like the FDA and IARC continually review the safety data for these compounds.

Sodium Nitrite and Nitrates

Sodium nitrite and sodium nitrate are curing agents used to preserve processed meats like bacon, ham, hot dogs, and sausages. They serve to prevent bacterial growth and give cured meats their characteristic color and flavor. The primary concern arises when these substances react with amino acids under high heat during cooking (e.g., frying bacon) or in the acidic environment of the stomach to form N-nitroso compounds, also known as nitrosamines.

Nitrosamines are potent carcinogens and have been linked to an increased risk of colorectal, stomach, and other digestive system cancers. Interestingly, the nitrates naturally found in vegetables like spinach and beetroot are generally not considered harmful because they are packaged with protective antioxidants, such as Vitamin C, which inhibit nitrosamine formation. In contrast, the lack of such antioxidants in cured meats, combined with high-heat cooking, creates a higher-risk environment for the formation of these harmful compounds.

Carcinogenic risk of processed meat vs. plant-based nitrates

The distinction between nitrates from processed meat and those from vegetables is crucial for understanding health risks.

Feature Nitrites/Nitrates in Processed Meats Nitrates in Vegetables
Source Added as curing and preserving agents to bacon, ham, hot dogs, and other cured meats. Naturally found in leafy greens like spinach, celery, and beets from soil absorption.
Carcinogenic Risk High. Can form carcinogenic nitrosamines when exposed to high heat or stomach acids, especially without antioxidants. Low to negligible. Are accompanied by antioxidants (like Vitamin C), which inhibit the formation of nitrosamines.
Formation of Nitrosamines Likely, particularly with high-heat cooking, due to proximity to proteins. Unlikely, due to the presence of protective compounds.
Health Benefits Often minimal, associated with processed foods high in fat and salt. Significant, including cardiovascular benefits due to conversion to nitric oxide.

Butylated Hydroxyanisole (BHA) and Butylated Hydroxytoluene (BHT)

BHA and BHT are synthetic antioxidants used to prevent fats and oils from becoming rancid in processed foods such as cereals, snacks, and chewing gum. While they have been categorized as “generally recognized as safe” (GRAS) by the FDA, concerns remain.

  • The International Agency for Research on Cancer (IARC) classifies BHA as a “possible human carcinogen” (Group 2B), based on sufficient evidence from animal studies.
  • Studies in rats and hamsters have linked high-dose dietary exposure to BHA with an increased incidence of benign and malignant tumors in the forestomach.
  • BHT has also been linked to potential cancer risks in animal studies, though it is not classified in the same category as BHA by the IARC. Concerns include its effect on hormone function and its role as a potential tumor promoter.

Potassium Bromate

Potassium bromate is a powerful oxidizing agent used as a flour additive in baked goods like breads and tortillas to strengthen dough and improve its rise. Despite being banned in numerous countries, including the European Union, Canada, and China, it remains legal in many parts of the U.S.

  • The IARC classifies potassium bromate as “possibly carcinogenic to humans” (Group 2B) based on animal studies.
  • Research has linked oral consumption of potassium bromate to renal cell tumors, mesotheliomas of the peritoneum, and thyroid tumors in experimental animals.
  • Some studies have detected residual potassium bromate in finished baked goods, indicating that it may not fully convert to a harmless form during the baking process.

Sodium Benzoate and Benzene Formation

Sodium benzoate is a common preservative in acidic foods and beverages, such as soft drinks, juices, and salad dressings. The primary health concern associated with this additive is its ability to convert into benzene, a known human carcinogen.

  • The conversion to benzene can occur when sodium benzoate is combined with ascorbic acid (Vitamin C) and exposed to light or heat.
  • While the FDA works with manufacturers to ensure benzene levels in products remain low, the long-term effects of ingesting low levels of benzene are still under scrutiny.

Conclusion: Consumer Awareness is Key

The scientific evidence points to specific food preservatives that carry carcinogenic potential, especially under certain conditions like high-heat cooking or chemical reactions. While regulatory bodies aim to set safe limits, consumer awareness is vital. Limiting intake of highly processed and cured foods is a proactive step. Prioritizing a diet rich in whole, unprocessed foods and seeking out products with clean labels can significantly reduce exposure to these potentially harmful additives and support better long-term health. It's crucial for consumers to stay informed about product ingredients and to advocate for stricter regulations on potentially dangerous food additives.

Disclaimer: The information provided is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for any health-related concerns.

Frequently Asked Questions

The main concern is that sodium nitrite can react with amino acids to form carcinogenic N-nitroso compounds (nitrosamines), particularly when cooked at high temperatures.

Yes, BHA and BHT are still used in many food products in the United States, despite being classified as potential or possible carcinogens by some health organizations.

Potassium bromate has been linked to kidney, thyroid, and other tumors in animal studies and is classified as a possible human carcinogen. It is banned in many countries but is still legally used in some places, including parts of the U.S.

Sodium benzoate can become carcinogenic when it reacts with ascorbic acid (Vitamin C) in beverages to form benzene, especially when exposed to heat and light.

No, vegetables naturally contain nitrates but also provide protective antioxidants like Vitamin C, which help inhibit the formation of harmful nitrosamines, unlike processed meats.

Emulsifiers are additives used to improve the texture and shelf life of processed foods. Recent observational studies suggest that high intake of certain emulsifiers, like carrageenans (E407) and mono- and diglycerides of fatty acids (E471), may be associated with an increased cancer risk, though more research is needed.

Minimize consumption of highly processed and cured meats, read ingredient labels carefully, opt for whole and unprocessed foods, and choose products that use natural alternatives to chemical preservatives.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.