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What Are the Side Effects of Flavour Enhancer 627?

4 min read

According to food safety authorities like the FDA, Flavour enhancer 627 (Disodium Guanylate) is generally considered safe for consumption. However, a small minority of sensitive individuals may experience adverse reactions, including headaches, nausea, and allergic-type symptoms, after consuming this additive.

Quick Summary

Flavour enhancer 627, also known as Disodium Guanylate, is generally safe but can cause reactions in sensitive people, triggering symptoms like headaches, dizziness, nausea, and skin rashes. Individuals with gout or MSG sensitivity should be particularly cautious.

Key Points

  • Identity: Flavour enhancer 627 is Disodium Guanylate, a food additive that boosts the savory umami taste in processed foods.

  • Sensitivity Concerns: While generally safe for most, some individuals report adverse reactions including headaches, nausea, dizziness, and skin rashes.

  • Gout Risk: Those with gout or a history of uric acid kidney stones should avoid E627 because it can increase uric acid levels.

  • Allergy-Like Symptoms: For sensitive individuals, E627 can cause skin rashes (known as Ribo Rash), swelling, and breathing difficulties.

  • Check Labels Carefully: E627 may be listed under various names like Disodium Guanylate, or potentially hidden within "natural flavors" on product labels.

  • Not an Allergy: Reactions to E627 are typically categorized as sensitivities or intolerances rather than true allergies, though they can present similar symptoms.

  • Associated with MSG: E627 is often paired with MSG, and individuals sensitive to one may also react to the other or their combination, known as I+G.

In This Article

What is Flavour Enhancer 627?

Flavour enhancer 627, formally known as Disodium 5′-Guanylate, is a food additive used to enhance the savory, or 'umami,' taste in various processed foods. It is often used in conjunction with other enhancers, most notably monosodium glutamate (MSG or E621) and disodium inosinate (E631), to create a powerful flavor synergy. Because of its ability to boost flavor, it is a common ingredient in many convenience items, seasonings, and packaged snacks.

Common Sources of Flavour Enhancer 627

Flavour enhancer 627 can be found in a wide variety of commercially produced products, including:

  • Instant noodles
  • Chips and other savory snacks
  • Canned and processed soups
  • Seasoning blends and bouillon cubes
  • Sauces and gravies
  • Processed meats and fish products
  • Certain dairy items, such as flavored cheeses

How is E627 Made?

E627 is a chemically produced additive, typically made through the fermentation of sugar or tapioca starch to obtain guanosine, which is then processed into disodium guanylate. While it is often considered vegan, its manufacturing process and source material should be verified by those with strict dietary restrictions, as it could potentially be derived from animal sources.

Potential Adverse Reactions to Flavour Enhancer 627

While the majority of the population can consume E627 without issue, a subgroup of sensitive individuals may experience adverse reactions. These reactions are often described as sensitivities rather than true allergies, though they can manifest with allergy-like symptoms.

Allergic and Sensitivity Reactions

  • Skin Rashes and Hives: Some individuals report unbearably itchy skin rashes and hives after consuming E627, sometimes called "Ribo Rash". Cases of hives lasting for months have been documented.
  • Swelling: Swelling of the lips, face, and tongue can occur.
  • Asthma Exacerbation: People with asthma may be more susceptible to side effects, including respiratory symptoms like shortness of breath.

Neurological and Gastrointestinal Symptoms

  • Headaches and Migraines: Headaches and severe migraines are commonly reported side effects.
  • Nausea and Dizziness: Experiencing nausea, vomiting, and dizziness is another potential reaction.
  • Gastrointestinal Upset: For some, E627 and other flavor enhancers can cause stomach cramps, diarrhea, and other gastrointestinal disturbances.
  • Fatigue and Insomnia: Some individuals have reported suffering from fatigue, insomnia, and a general feeling of being unwell after consumption.

Who Should Avoid Flavour Enhancer 627?

Certain individuals should be particularly mindful of their intake of Flavour enhancer 627 due to specific health conditions or sensitivities. This includes:

  • People with Gout: Disodium guanylate metabolizes into purines in the body. Since purines increase uric acid levels, this can potentially worsen gout symptoms.
  • Individuals Sensitive to MSG: E627 is often used with MSG to boost flavor. Those with known MSG sensitivity may also react to E627 and the related E631 and E635, as they are often combined.
  • Asthmatics and Hyperactive Individuals: People with asthma or a history of hyperactivity have been advised to avoid it due to potential sensitivity.
  • Infants and Pregnant Women: Food additives like E627 are not permitted in foods for infants under 12 weeks, and caution is advised for pregnant women.

Identifying and Navigating Flavour Enhancers

For those who suspect they are sensitive to flavour enhancers like E627, careful label reading is essential. This can be complicated by manufacturers using various names or broad terms for additives.

Reading Food Labels for E627

E627 might appear on an ingredient list under several names:

  • Disodium Guanylate
  • Disodium 5′-Guanylate
  • E627 (in Europe)
  • INS 627 (an international code)
  • Potentially hidden within "natural flavors" or "yeast extract".

Comparison Table: Flavor Enhancers

Feature Flavour Enhancer 627 (Disodium Guanylate) MSG (Monosodium Glutamate) I+G (Ribonucleotides - E627 + E631)
Function Enhances savory umami flavor Classic savory umami flavor Potent synergy of umami flavor
Effectiveness Strong enhancer, potent on its own Effective, but can be less strong than combined Creates a very powerful umami effect
Source Produced via fermentation (e.g., from starch) Fermentation of starch or sugar Combination of E627 and E631
Primary Concern Sensitivity reactions, gout link Common sensitivity reactions Combined effects, "Ribo Rash"
Usage Processed snacks, sauces, soups Widely used, including restaurants High-flavor processed foods

Conclusion

While regulatory bodies classify Flavour enhancer 627 as safe for general consumption, it is clear that for a sensitive minority, it can trigger uncomfortable and even severe reactions. Symptoms range from headaches and dizziness to gastrointestinal upset and chronic skin rashes. Consumers, particularly those with pre-existing conditions like gout or asthma, or a known sensitivity to related additives like MSG, should be vigilant about checking ingredient labels. Making informed dietary choices by opting for fresh, whole foods and reducing reliance on heavily processed items is the most effective way to mitigate the potential risks associated with this additive. More information on food additives and sensitivities can be found from health organizations like the Mayo Clinic.

Note: If you experience any adverse symptoms after consuming food containing E627, it is advisable to consult a healthcare professional. Self-diagnosis can be misleading, and medical advice is important for managing health concerns.

Frequently Asked Questions

Flavour enhancer 627 is commonly found in instant noodles, processed snacks, soups, sauces, seasonings, and other ready-to-eat meals where an enhanced savory flavor is desired.

While food safety authorities generally consider E627 safe for the majority of the population, a notable minority of sensitive individuals may experience adverse reactions.

For sensitive people, E627 can cause allergic-type symptoms such as skin rashes (including "Ribo Rash"), hives, and swelling of the face or tongue.

People with gout should avoid E627 because it breaks down into purines in the body, which can increase uric acid levels and potentially exacerbate gout symptoms.

No, E627 (Disodium Guanylate) is not the same as MSG (E621), but the two are often used together to create a more powerful umami flavor effect. Individuals with MSG sensitivity may also react to E627.

Yes, E627 may be included in processed foods under less specific terms like "natural flavors" or "yeast extract," making it difficult to identify.

Common symptoms of E627 sensitivity can include headaches, dizziness, nausea, vomiting, skin rashes, gastrointestinal issues, and respiratory problems for asthmatics.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.