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Understanding the Side Effects of Indian Borage (Plectranthus amboinicus)

5 min read

While widely used in traditional medicine for its respiratory and digestive benefits, excessive consumption of Indian borage (Plectranthus amboinicus) is known to cause mild gastrointestinal discomfort. It is crucial to understand the distinct side effects of this herb compared to common borage (Borago officinalis) to ensure safe usage.

Quick Summary

Indian borage, or Plectranthus amboinicus, may cause mild stomach upset when consumed in large amounts. This article clarifies the significant difference in safety profiles between Indian borage and common borage, which is associated with more severe risks, and details important precautions for users.

Key Points

  • Misidentification is Key: The most severe side effect warnings are associated with common borage (Borago officinalis), not the safer Indian borage (Plectranthus amboinicus), highlighting the need for correct identification.

  • Mild GI Discomfort: For genuine Indian borage, side effects are mild and include stomach upset, bloating, and nausea, primarily due to excessive intake.

  • Liver Damage Risk: Common borage contains hepatotoxic pyrrolizidine alkaloids (PAs) that can cause severe liver damage, especially with chronic use.

  • Increased Bleeding: The GLA in common borage oil can increase bleeding time, a risk for those with bleeding disorders or on blood-thinning medication.

  • Pregnancy Warning: Common borage should be strictly avoided during pregnancy and breastfeeding due to the dangers posed by PAs to the mother and infant.

  • Drug Interaction Alerts: Both types of borage have potential drug interactions, particularly with blood thinners and certain liver-metabolized medications.

In This Article

Distinguishing Indian Borage from Common Borage

Many people confuse Indian borage (Plectranthus amboinicus, also known as Cuban oregano or ajwain plant) with common borage (Borago officinalis, or starflower), but they are two completely different plants from different families. The vast majority of severe side effect warnings in herbal literature pertain to Borago officinalis, not the Indian variety. The risks associated with common borage are largely due to its content of pyrrolizidine alkaloids (PAs), which are toxic to the liver, and gamma-linolenic acid (GLA), which can affect blood clotting. The confusion between these two herbs is a significant source of misinformation regarding the safety of Indian borage.

Side Effects of True Indian Borage (Plectranthus amboinicus)

For the herb correctly identified as Indian borage, side effects are generally mild and linked to excessive intake. The plant is widely considered safe for consumption in moderate culinary and traditional medicinal quantities. Potential side effects can include:

  • Gastrointestinal Upset: The most commonly reported issues are stomach upset, bloating, excessive gas, and nausea. These effects usually subside when the intake is reduced or discontinued.
  • Heartburn: Some individuals may experience heartburn, especially when consuming larger quantities or when their body is not accustomed to the herb.
  • Heating Effect: In some traditional medicinal systems, Indian borage is considered to be 'heating', and excessive use is warned against to prevent imbalance.
  • Allergic Reactions: As with any plant, an allergic reaction is possible, though rare. Symptoms may include a skin rash or irritation.

Serious Risks Associated with Common Borage (Borago officinalis)

It is critical to be aware of the more serious risks of common borage (Borago officinalis) to avoid misattribution. This plant is a known source of compounds that can cause significant harm, particularly when consumed in large doses or over long periods.

Liver Toxicity

Common borage contains pyrrolizidine alkaloids (PAs), which are hepatotoxic and can cause severe liver damage, especially when used chronically. For this reason, it is strongly advised to only use common borage oil that is certified PA-free. The leaves, flowers, and microgreens contain the highest levels of PAs and pose a substantial risk.

Increased Bleeding Risk

The seeds of common borage are a rich source of gamma-linolenic acid (GLA). While GLA has some beneficial properties, it can also act as a blood thinner, increasing the risk of bruising and bleeding. Individuals with bleeding disorders or those taking anticoagulant medications should use extreme caution.

Seizure Risk

Rare case reports have linked the ingestion of very high doses of common borage oil to seizures. Individuals with a history of epilepsy or those on medications that lower the seizure threshold should avoid it.

Pregnancy and Breastfeeding Warnings

Due to the presence of PAs and other potentially harmful compounds, common borage is considered unsafe for pregnant or breastfeeding women. The alkaloids can pass to the fetus or infant through breast milk and cause serious harm.

Blue Baby Syndrome

Consumption of pureed common borage, which can contain high nitrate levels, has been linked to a rare blood disorder called blue baby syndrome (methemoglobinemia) in infants. This is another reason to avoid this herb during early childhood.

Drug Interactions and Contraindications

When considering Indian borage, it's wise to consider general interactions applicable to the Coleus genus, which includes some forms of Indian borage, and specific interactions for common borage.

Coleus Species (including Plectranthus amboinicus):

  • Blood Thinners: Some compounds, particularly forskolin from certain Coleus varieties, may increase the risk of bleeding.
  • Blood Pressure Medications: Forskolin can lower blood pressure, which could cause it to drop too low in conjunction with antihypertensive drugs.

Common Borage (Borago officinalis):

  • Blood Thinners & NSAIDs: Increases bleeding risk with anticoagulants (warfarin, clopidogrel) and NSAIDs (aspirin, ibuprofen).
  • Liver-Toxic Medications: Using it with drugs that affect the liver (ketoconazole, anabolic steroids) can increase the risk of liver damage due to PAs.
  • Phenothiazines: May increase the risk of seizures when taken with phenothiazine medications.

Comparison Table: Indian Borage vs. Common Borage

Feature Indian Borage (Plectranthus amboinicus) Common Borage (Borago officinalis)
Hepatotoxic PAs No significant risk reported in human studies Significant risk, especially from leaves and flowers
GLA Content Not a significant source High, especially in seed oil, increasing bleeding risk
Common Side Effects Mild gastrointestinal upset from high intake Nausea, cramps, diarrhea, and headache
Severe Risks No serious risks with moderate use Liver toxicity, seizures (high doses), bleeding issues
Contraindications Caution with blood thinners, blood pressure meds Pregnancy, breastfeeding, liver disease, epilepsy, surgery

Safe Use and Recommended Dosages

For Indian borage (Plectranthus amboinicus), safety depends largely on dosage and form. Moderate use in cooking is generally safe for healthy individuals. For medicinal purposes like soothing a cough, a single crushed leaf with honey is a common remedy. It is not recommended to use the same leaf more than twice in a steamer for respiratory relief. The key is moderation and listening to your body's response, as excessive intake can cause discomfort. It is crucial to avoid long-term use and high dosages of common borage (Borago officinalis), and pregnant or breastfeeding women must avoid it entirely. For common borage oil, always ensure it is certified PA-free. As with any herbal supplement, consulting a healthcare professional before use is recommended, especially for those with pre-existing conditions or on other medications. A comprehensive overview of borage oil, its uses, and precautions can be found on Healthline.

Conclusion

While Indian borage (Plectranthus amboinicus) and common borage (Borago officinalis) share a name, their safety profiles are dramatically different. Indian borage, when used in moderation, poses minimal risk and its side effects are typically limited to mild gastrointestinal discomfort from overconsumption. In contrast, common borage contains toxic pyrrolizidine alkaloids and high levels of GLA, which present a serious risk of liver damage, increased bleeding, and other severe health issues. The critical takeaway is to correctly identify the plant and follow appropriate usage guidelines. Never use common borage medicinally without proper certification (PA-free) and professional guidance, and avoid it entirely if pregnant or breastfeeding. By understanding these key distinctions, consumers can use Indian borage safely and avoid the hazards associated with its unrelated namesake.

Key Takeaways

  • Misidentification Risk: Indian Borage (Plectranthus amboinicus) is a different plant than common borage (Borago officinalis), and misidentification can lead to severe health risks.
  • Indian Borage Safety: In moderate culinary and traditional doses, Indian borage is generally considered safe, with side effects limited to mild digestive upset from overconsumption.
  • Common Borage Dangers: Common borage contains hepatotoxic pyrrolizidine alkaloids (PAs) and high levels of GLA, posing risks of liver damage, bleeding, and seizures.
  • Pregnancy and Breastfeeding: All products derived from common borage (Borago officinalis) are contraindicated for pregnant and breastfeeding women due to the risk posed by PAs.
  • Drug Interactions: Exercise caution with Indian borage if on blood thinners or blood pressure medication, and avoid common borage if taking blood thinners, liver-toxic drugs, or phenothiazines.
  • Certified Products: Always opt for certified PA-free products when purchasing supplements derived from common borage to mitigate liver toxicity risks.

Frequently Asked Questions

No, Indian borage (Plectranthus amboinicus) is not considered toxic when consumed in moderate culinary or traditional medicinal amounts. Side effects are typically mild gastrointestinal upset resulting from excessive intake.

Indian borage has very mild side effects, mainly digestive issues. In contrast, common borage (Borago officinalis) contains toxic compounds (PAs) that can cause severe liver damage, increased bleeding risk, and neurological issues.

Indian borage is not known to cause liver damage. The risk of liver toxicity is specifically associated with common borage (Borago officinalis), which contains hepatotoxic pyrrolizidine alkaloids (PAs).

The safety of using Indian borage supplements during pregnancy or breastfeeding is not well-established due to insufficient research. It is best to avoid it during these periods and consult a healthcare provider.

Some compounds in the Coleus family, including certain varieties of Indian borage, can have effects on blood pressure. It is advisable to consult a doctor if you are on blood pressure medication before using Indian borage.

Allergic reactions to borage, though rare, can include a skin rash, hives, itching, dizziness, sudden tiredness, or trouble breathing. If you experience any of these symptoms, discontinue use immediately and seek medical attention.

No, Indian borage poisoning in dogs can lead to intense irritation of mucous membranes, vomiting, weakness, and muscle tremors. Do not give Indian borage to pets.

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.