What is Sodium Sulphite?
Sodium sulphite ($Na_2SO_3$) is an inorganic salt widely used as a preservative and antioxidant in the food industry. As a food additive, its primary function is to prevent spoilage, inhibit microbial growth, and stop foods from browning due to oxidation. It is commonly found in dried fruits, baked goods, processed meats, and, perhaps most famously, in wines and beers. Sulfites can also occur naturally during fermentation.
Sulphite Sensitivity vs. True Allergy
For the vast majority of people, consuming sodium sulphite in regulated amounts poses no health risk. The potential problems are almost exclusively confined to a small subset of the population with a sulfite sensitivity or intolerance. It is important to distinguish this from a true IgE-mediated allergy, which is extremely rare for sulfites. Sensitivity reactions, though not a true allergy, can still cause significant and sometimes severe symptoms in susceptible individuals. Some of the proposed mechanisms for sulfite sensitivity include the inhalation of sulfur dioxide gas released from the sulphite in the stomach, or a deficiency in the enzyme sulfite oxidase, which is needed to break down sulphites.
Symptoms of Sulphite Sensitivity
Reactions to sulphites can vary widely in severity and type, though they often affect multiple body systems. The symptoms can appear quickly, within 15 to 30 minutes of ingestion, and range from mild to life-threatening.
Commonly reported symptoms include:
- Respiratory: Wheezing, coughing, chest tightness, shortness of breath, and nasal congestion. This is the most common form of reaction, particularly in asthmatics.
- Dermatological: Hives (urticaria), skin rashes, redness, itching, and swelling of the face, lips, or tongue.
- Gastrointestinal: Nausea, vomiting, diarrhea, and abdominal pain.
- Cardiovascular: Flushing, dizziness, and low blood pressure.
- Severe reactions: In rare cases, sulphite sensitivity can lead to anaphylaxis, a severe, full-body reaction that can cause collapse and circulatory issues.
Who is at Risk?
While anyone can develop a sensitivity at any time, certain groups are at a higher risk of adverse reactions.
- Asthmatics: This group is disproportionately affected by sulfite sensitivity, with an estimated 5–13% experiencing symptoms after ingesting sulfites. Asthmatics who are steroid-dependent or have marked airway hyperresponsiveness are at greater risk.
- General Population: The FDA estimates that less than 1% of the general population has a sulfite sensitivity. Adverse reactions in non-asthmatics are considered extremely rare.
Sodium Sulphite in Foods and Medications
Sodium sulphite and its related compounds (like potassium metabisulphite) are widespread, serving as indispensable preservatives for food manufacturers. However, regulatory bodies like the FDA have placed restrictions on their use in certain foods due to safety concerns for sensitive individuals.
Foods that often contain added sulphites:
- Dried fruits (especially apricots and raisins)
- Wines and beers (both natural and added)
- Pickled foods and condiments
- Fruit juices
- Processed potatoes (pre-cut or dehydrated)
- Certain baked goods and dough products
Sulphites are also present in some medications, cosmetics, and topical treatments as a stabilizer.
Managing Sulphite Sensitivity
For those who are sensitive, the primary management strategy is to avoid sulphite-containing products. Reading food labels is critical for this purpose. Ingredients to watch for include:
- Sodium sulfite
- Sulfur dioxide
- Potassium bisulfite
- Potassium metabisulfite
- Sodium metabisulfite
Sulfite Sensitivity vs. Sulfa Allergy
It is important not to confuse sulfite sensitivity with a sulfa allergy. A sulfa allergy is a reaction to sulfonamide-containing antibiotics, which are chemically unrelated to sulfites.
| Feature | Sulphite Sensitivity | Sulfa Allergy | 
|---|---|---|
| Trigger | Sulphite additives ($SO_3^{2-}$) and naturally occurring sulphites | Sulfonamide-containing drugs like some antibiotics | 
| Mechanism | Non-immune sensitivity reaction, possibly enzyme deficiency or chemical irritation | True IgE-mediated immune system response to the sulfa drug | 
| Symptoms | Respiratory, skin, and gastrointestinal reactions. Can trigger asthma. | Skin rashes, fever, and in severe cases, anaphylaxis. | 
| Cross-Reactivity | No cross-reactivity with sulfa drugs or sulfates. | No cross-reactivity with sulfites. | 
Conclusion
For the majority of the public, sodium sulphite is a safe and effective preservative regulated by food safety authorities like the FDA. The real health concerns are concentrated among a small percentage of the population with sulphite sensitivity, particularly asthmatics, who can experience a range of mild to severe allergy-like symptoms. For these individuals, careful label reading and avoidance are key to managing symptoms and preventing adverse reactions. Individuals with severe sensitivities should carry an emergency epinephrine auto-injector.
For more detailed information on regulations and safety, consult the FDA's guidance on food additives.