How does Manuka honey affect your body? A comprehensive guide

November 28, 2025 •

5 min read

Manuka honey has been used medicinally for centuries, with its potent antibacterial properties first identified in the late 19th century. Sourced from the Manuka bush in New Zealand and Australia, this unique honey's effects on the human body are increasingly supported by scientific research, from internal wellness to external healing.

Quick Summary

Manuka honey is prized for its high methylglyoxal (MGO) content, which provides powerful antibacterial, anti-inflammatory, and antioxidant effects. This supports diverse health functions, including wound healing, digestive balance, immune system function, and skincare, distinguishing it from conventional honey.

Key Points

Antibacterial Properties: Manuka honey contains high levels of methylglyoxal (MGO), giving it potent, stable antibacterial and antimicrobial effects far stronger than regular honey.
Immune System Modulation: It acts as an immunomodulator, using its antioxidant and anti-inflammatory compounds to support the body's natural defenses and combat oxidative stress.
Digestive Wellness: This honey promotes a healthy gut environment by acting as a prebiotic and helps fight off harmful bacteria like H. pylori, which can cause ulcers.
Effective Wound Care: Approved by the FDA for topical use on wounds and burns, Manuka honey accelerates tissue regeneration and prevents infection, including against antibiotic-resistant strains.
Skincare Benefits: Its hydrating, antibacterial, and anti-inflammatory qualities make it a popular natural remedy for soothing acne, eczema, and other skin irritations.
Oral Health Support: Manuka honey can help prevent plaque buildup and reduce gingivitis by inhibiting the growth of harmful oral bacteria.

The Science Behind Manuka Honey's Unique Potency

Manuka honey's renowned health benefits stem from its unique composition, particularly the presence of methylglyoxal (MGO). This compound is found in very high concentrations in Manuka honey compared to other types, and its levels are directly correlated with the honey's antibacterial strength. A higher MGO concentration often corresponds with a higher Unique Manuka Factor (UMF) rating, an industry-standard measurement of potency and authenticity.

Unlike regular honey, whose antibacterial properties come primarily from hydrogen peroxide produced by an enzyme, Manuka honey’s non-peroxide activity is more potent and stable. This is why medical-grade Manuka honey is often used in clinical settings for its reliable antimicrobial efficacy. Other contributing factors include its naturally low pH (acidic) and high sugar content, which create an inhospitable environment for bacteria.

Impact on the Immune System

Manuka honey acts as an immunomodulatory agent, meaning it can trigger or regulate immune responses in the body.

Antioxidant and Anti-inflammatory Action

The rich content of phenolic compounds and flavonoids provides Manuka honey with powerful antioxidant and anti-inflammatory properties. Antioxidants combat oxidative stress caused by free radicals, which can weaken the immune system over time. The anti-inflammatory effects help soothe the body's inflammatory cycle, supporting balanced and efficient immune function, particularly beneficial during illness.

Supporting Against Infections

The antimicrobial properties can help the body fight off various pathogens. Studies have shown Manuka honey can inhibit the growth of bacteria and viruses, including some antibiotic-resistant strains like MRSA. When taken for a sore throat or cold, the antibacterial properties can help combat the underlying infection, while its anti-inflammatory effects reduce irritation.

Benefits for Digestive Health

Research has increasingly focused on Manuka honey's positive impact on the digestive system, where a healthy gut microbiome is crucial for overall wellness.

Balancing Gut Bacteria

Manuka honey contains oligosaccharides, a type of prebiotic, which can nourish beneficial gut bacteria. By encouraging the growth of good microbes and simultaneously inhibiting harmful ones, Manuka honey helps promote a healthier and more balanced gut environment.

Soothing Ulcers and Gastric Issues

H. pylori, a bacterium responsible for many stomach ulcers, can be inhibited by Manuka honey. The honey’s anti-inflammatory properties also help soothe the stomach lining, alleviating discomfort associated with gastritis and gastric ulcers.

External and Topical Applications

The most historically recognized use of Manuka honey is for topical wound and skin care, and modern science continues to validate this practice.

Wound and Burn Healing

The U.S. Food and Drug Administration (FDA) has approved Manuka honey for use as a wound treatment. It aids healing by:

Providing a protective barrier and maintaining a moist environment.
Attacking bacteria, including difficult-to-treat biofilm infections.
Reducing inflammation and stimulating tissue regeneration.

Skincare and Conditions

Manuka honey is a popular ingredient in skincare due to its hydrating, antibacterial, and anti-inflammatory effects. It can be beneficial for:

Acne: Fighting the bacteria that cause breakouts and reducing inflammation.
Eczema and dermatitis: Soothing irritated, sensitive skin.
Hydration: Drawing moisture to the skin's surface for a radiant complexion.

Comparison: Manuka Honey vs. Regular Honey


Feature	Manuka Honey	Regular Honey
Antibacterial Potency	Stronger, more stable due to high MGO content and non-peroxide activity.	Primarily from hydrogen peroxide; less potent and stable.
Rating System	Unique Manuka Factor (UMF) or MGO ratings to indicate potency.	No specific potency rating system exists.
Source	Nectar from the native Manuka bush (Leptospermum scoparium).	Nectar from various floral sources.
Flavor	Stronger, earthier, and slightly bitter.	Mild and varies depending on the floral source.
Cost	Significantly more expensive due to scarcity and demand.	Lower price point, widely available.
Therapeutic Use	FDA-approved medical use for wound care; extensively studied for therapeutic benefits.	Primarily for food and general use; less potent for specific therapeutic applications.

Conclusion

The effects of Manuka honey on the body are diverse and well-supported by both traditional use and modern research. Its unique chemical makeup, characterized by high levels of MGO, imparts superior antibacterial, anti-inflammatory, and antioxidant properties. This makes it a powerful natural remedy for supporting the immune system, improving digestive health, and promoting the healing of wounds and skin conditions. While not a cure-all, incorporating high-quality Manuka honey into your daily routine can provide a potent boost to your overall wellness, both internally and externally. Consistency is key to maximizing these benefits, and it is always wise to choose products with a certified UMF or MGO rating to ensure authenticity and potency. For more information, you can find a comprehensive review of Manuka honey's properties on the National Institutes of Health website at nih.gov/articles/PMC6613335/.

How does Manuka honey affect your body? A quick summary

Antimicrobial Power: Manuka honey's high MGO content makes it a potent antibacterial and antimicrobial agent, helping the body fight against various pathogens, including antibiotic-resistant strains like MRSA. Immune System Support: Rich in antioxidants and anti-inflammatory compounds, it helps protect against cellular damage and modulates immune responses for better overall health. Digestive Aid: Its prebiotic properties promote a healthy gut microbiome, while its antibacterial and anti-inflammatory actions can soothe digestive issues and help combat bacteria like H. pylori. Wound and Skin Healing: When applied topically, it creates a protective, moist healing environment, regenerates tissue, and fights infection, making it effective for wounds, burns, and skin conditions like acne. Oral Health Improvement: Studies show Manuka honey can reduce plaque formation and decrease harmful oral bacteria, potentially combating gum disease.

FAQs

question: What is the Unique Manuka Factor (UMF) rating? answer: UMF is a grading system that verifies the authenticity, purity, and potency of Manuka honey from New Zealand. A higher UMF number, which correlates with higher methylglyoxal (MGO) levels, indicates a stronger antibacterial effect.

question: Can I eat Manuka honey every day? answer: Yes, consuming small amounts daily, such as a teaspoon, is generally safe for healthy adults and can offer regular health benefits. However, those with diabetes should monitor their blood sugar levels due to the high sugar content.

question: Is Manuka honey safe for everyone? answer: Manuka honey is not safe for infants under one year old due to the risk of botulism spores. Individuals with a bee allergy should also avoid it. People with diabetes or compromised immune systems should consult a doctor before use.

question: How can I use Manuka honey for digestive issues? answer: For digestive health, you can take a teaspoon of Manuka honey directly, or mix it with warm water, herbal tea, or yogurt. It can help soothe irritation and balance gut bacteria.

question: How does Manuka honey help with skin conditions like acne? answer: Applied topically, Manuka honey fights the bacteria that cause acne, reduces inflammation and redness, and provides deep hydration to the skin. It can be used as a face mask or added to skincare products.

question: Should I use medical-grade Manuka honey for wounds? answer: Yes, for wound and burn treatment, it is best to use a certified medical-grade Manuka honey product. This ensures standardized levels of active compounds and sterility for topical application.

question: Can Manuka honey help a sore throat? answer: Yes, the antibacterial and anti-inflammatory properties can coat the throat to reduce irritation and fight bacterial infections that contribute to soreness. Mix it in warm (not hot) tea or take it directly off a spoon for relief.

Frequently Asked Questions

UMF is a grading system that verifies the authenticity, purity, and potency of Manuka honey from New Zealand. A higher UMF number, which correlates with higher methylglyoxal (MGO) levels, indicates a stronger antibacterial effect.

Yes, consuming small amounts daily, such as a teaspoon, is generally safe for healthy adults and can offer regular health benefits. However, those with diabetes should monitor their blood sugar levels due to the high sugar content.

Manuka honey is not safe for infants under one year old due to the risk of botulism spores. Individuals with a bee allergy should also avoid it. People with diabetes or compromised immune systems should consult a doctor before use.

For digestive health, you can take a teaspoon of Manuka honey directly, or mix it with warm water, herbal tea, or yogurt. It can help soothe irritation and balance gut bacteria.

Applied topically, Manuka honey fights the bacteria that cause acne, reduces inflammation and redness, and provides deep hydration to the skin. It can be used as a face mask or added to skincare products.

Yes, for wound and burn treatment, it is best to use a certified medical-grade Manuka honey product. This ensures standardized levels of active compounds and sterility for topical application.

Yes, the antibacterial and anti-inflammatory properties can coat the throat to reduce irritation and fight bacterial infections that contribute to soreness. Mix it in warm (not hot) tea or take it directly off a spoon for relief.

Manuka honey contains significantly higher levels of methylglyoxal (MGO) and possesses a more potent, stable antibacterial effect compared to regular honey. It is also sourced specifically from the Manuka bush, whereas regular honey can come from various floral sources.