Skip to content

What are the side effects of ammonium sulfate in food?

3 min read

The U.S. Food and Drug Administration considers food-grade ammonium sulfate a Generally Recognized as Safe (GRAS) additive. While typically benign in small, regulated amounts, the side effects of ammonium sulfate in food when consumed in large, unregulated quantities can include gastrointestinal discomfort.

Quick Summary

Ingesting large, non-food-grade amounts of ammonium sulfate can cause gastrointestinal side effects such as nausea and diarrhea. However, as a regulated food additive (E517) used in small quantities, it is widely considered safe for consumption.

Key Points

  • Generally Recognized as Safe (GRAS): The U.S. FDA classifies food-grade ammonium sulfate as GRAS when used as specified.

  • High-Dose Side Effects: Consuming very large, unregulated amounts can cause gastrointestinal irritation, including nausea, vomiting, and diarrhea.

  • Minimal Risk from Food: The small, regulated quantities used in food processing pose no significant risk to the average consumer.

  • Food-Grade vs. Industrial-Grade: Food-grade ammonium sulfate is a highly purified version, distinct from the industrial-grade chemical used for fertilizers and other non-food applications.

  • Primarily a Chemical Risk: The more serious health effects, such as respiratory irritation and systemic issues, are linked to occupational or accidental exposure to industrial forms, not normal food intake.

  • Usage as Acidity Regulator: In food, its main function is as an acidity regulator and yeast nutrient in breads and doughs.

In This Article

What is Ammonium Sulfate in Food?

Ammonium sulfate ($ (NH_4)_2SO_4 $) is an inorganic salt that serves several functions in the food industry. It is designated by the E number E517 in the European Union. Primarily, it acts as an acidity regulator and dough conditioner in baked goods, particularly breads and flours, by providing a source of nitrogen for yeast during fermentation. It is also used as a firming agent and texturizer in certain foods and as a nutrient supplement in processes like brewing. The key distinction lies between industrial-grade ammonium sulfate, used for fertilizers and other chemical applications, and the highly purified, food-grade version used in consumer products.

Safety and Regulation of Food-Grade Ammonium Sulfate

Regulatory bodies worldwide, including the U.S. FDA, have evaluated food-grade ammonium sulfate and deemed it safe for its intended use. Its status as "Generally Recognized as Safe" (GRAS) is contingent on its use in specific, limited applications and at low concentrations. A 2006 study on chronic toxicity and carcinogenicity in rats, for example, found no evidence of cancer, confirming the compound's safety at regulated dietary levels. It's crucial to understand that these safety assessments apply only to the food-grade substance used within legal limits and not to the much more concentrated industrial-grade compound.

Understanding the Side Effects of Ammonium Sulfate

While industrial or occupational exposure to ammonium sulfate can cause significant health issues, the side effects from consuming regulated food-grade amounts are minimal or non-existent for most people. The health concerns arise from large, accidental ingestions of non-food-grade material.

Potential Side Effects from High-Dose Ingestion

In cases of substantial overconsumption of ammonium sulfate, potential side effects are primarily gastrointestinal. These symptoms are caused by the irritation of the digestive tract and can include:

  • Nausea and vomiting
  • Diarrhea
  • Abdominal pain or cramping
  • Sore throat

More severe but rarer effects have been noted in cases of large, acute ingestion of high concentrations, including systemic ammonia poisoning and potential kidney damage. This is not a risk associated with the trace amounts found in processed foods.

Industrial vs. Food-Grade Ammonium Sulfate

It is vital to distinguish between the grades of ammonium sulfate, as their purity and intended uses are drastically different.

Feature Food-Grade Ammonium Sulfate Industrial-Grade Ammonium Sulfate
Purity High purity, meets strict food safety standards Lower purity, contains contaminants not safe for consumption
Regulatory Status FDA GRAS, EU E517 Regulated for industrial use only, not for food
Typical Use Acidity regulator, yeast nutrient in foods Fertilizer, flame retardant, laboratory reagent
Side Effects (Normal Use) None expected at regulated levels Potential for irritation (skin, eyes, respiratory) from dust
Side Effects (Overdose) Gastrointestinal upset from massive, accidental intake Potential for serious systemic toxicity

Who Should Be Cautious?

While food-grade ammonium sulfate is safe for the general population, individuals with specific conditions or sensitivities might be more prone to adverse effects.

  • Individuals with Asthma: Those with asthma may be at an increased risk of respiratory irritation if exposed to airborne dust particles of ammonium sulfate, though this is primarily an occupational hazard.
  • Existing Gastrointestinal Sensitivities: People with pre-existing digestive conditions may experience more pronounced symptoms from even moderate doses if accidentally ingested, though this is rare with food-grade applications.

Authoritative Sources on Safety

For more in-depth information, the U.S. Food and Drug Administration (FDA) provides resources on substances affirmed as Generally Recognized as Safe (GRAS). For instance, their online database can be consulted for more details on E517 (Ammonium sulfate) regulatory status and usage conditions.

Conclusion

For the average consumer, the side effects of ammonium sulfate in food are not a concern. The food-grade version is rigorously tested and used in quantities considered safe by regulatory bodies like the FDA. Adverse effects such as gastrointestinal distress (nausea, diarrhea) are almost exclusively associated with accidental ingestion of large, concentrated amounts of industrial-grade ammonium sulfate, not with normal dietary intake. As with any food additive, those with specific health concerns should consult a medical professional, but for the vast majority, E517 presents no significant health risk when consumed as part of a balanced diet within regulated food products.

Frequently Asked Questions

Yes, food-grade ammonium sulfate (E517) is considered safe for consumption by the FDA and other regulatory bodies when used in the small, regulated quantities found in food products like baked goods.

Accidental ingestion of large amounts of industrial-grade ammonium sulfate can cause severe gastrointestinal irritation, leading to nausea, vomiting, and diarrhea. If this occurs, immediate medical attention is required.

The main difference is purity and regulation. Food-grade ammonium sulfate is a highly purified form that meets strict safety standards for consumption, while industrial-grade versions contain impurities and are not safe for food.

Ammonium sulfate is most commonly found in commercial breads, flours, and other baked goods, where it is used as a dough conditioner and yeast food.

No, ammonium sulfate is not considered carcinogenic. Studies, including a 2006 carcinogenicity study, have found no link between dietary administered ammonium sulfate and cancer.

In normal dietary intake, consuming food with E517 (ammonium sulfate) is not expected to cause these effects. Gastrointestinal upset is a side effect of ingesting large, unregulated doses, not the trace amounts in processed foods.

There are no known long-term health risks from consuming regulated, food-grade ammonium sulfate. Chronic toxicity and carcinogenicity studies have found no adverse effects at typical dietary levels.

References

  1. 1
  2. 2
  3. 3
  4. 4

Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.