Does Bovine Colostrum Raise Cholesterol? Unpacking the Research

November 16, 2025 •

4 min read

In a 2009 study on patients with type 2 diabetes, a 5g dose of bovine colostrum twice daily for four weeks was shown to significantly reduce total cholesterol and triglycerides. This surprising finding contrasts with the worry that bovine colostrum might negatively impact cholesterol levels, a concern that stems from its inherent fat content.

Quick Summary

This article explores the relationship between bovine colostrum and cholesterol, analyzing clinical studies and compositional changes to determine its actual impact on blood lipid profiles. We discuss the scientific evidence suggesting a potential cholesterol-lowering effect, particularly in certain populations, and address the factors influencing colostrum's fat content.

Key Points

Not a Cholesterol Risk: Clinical studies demonstrate that bovine colostrum supplements do not raise cholesterol and may actually lower it.
Positive Lipid Effects: Research shows bovine colostrum can lead to significant reductions in total cholesterol and LDL ('bad') cholesterol, particularly in individuals with elevated levels.
Bioactive Compounds are Key: The beneficial effects are likely due to bioactive components like immunoglobulins, not the overall fat content.
Initial vs. Processed Content: While fresh colostrum has initially higher fat and cholesterol, commercially processed supplements used in studies have different lipid profiles and effects.
Inflammation Reduction: Colostrum's anti-inflammatory properties may indirectly contribute to healthier blood lipid profiles.
Consider Dosage and Processing: Excessive, non-standard consumption might pose a risk, but standard supplementation is generally considered safe for blood lipids.
Consult a Professional: Always seek advice from a healthcare provider before starting new supplements, especially if you have existing health conditions.

Understanding Bovine Colostrum's Composition

Bovine colostrum is the first milk produced by cows after calving, rich in nutrients, immune factors, and growth hormones. Its composition is distinct from mature cow's milk, offering a concentrated dose of proteins, vitamins, and minerals. Initially, colostrum has a higher concentration of fat and cholesterol compared to mature milk, but these levels decrease rapidly within the first 48 hours postpartum. While this initial fat content might fuel concerns, it's crucial to examine the overall effect of colostrum supplementation, not just its starting components.

The Role of Bioactive Compounds

Beyond simple fat content, the unique bioactive compounds in bovine colostrum are believed to influence metabolic processes. These include lactoferrin, growth factors like IGF-1, and immunoglobulins. These components have been studied for their potential to support gut health and regulate immune responses, which are increasingly linked to systemic inflammation. Chronic inflammation is a known risk factor for cardiovascular disease and can negatively impact blood lipid profiles. By potentially reducing inflammation, colostrum might indirectly support healthy cholesterol levels.

Clinical Research on Bovine Colostrum and Cholesterol

Several studies have investigated the direct effects of bovine colostrum supplementation on blood lipids, particularly total cholesterol and low-density lipoprotein (LDL) cholesterol. The results have provided evidence that, contrary to popular belief, colostrum does not raise cholesterol and may even help lower it.

Studies Supporting a Positive Effect

A 2005 randomized, placebo-controlled trial involving participants with hypercholesterolemia found that a serum bovine immunoglobulin protein fraction (a component of colostrum) significantly reduced total cholesterol and LDL cholesterol after 6 weeks. This reduction was attributed to a luminal effect within the gut, where immunoglobulins may bind endotoxins that are linked to cholesterol synthesis. Another trial in older adults (aged 50-69) consuming bovine colostrum-enriched skim milk daily for 12 weeks showed a significant reduction in total and LDL cholesterol compared to a placebo group receiving regular skim milk.

Addressing Conflicting Information

It is important to acknowledge that some sources may cite a higher fat and saturated fat content in bovine colostrum and suggest this could increase cholesterol. This interpretation can be misleading. A study from Baylor Scott & White Health mentions that if consumed in excess, the saturated fat content can possibly increase cholesterol and heart disease risk. This hypothetical risk is distinct from the results of controlled clinical trials, which use specific, non-excessive dosages and have demonstrated beneficial, rather than detrimental, effects on blood lipids. Furthermore, the initial high cholesterol content in the first hours after calving rapidly declines, meaning commercially processed supplements derived from later collections may have different lipid profiles.

Comparison Table: Colostrum's Initial Composition vs. Clinical Effects


Aspect	Initial Postpartum Colostrum	Clinically Studied Supplementation
Cholesterol Content	Relatively high in the first hours after calving; rapidly decreases.	Potentially cholesterol-lowering due to bioactive compounds.
Fat Concentration	Initially high; decreases over time.	Lower in processed supplements, especially those derived from later collections or skim milk.
Saturated Fats	Present in higher proportion initially.	Potential risk only if consumed in excessive, non-standard quantities.
Mechanism of Action	Concentrated source of initial nutrition for calf.	Luminal effects of immunoglobulins; inflammation modulation.
Effect on Blood Lipids	No direct human data for un-processed, fresh colostrum.	Studies show reduction in total and LDL cholesterol.

Considerations for Supplementation

When considering bovine colostrum supplementation, it's essential to look at the product's quality and processing. Different manufacturing methods and source timings can influence the final product's composition. For instance, colostrum-enriched skim milk will naturally have less fat and cholesterol than a full-fat version. It's also important to note that the long-term effects of bovine colostrum are still under investigation, and supplements are not regulated by the FDA. However, the existing clinical evidence, particularly from trials using standardized products, suggests that it is not likely to raise cholesterol in healthy adults when used appropriately.

Conclusion: So, does bovine colostrum raise cholesterol?

The available research strongly indicates that bovine colostrum does not raise cholesterol when taken as a supplement and may, in fact, help lower total and LDL cholesterol levels, particularly in individuals with pre-existing conditions like diabetes or hypercholesterolemia. While raw, fresh colostrum has an initially high fat and cholesterol content, commercially processed supplements used in clinical studies have demonstrated beneficial effects on blood lipid profiles. These positive outcomes are likely linked to the product's potent bioactive compounds, which influence gut health and systemic inflammation. For those concerned about their blood lipids, bovine colostrum is not a risk but a potential supportive nutrient when consumed in standard, recommended dosages. Always consult a healthcare professional before beginning any new supplement regimen.

Outbound Link: For additional reading on the potential benefits of bovine colostrum for gut and immune health, a comprehensive review article can be found at Bovine Colostrum and Its Potential for Human Health and Nutrition.

Frequently Asked Questions

No, clinical studies indicate that bovine colostrum supplements are not a cause of high cholesterol and may help lower total and LDL cholesterol levels, especially in people with existing hypercholesterolemia.

One potential mechanism involves immunoglobulins found in colostrum that can have a luminal effect within the gut, binding to inflammatory endotoxins that might otherwise promote cholesterol synthesis.

Yes, the cholesterol content is highest in the first hours after calving and decreases rapidly. Supplements are typically made from processed colostrum, which may have a different lipid profile than the initial fresh fluid.

Yes, bovine colostrum contains saturated fats, but the overall effect of standard supplementation in clinical trials has shown no negative impact on cholesterol. The risk of increasing cholesterol from saturated fat is primarily associated with excessive intake.

There is no strong evidence to suggest that individuals should avoid bovine colostrum specifically due to cholesterol concerns, based on standard dosages. However, those with a cow's milk allergy should avoid it.

LDL (low-density lipoprotein) is often called 'bad' cholesterol. Research suggests that bovine colostrum supplementation can lead to a reduction in LDL cholesterol levels.

While the effects on newborns are well-established, research on adult human supplementation is ongoing. However, several studies have investigated its impact on immune function, gut health, and cholesterol, with promising results.