What Exactly are Sweeteners 951 and 950?
Sweeteners 951 and 950 are the European E-number identifiers for aspartame and acesulfame potassium, respectively. These are high-intensity, non-nutritive sweeteners, meaning they are significantly sweeter than table sugar (sucrose) but provide little to no calories. They are widely used as sugar replacements in products like diet sodas, sugar-free gum, and various baked goods.
Aspartame (Sweetener 951): A Closer Look
Aspartame is an artificial sweetener composed of two amino acids: aspartic acid and phenylalanine. It is approximately 200 times sweeter than regular sugar and is known by brand names like Equal®, NutraSweet®, and Sugar Twin®.
Key characteristics of aspartame include:
- Composition: A dipeptide made of aspartic acid and phenylalanine.
 - Caloric Value: Contains 4 calories per gram, but is used in such small amounts that its caloric contribution is negligible.
 - Heat Stability: It is not heat-stable and loses its sweetness when exposed to high temperatures, making it unsuitable for baking.
 - Important Precaution: Because it contains phenylalanine, products with aspartame must carry a warning for individuals with the rare genetic disorder phenylketonuria (PKU), who cannot metabolize this amino acid.
 - Applications: Commonly found in tabletop sweeteners, diet sodas, sugar-free gum, cereals, and powdered beverages.
 
Acesulfame Potassium (Sweetener 950): Key Characteristics
Acesulfame potassium, also known as acesulfame K or Ace-K, is a potassium salt derived from an organic acid. It is also about 200 times sweeter than sugar and is often used in combination with other sweeteners to mask its slightly bitter aftertaste.
Key characteristics of acesulfame potassium include:
- Composition: A synthetic chemical salt.
 - Caloric Value: Provides zero calories.
 - Heat Stability: Unlike aspartame, Ace-K is heat-stable, allowing it to be used in baking and cooked foods.
 - Synergistic Effect: When blended with other sweeteners like sucralose or aspartame, it can create a more balanced, sugar-like taste profile.
 - Applications: Found in baked goods, frozen desserts, candy, beverages, and chewing gum, as well as some pharmaceuticals.
 
The Science of Safety and Health Effects
The safety of artificial sweeteners like sweeteners 951 and 950 has been a topic of debate for decades, leading to extensive research and re-evaluations by global health authorities. Regulatory bodies like the U.S. Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA) have consistently concluded that these sweeteners are safe for consumption within established Acceptable Daily Intake (ADI) levels.
However, emerging research and ongoing studies present a more nuanced picture, often leading to public confusion. A key distinction must be made between regulatory assessments based on safety and newer studies exploring potential long-term metabolic or gut microbiome effects.
Recent Research and Controversies
- Gut Microbiome: Some studies suggest artificial sweeteners can alter the composition of the gut microbiota in animal and human trials, which may affect metabolic health, though results are inconsistent.
 - Glucose Regulation: Some research, including a 2022 study in Cell, suggested certain sweeteners could impair glucose tolerance in healthy individuals by affecting gut bacteria, though this effect was not observed in all participants.
 - Disease Associations: A 2022 French cohort study found an association between high consumption of Ace-K and aspartame and increased overall cancer risk. However, the researchers noted more large-scale studies are needed to confirm this association.
 - Cardiovascular Health: Some observational studies have linked artificial sweetener consumption to a higher risk of cardiovascular events, including stroke (linked with aspartame) and coronary heart disease (linked with Ace-K), but these associations do not prove causation.
 
The Official Stance
Despite these emerging studies, major regulatory bodies maintain their safety assessments, largely because the ADI levels are set with a high margin of safety. For instance, the FDA states that scientific evidence continues to support the safety of aspartame for the general population when consumed within approved conditions. The World Health Organization (WHO), while acknowledging some limited studies, has concluded that the evidence for an association between aspartame and cancer in humans is not convincing based on current usage. They recommend further investigation but have not deemed it unsafe at typical doses.
How to Read Food Labels and Manage Intake
To make informed decisions, it's crucial to know what to look for on product labels. Ingredient lists will specify acesulfame potassium or aspartame by name, in addition to their E-numbers (950 and 951). You can find this information by checking the ingredient list, especially for products advertised as “diet,” “sugar-free,” or “zero-sugar.”
A Comparison of Sweeteners 951 and 950
| Feature | Sweetener 951 (Aspartame) | Sweetener 950 (Acesulfame K) | 
|---|---|---|
| Sweetness | ~200x sweeter than sugar | ~200x sweeter than sugar | 
| Caloric Value | Negligible calories | Zero calories | 
| Heat Stability | Not heat-stable; loses sweetness when heated | Heat-stable; suitable for baking | 
| Aftertaste | Generally no bitter aftertaste | Can have a slightly bitter aftertaste, especially at high concentrations | 
| Usage | Diet sodas, sugar-free gum, tabletop sweeteners | Baked goods, beverages, tabletop sweeteners (often blended) | 
| PKU Warning | Contains phenylalanine; must be avoided by those with PKU | No specific warning for PKU | 
Conclusion: Making Informed Nutritional Choices
Sweeteners 951 and 950, or aspartame and acesulfame potassium, are functional food additives that allow for the reduction of added sugars and calories. They are considered safe by major global health authorities within their Acceptable Daily Intake levels, but ongoing research highlights potential associations with metabolic changes and gut health alterations, especially with high consumption. For most people, moderate consumption as part of a balanced diet is considered low-risk. Individuals with specific conditions like PKU must strictly avoid aspartame. When making choices for a nutritional diet, it is always best to read labels carefully and consider the totality of your food and drink intake. While diet drinks and sugar-free products can help curb calorie intake from sugar, maintaining a diverse, nutrient-rich diet with a focus on whole foods remains the gold standard for long-term health. For the latest safety evaluations, consulting resources from organizations like the FDA and WHO can provide valuable information.