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Are there side effects to stevia leaf extract? Exploring the safety and risks

4 min read

According to the Food and Drug Administration (FDA), highly purified stevia leaf extracts are considered "Generally Recognized as Safe" (GRAS) for use as a sweetener. Despite this designation, many people still wonder, "Are there side effects to stevia leaf extract?" and what potential health risks might be associated with this popular sugar substitute.

Quick Summary

This article explores the potential side effects associated with stevia leaf extract, including digestive issues, low blood pressure, and potential allergic reactions, and provides clarity on the distinction between purified extract and unrefined forms.

Key Points

  • High-Purity Extract is Safe: The FDA and other global authorities consider highly purified stevia leaf extract (steviol glycosides) generally safe for consumption.

  • Unrefined Forms Not Approved: Whole-leaf stevia and crude extracts are not approved for use in foods due to insufficient safety data, though some people grow their own.

  • Digestive Upset is Possible: Digestive issues like bloating and gas are often linked to sugar alcohols (e.g., erythritol) used as fillers in many commercial stevia products.

  • Caution with Medication: Stevia can lower blood pressure and blood sugar. Individuals on medications for diabetes or hypertension should consult a doctor before use.

  • Allergies are Rare: While rare, allergic reactions are possible, especially for individuals sensitive to plants in the ragweed family.

  • Potential for Gut Microbiome Impact: Some studies suggest stevia can affect gut bacteria, although research is conflicting and inconclusive on the extent of its impact on human gut health.

  • Read Ingredients Carefully: Choosing a product without added sugar alcohols or fillers can mitigate many of the common side effects.

In This Article

Understanding the Different Forms of Stevia

It is crucial to understand the distinction between the highly purified stevia leaf extract and the less refined or whole-leaf forms. While the FDA has granted GRAS status to highly purified extracts containing at least 95% steviol glycosides, the whole leaves or crude extracts are not approved for use in foods. This is because there is not enough data available on their potential health effects, particularly on the cardiovascular system and kidneys. Therefore, any discussion of side effects must differentiate between these forms.

Digestive Concerns and Sugar Alcohols

One of the most frequently reported side effects of stevia products is digestive discomfort, such as bloating, gas, cramping, and nausea. This is often not caused by the steviol glycoside compounds themselves, but by other ingredients commonly added to commercial stevia blends. Many stevia products contain sugar alcohols, such as erythritol, to add bulk and counteract the bitter aftertaste of pure stevia. For individuals sensitive to sugar alcohols, consuming these products can lead to unpleasant gastrointestinal symptoms. Recent research also indicates that non-nutritive sweeteners, including stevia, may disrupt the gut microbiome, which can lead to bloating and gas. However, studies have also produced conflicting results, with some suggesting no significant impact on gut microflora.

Impact on Blood Sugar and Blood Pressure

While stevia is a popular sugar alternative for people with diabetes due to its negligible effect on blood sugar, there are important considerations. Stevia has been shown to lower both blood sugar and blood pressure levels. For most healthy individuals, this is not a concern, but it can be an issue for certain groups.

  • For Diabetics: If you are taking medication for diabetes, combining it with stevia might cause your blood sugar to drop too low (hypoglycemia). It is essential to monitor blood sugar levels closely and consult a doctor.
  • For Individuals with Low Blood Pressure: Similarly, those with consistently low blood pressure or who are on blood pressure-lowering medications should speak with a healthcare provider before regularly using stevia. Stevia's potential to further reduce blood pressure could cause dizziness or fatigue.

Allergic Reactions

Allergies to stevia leaf extract are rare but have been reported. Since stevia is a member of the Asteraceae family of plants, people with sensitivities to related plants like ragweed, chrysanthemums, or daisies may also experience a reaction to stevia. Most documented cases of allergic reactions occurred with older, less refined stevia products, and the risk is considered very low with modern, highly purified extracts.

Potential Endocrine Disruption and Other Concerns

Some earlier studies, often involving animal subjects or lab-based experiments, raised questions about stevia’s potential to interfere with hormone production or cause reproductive issues. A 2016 study, for instance, found that human sperm cells exposed to steviol showed an increase in progesterone production. However, human research is limited and inconclusive, with no clear evidence suggesting that stevia acts as an endocrine disruptor in humans at typical consumption levels.

Common Side Effects of Stevia Leaf Extract

  • Digestive Issues: Bloating, gas, nausea, and cramping, especially when products contain sugar alcohols like erythritol.
  • Neurological Symptoms: Some individuals have reported temporary dizziness or numbness.
  • Blood Pressure Changes: A blood pressure-lowering effect that could be significant for those with already low blood pressure or on medication.
  • Allergic Reactions: Very rare, but possible for those sensitive to the Asteraceae plant family.

Stevia vs. Other Sweeteners: A Comparison

To put stevia's side effects in context, it is helpful to compare it with other common sweeteners. This comparison table highlights key differences regarding sweetness, safety, and potential health risks. | Sweetener | Sweetness (Compared to Sugar) | Calories per Serving | Potential Health Risks | |---|---|---|---| | Stevia (High-Purity Extract) | 200–400x | 0 | Mild digestive upset (often due to additives), potential interaction with medications for blood pressure/sugar. | | Aspartame (Equal) | ~200x | <1 | Phenylketonuria (PKU) risk, limited evidence of other health concerns. | | Sucralose (Splenda) | ~600x | <1 | May impact gut bacteria, associated with increased risk of heart disease in some studies. | | Saccharin (Sweet'N Low) | 200–700x | <1 | Previously linked to bladder cancer in rats, but studies showed no human risk. May harm gut bacteria. | | Erythritol (Sugar Alcohol) | ~70% | <1 | Possible digestive issues, increased risk of heart attack and stroke when combined with certain ingredients. |

Conclusion

For most people, using highly purified stevia leaf extract as a sweetener in moderation is generally safe and poses few risks. Potential side effects like digestive upset are often linked to additives such as sugar alcohols found in many commercial products. Furthermore, individuals with diabetes, low blood pressure, or allergies to certain plants should consult a doctor before making it a regular part of their diet due to potential interactions or sensitivities. The key to minimizing risks lies in choosing high-quality, pure stevia products, understanding what you are consuming, and using it in moderation.

Choosing a Stevia Product

When selecting a stevia product, take note of the following:

  • Read the Label: Check the ingredients list for added fillers or sugar alcohols that might cause digestive issues.
  • Choose High-Purity Extracts: Stick to products clearly labeled with "stevia extract" or "Stevia rebaudiana" to ensure you are consuming the FDA-approved form.
  • Consider Unflavored Options: Unflavored pure stevia extract is less likely to contain bulking agents or other additives.
  • Listen to Your Body: If you experience any adverse symptoms, consider reducing your intake or switching brands to see if the issue resolves.

Remember that while stevia is a natural, zero-calorie alternative to sugar, it is not without nuance. Responsible consumption and awareness of potential interactions can help you enjoy its sweetening properties safely.

Frequently Asked Questions

Yes, but this is often caused by sugar alcohols like erythritol that are added to many stevia products, not the stevia extract itself. Some studies also suggest a possible effect on gut bacteria.

Stevia may have a blood pressure-lowering effect. This can be a benefit for people with hypertension, but those with low blood pressure or taking related medications should monitor their intake and consult a doctor.

Allergic reactions to stevia are rare. They are most likely to occur in individuals with sensitivities to plants in the Asteraceae family, such as ragweed, but this risk is very low with highly purified extracts.

High-purity stevia extract does not raise blood sugar levels and can be a safe alternative to sugar. However, those on diabetes medication should monitor their blood glucose, as stevia can lower it further.

Early animal and lab studies raised concerns about potential endocrine disruption. However, there is insufficient evidence from human studies to suggest stevia disrupts hormones at typical consumption levels.

No, the FDA has not approved whole-leaf or crude stevia extracts for use in foods due to a lack of safety data. Only highly purified stevia extracts are deemed safe for general consumption.

Regulatory bodies have reviewed numerous long-term studies on high-purity stevia extracts and found no evidence of toxicity, cancer risk, or organ damage, suggesting no long-term side effects.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.