Is Liquorice Extract Good for You? Benefits, Risks, and Uses

October 31, 2025 •

4 min read

For centuries, liquorice extract has been a staple in traditional medicine systems across Asia and Europe, yet its modern use raises questions about safety and efficacy. This article delves into the potential health benefits of liquorice extract, exploring the evidence for its use in supporting digestive and respiratory health, as well as its topical applications for skin conditions.

Quick Summary

An examination of liquorice extract reveals its antioxidant, anti-inflammatory, and antimicrobial properties, with promising evidence for digestive and skin health benefits. The presence of glycyrrhizin, while beneficial, also poses risks like high blood pressure and low potassium in high or prolonged doses. Understanding the difference between whole extract and deglycyrrhizinated (DGL) versions is crucial for safe use.

Key Points

Glycyrrhizin is a double-edged sword: The active compound in full-strength liquorice, glycyrrhizin, provides many health benefits but can cause serious side effects like high blood pressure and low potassium if used improperly.
DGL is a safer option: Deglycyrrhizinated liquorice (DGL) removes the problematic glycyrrhizin, making it a safer choice for long-term or regular use, especially for digestive issues like ulcers and reflux.
Supports digestive health: Research confirms liquorice's traditional use for soothing and protecting the digestive tract, with evidence for its effectiveness against acid reflux and H. pylori.
Benefits skin and respiratory systems: Topically, liquorice extract can reduce hyperpigmentation and inflammation. Orally, it acts as an expectorant to soothe sore throats and coughs.
Consult a professional before use: Individuals with pre-existing conditions like hypertension or heart disease, as well as pregnant women, should avoid standard liquorice extract and seek medical advice before using any form of the herb.

The Core Components of Liquorice Extract

Liquorice extract is derived from the root of the Glycyrrhiza glabra plant and contains a complex mixture of active compounds. Its primary active constituent is glycyrrhizin, a compound that is responsible for its characteristic sweet flavor and many of its medicinal properties. However, glycyrrhizin is also the compound linked to the most serious potential side effects. This has led to the development of deglycyrrhizinated liquorice (DGL), where the glycyrrhizin is largely removed to provide the therapeutic benefits without the associated risks. Other important compounds include flavonoids like isoliquiritigenin and glabridin, which contribute to its antioxidant and anti-inflammatory effects.

Potential Health Benefits of Liquorice Extract

Digestive Health

Liquorice extract has a long history of use for soothing digestive issues, a benefit supported by modern research. The extract, particularly in its DGL form, is known for its demulcent action, which helps increase the production of protective mucus in the stomach lining.

Relieves acid reflux and heartburn: Studies suggest that daily use of liquorice extract can be more effective than some standard antacids at reducing symptoms of gastroesophageal reflux disease (GERD). It supports the repair of the stomach and esophageal lining, providing lasting relief.
Helps treat peptic ulcers: Research indicates that liquorice extract can help combat the Helicobacter pylori bacteria, a common cause of stomach ulcers, and enhance the healing process of the stomach lining.
Supports gut microbiome: Some animal studies suggest liquorice flavonoids can positively influence the gut microbiome, though more human studies are needed.

Respiratory and Immune Support

Liquorice has long been valued for its benefits to the respiratory system. The root is a well-known expectorant and demulcent, helping to soothe and clear the airways.

Soothes sore throats: Glycyrrhizin has potent anti-inflammatory properties that can help reduce throat irritation. Gargling with a liquorice solution has been found to be as effective as conventional gargles in reducing post-operative sore throat.
Eases coughs and bronchitis: The extract helps to thin and loosen mucus in the airways, providing relief for coughs and other upper respiratory conditions.

Skin Health and Appearance

Liquorice extract is a popular ingredient in dermocosmetic skincare, prized for its ability to soothe and brighten the skin.

Reduces hyperpigmentation: The compound glabridin inhibits the enzyme tyrosinase, which is crucial for melanin production. This helps to even out skin tone and fade dark spots, blemishes, and sun damage.
Calms inflammation: Its anti-inflammatory properties can help manage conditions like eczema, rosacea, and inflammatory acne, reducing redness and irritation.
Provides antioxidant protection: Rich in flavonoids, the extract protects the skin from environmental stressors and oxidative damage that can contribute to visible signs of aging.

Liver and Other Benefits

Beyond its well-known uses, liquorice also shows promise in supporting liver health and other areas.

Hepatoprotective effects: Glycyrrhizin has demonstrated protective effects against liver damage, particularly in cases of chronic alcohol-induced fatty liver disease.
Adrenal and stress support: As a natural adaptogen, liquorice may support adrenal gland function and help the body regulate cortisol, the stress hormone.

Comparison of Standard vs. Deglycyrrhizinated Liquorice (DGL)


Feature	Standard Liquorice Extract	Deglycyrrhizinated Liquorice (DGL)
Active Compound	Contains glycyrrhizin, the active compound responsible for its sweet taste and some benefits, but also side effects.	Glycyrrhizin is removed or significantly reduced, eliminating associated side effects.
Primary Use	Often used for respiratory issues, immune support, and some flavorings.	Recommended for long-term digestive health, particularly for ulcers, reflux, and gastritis.
Risks/Side Effects	High doses or prolonged use can lead to high blood pressure, low potassium, fluid retention, and other serious issues.	Generally considered safer for prolonged use as it lacks the glycyrrhizin-related side effects.
Contraindications	Avoid in individuals with heart conditions, high blood pressure, kidney disease, or who are pregnant.	Safer for wider use, but consultation with a healthcare provider is still recommended, especially if pregnant or on medication.

Important Safety Considerations and Precautions

Despite its many potential benefits, liquorice extract must be used with caution, particularly the standard variety containing glycyrrhizin. High intake or long-term use can lead to serious health problems by causing the body to retain sodium and lose potassium.

Before using liquorice extract, especially in supplement form, it is crucial to consult a healthcare professional, especially if you have:

High blood pressure or heart conditions: Liquorice can exacerbate these conditions by causing fluid retention and affecting electrolytes.
Kidney or liver disease: These conditions make individuals more sensitive to liquorice's effects.
Are pregnant or breastfeeding: High liquorice consumption during pregnancy has been linked to negative outcomes.
Are taking certain medications: Liquorice can interact with diuretics, blood thinners, and corticosteroids.

For those concerned about side effects, deglycyrrhizinated liquorice (DGL) is a much safer option for long-term or regular use, particularly for digestive support.

Conclusion

So, is liquorice extract good for you? The answer is nuanced and depends on the specific form, dosage, and duration of use. When used cautiously, liquorice extract offers several potential health benefits, particularly in its well-researched roles for soothing digestive and respiratory issues and improving skin health. Standard liquorice extract, with its glycyrrhizin content, provides potent anti-inflammatory and antiviral effects but carries significant risks if overconsumed or used for extended periods. In contrast, deglycyrrhizinated liquorice (DGL) provides a much safer alternative for consistent use, focusing on digestive health benefits while mitigating the risk of side effects like high blood pressure. Ultimately, a balanced and informed approach, with professional guidance, is key to safely leveraging the therapeutic potential of this ancient herb.

Frequently Asked Questions

The main difference lies in the glycyrrhizin content. Standard liquorice extract contains glycyrrhizin, the compound responsible for its potential side effects. DGL, or deglycyrrhizinated liquorice, has had this compound removed, making it safer for long-term or regular consumption.

Yes, it can. Particularly, DGL is often recommended for soothing acid reflux and heartburn. It works by stimulating the production of protective mucus that coats and protects the lining of the stomach and esophagus.

Yes, it is beneficial for skin health. When applied topically, liquorice extract's anti-inflammatory and antioxidant properties help calm irritation, reduce redness, and fade dark spots and hyperpigmentation.

Excessive or prolonged consumption of standard liquorice extract can lead to serious side effects, including high blood pressure, fluid retention (edema), and low potassium levels (hypokalemia), which can lead to heart problems.

Individuals with pre-existing conditions like high blood pressure, heart disease, or kidney problems should avoid standard liquorice extract. Pregnant and breastfeeding women are also advised to avoid it. Always consult a doctor before use.

Liquorice has traditionally been used to soothe sore throats due to its demulcent and anti-inflammatory properties. Gargling with a liquorice solution has been shown to be effective, but use should be short-term to avoid the side effects of glycyrrhizin.

Because the glycyrrhizin has been removed, DGL is considered much safer for long-term use than regular liquorice extract. However, even with DGL, it is wise to consult with a healthcare provider, especially if you have other health conditions or are on medication.