How Often Should I Get a NAD+ Infusion?

January 7, 2026 •

4 min read

Studies show that natural NAD+ levels can drop by nearly half between youth and middle age, significantly impacting energy and cognitive function. Understanding how often should I get a NAD+ infusion is crucial for effectively addressing this decline and achieving specific wellness goals, such as enhanced mental clarity or improved cellular repair.

Quick Summary

The frequency of NAD+ infusions is highly individualized, depending on specific health goals like boosting energy or addressing chronic conditions. A typical treatment involves an initial loading phase to rebuild NAD+ levels, followed by a maintenance phase to sustain the benefits over time.

Key Points

Loading Phase: Initial NAD+ infusions are typically administered 1-2 times weekly for 4-6 weeks to rapidly replenish depleted levels and maximize benefits.
Maintenance Phase: Following the initial phase, a less frequent maintenance schedule of once every 1-4 weeks is common for general wellness to sustain energy and cognitive function.
Health Goals Determine Frequency: Infusion schedules vary significantly based on your goal, with anti-aging often requiring monthly maintenance and chronic conditions needing more intensive, frequent therapy.
Addiction Protocols are Intensive: For addiction recovery, an intensive loading phase of daily infusions over 4–10 days is followed by less frequent maintenance sessions.
Personalization is Key: Your age, lifestyle, existing health issues, and how you respond to treatment are critical factors in determining your optimal NAD+ infusion schedule.
Professional Guidance is a Must: Consultation with a qualified healthcare provider is essential for creating a safe and effective, personalized treatment plan.

Determining the Ideal NAD+ Infusion Frequency

Determining the right frequency for NAD+ infusions is a personalized process that depends on several factors, including your specific health goals, age, lifestyle, and how your body responds to treatment. Most protocols are structured around two distinct phases: an initial 'loading' phase and a subsequent 'maintenance' phase. During the loading phase, infusions are administered more frequently to rapidly replenish your body's NAD+ levels. The maintenance phase, which follows, requires less frequent infusions to sustain the benefits over the long term. Consulting a qualified healthcare provider is essential to create a plan that is safe and effective for your individual needs.

The Two-Phase Treatment Plan

The Loading Phase The loading phase is designed to elevate NAD+ levels quickly and efficiently. For most new patients, this involves a series of infusions over a concentrated period. A common approach is to receive infusions 1-2 times per week for 4-6 weeks. This intensive schedule helps saturate your system with the coenzyme, which is especially important for those with significant NAD+ depletion due to age, chronic stress, or underlying health conditions.

The Maintenance Phase Once your NAD+ levels are restored after the loading phase, you transition to a maintenance schedule. The goal here is to maintain optimal levels without the need for frequent, high-dose infusions. For general wellness, a maintenance infusion once every 1-4 weeks is a typical recommendation. Your provider will work with you to find the frequency that best sustains your energy, cognitive function, and other benefits. For example, some people with persistent needs might opt for bi-weekly infusions, while others find that a single monthly session is sufficient.

Tailoring Frequency to Specific Health Goals

Your reason for seeking NAD+ therapy is one of the most important factors in determining your treatment frequency. Protocols can vary significantly based on your desired outcomes.

Anti-Aging and Longevity

As a primary goal, anti-aging aims to restore youthful cellular function by addressing the age-related decline in NAD+. For this purpose, regular infusions can help support DNA repair, boost metabolism, and improve cognitive function. A recommended approach involves:

Initial: Weekly infusions for 4 weeks.
Booster: A booster infusion approximately one month later.
Maintenance: Maintenance infusions every 3-6 months or as needed.

Chronic Fatigue or Burnout

For those suffering from persistent exhaustion or burnout, an intensive initial protocol is often necessary to help rebuild cellular energy.

Loading: 5–10 sessions across 1–2 weeks.
Maintenance: Weekly, then tapering to monthly as energy stabilizes.

Addiction and Withdrawal Recovery

In addiction treatment, NAD+ therapy is often used to help with detoxification, mitigate withdrawal symptoms, and support neurological repair. This requires a highly intensive protocol under strict medical supervision.

Intensive Phase: Daily infusions for 4–10 days.
Maintenance: Weekly or bi-weekly maintenance sessions to support long-term recovery.

Athletic Performance and Recovery

Athletes use NAD+ infusions to enhance muscle repair, improve endurance, and speed up recovery. The frequency often aligns with training cycles.

Intense Training: 2–4 times per week during peak training periods.
Maintenance: Scaling back to once weekly or bi-weekly during less intensive phases.

Factors That Influence Your Personal NAD+ Schedule

Personal Health Goals: Your desired outcome, whether it's enhanced mental clarity, better energy, or cellular repair, dictates the frequency.
Current NAD+ Levels: Natural NAD+ production declines with age, meaning older individuals or those with significant stress may require more frequent doses.
Lifestyle and Activity Level: High-performance athletes or those with high-stress jobs may need more frequent infusions to sustain energy and endurance.
Underlying Medical Conditions: Chronic illnesses or neurodegenerative conditions can accelerate NAD+ depletion and may necessitate more frequent, supervised treatment.
Response to Treatment: Your body's individual response to the therapy will guide adjustments to the schedule.

Comparison Table: Frequency by Health Goal


Health Goal	Initial Frequency (Loading Phase)	Maintenance Frequency (After Loading)	Notes
General Wellness	1–2 times per week for 4–6 weeks	Every 1–4 weeks	Focuses on energy, mood, and cellular support.
Anti-Aging / Longevity	Weekly for 4 weeks	Every 3–6 months or as needed	Helps maintain cellular repair and cognitive health.
Chronic Fatigue	Daily for 5–10 sessions over 1–2 weeks	Weekly, then tapering to monthly	Protocol designed to intensely rebuild cellular energy.
Addiction Recovery	Daily for 4–10 days	Every 1–2 months	An intensive regimen supervised by a medical professional.
Athletic Performance	2–4 times per week during training	Once weekly or bi-weekly off-season	Supports endurance, muscle repair, and recovery.

The Importance of Professional Medical Guidance

While general guidelines for NAD+ infusion frequency exist, the only way to establish a truly optimal schedule is through consultation with a healthcare professional. A medical provider can assess your overall health, discuss your goals, and recommend a personalized plan that maximizes benefits while minimizing risks. They will also monitor your progress and make any necessary adjustments to your dosage and frequency based on your response. For example, in cases of complex conditions like chronic fatigue syndrome (ME/CFS), working with a knowledgeable provider is crucial, as the illness presents unique challenges.

Conclusion: Finding the Right Rhythm for Your Health

Ultimately, the question of how often should I get a NAD+ infusion has no single answer. The ideal frequency is a personalized journey, beginning with a more intensive loading phase and transitioning into a tailored maintenance schedule based on your unique health profile and objectives. For general wellness, a monthly infusion may be enough to sustain benefits, while intensive conditions like addiction recovery or chronic fatigue require more frequent sessions. By working closely with a healthcare professional, you can find the right rhythm to optimize your cellular health, boost energy, and support your long-term well-being.

Frequently Asked Questions

Some people report an immediate boost in energy and mental clarity, while others notice more gradual improvements over several sessions. The speed of results depends on individual factors and the dosage received.

Potential temporary side effects can include nausea, flushing, or headaches, especially during the infusion. These can often be managed by slowing down the drip rate.

The loading phase is an intensive initial period to quickly build up your body's NAD+ levels. This helps maximize the initial benefits and is especially useful for individuals starting with significant depletion.

Yes. Infusing too frequently can sometimes lead to uncomfortable side effects like flushing or nausea. A personalized and supervised schedule is key to finding the right balance for your body.

Intravenous NAD+ delivers the coenzyme directly into the bloodstream for immediate, high absorption. Oral precursors like Nicotinamide Riboside (NR) or Nicotinamide Mononucleotide (NMN) are taken daily to support baseline NAD+ levels, but their bioavailability is lower.

In most cases, NAD+ infusions for anti-aging or wellness purposes are not covered by insurance. However, coverage may vary for specific clinical applications, so it is important to check with your provider.

Yes. As you age, your natural NAD+ levels decline, so older individuals may benefit from a more consistent or frequent treatment plan to support cellular repair and combat age-related decline.